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Kabeche Lab @KabecheLab

The Kabeche Lab at Yale University is dedicated to uncovering the mechanisms that drive genome instability.

Joined April 2020
  • Tweets 31
  • Following 62
  • Followers 235
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Kabeche Lab retweeted
Yale West Campus@YaleWestCampus
1 Aug 2024
Congratulations to Lilian Kabeche, faculty member @CancerYale @YaleMBB, who has received @ASCBiology Award for Excellence in Research by an Historically Excluded Person. Read more about Lily's research and mentorship of next gen diverse scientists: bit.ly/Kabeche-award
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Congratulations to all the winners (including our awesome leader, Lily!)
American Society for Cell Biology@ASCBiology
1 Aug 2024
ASCB is proud to announce the 2024 Honorific Awards! Join us in celebrating the outstanding achievements of our members in research, education, and mentoring. Check out the full list of honorees and their contributions to the life sciences here: ascb.org/society-news/ascb-a…
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Chk(2) out our most recent work! We’re excited to share our discovery about a new mechanism that controls mitotic PLK1 activity: biorxiv.org/content/10.1101/…

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation

Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division. PLK1 activity is tightly regulated throughout the cell cycle. Although the...

biorxiv.org
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Although Chk2 and the DNA damage response pathway canonically antagonize mitotic kinases like PLK1 at the G2/M checkpoint, our data shows that this relationship is inverted in mitosis, highlighting how well-characterized interphase signaling pathways can be rewired in mitosis.
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We’re so grateful to everyone who contributed to this project @Yanshen73854711 @CancerYale and for valuable feedback from the community. Let us know what you think!
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Excited to see Elizabeth's presentation at the Cell Cycle Club meeting!
Robertus de Bruin@DeRobertus
28 Feb 2024
PROGRAMME Virtual Cell Cycle Club meeting: Wednesday March 13 3 short talks: Gergely, Mittnacht & @KabecheLab Breakout session talks Keynote: @JanSkotheim Breakout slots still available, deadline this Friday!! To REGISTER or SUMIT abstract @abcam events.abcam.com/event/bfdb7…
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Great paper from the Sheltzer lab!
Jason Sheltzer@JSheltzer
12 Oct 2023
New from my lab: we show that a clinical-stage oncology drug from Eli Lilly is mischaracterized, and its true anti-cancer target is EGFR. We also show how in vitro drug assays can be misleading - cellular genetic methods are needed to determine drug MOAs.
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Congratulations @SusanBaserga!! Well deserved!
Yale Cancer Center
@YaleCancer
9 Oct 2023
Congratulations to Yale Cancer Center members, Dr. Susan Baserga @SusanBaserga and Dr. Emily Wang, on their elections to @theNAMedicine, a prestigious honor! @SmilowCancer @YaleMed @YNHH @YaleMBB @YaleGenetics @YaleRadOnc @SEICHE_Yale
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Our paper is now online! ATR promotes micronuclei rupture and clearance.
Molecular Cell@MolecularCell
2 Oct 2023
Online Now: ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei dlvr.it/Swtqfp
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Great talk by Elizabeth on novel mechanisms of PLK1 regulation at the @YaleMBB retreat!
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Great paper by the Simon Lab! @YaleMBB
Lemmon and Ferguson Labs@LemmonFerguson
20 Sep 2023
Another Yale West Campus Nature paper: nature.com/articles/s41586-0… Congrats to the Simon lab and collaborators.
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Great publication by the Bleichert lab!
Bleichert Lab@BleichertLab
8 Aug 2023
Our latest publication is out now! Check out our paper in @embojournal investigating how ORCA facilitates replication initiation in heterochromatin environments. Congrats to @SahuSumon, Babatunde Ekundayo, and @Ashishk1722 on this team effort! doi.org/10.15252/embj.202311…
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Congratulations Mandar!! 🍾
Yale Cancer Biology Institute@CancerYale
2 Aug 2023
Congratulations to #YCBI faculty member Dr. Mandar Muzumdar @MuzumdarLab, for his promotion to Associate Professor! @YaleWestCampus
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4-year Lab Anniversary! 🎉 Over the past 4 years, we've changed biological paradigms & published some great papers, obtained 5 grants, presented our work on national and international stages, & created unforgettable memories. Proud of our accomplishments! @YaleMBB @CancerYale
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Great job on your STARS end-of-summer presentation, Carla!! @CancerYale @YaleMBB @YaleWestCampus
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Kabeche Lab retweeted
Yale West Campus@YaleWestCampus
17 May 2023
“When we identify all the ways a protein works, we can better predict how drugs targeting that protein will affect patients” – Scientists @KabecheLab discover a multi-tasking protein with potential to protect against disease: bit.ly/protein-progress @CellReports @CancerYale
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Excited to share our latest work uncovering a novel mechanism by which ATR protects the genome in the absence of DNA damage! @YaleMBB @CancerYale cell.com/cell-reports/fullte…

ATR protects centromere identity by promoting DAXX association with PML nuclear bodies

Aberrant changes to centromere composition can cause mitotic defects leading to aneuploidy and cancer. Trier et al. identify a non-canonical role for the DNA damage response kinase, ATR, in promoting...

cell.com
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To all the fans of cell division in the New England area, there is still time to register for the 2023 BAMM meeting! The free one day meeting will be held @Yale on May 6th. Use the link to check it out and register! bamm-meeting.com
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#Celldivision fans: check out the 2023 BAMM meeting!! This awesome one day free conference will host an exciting set of speakers from the New England area! This year it will be hosted at @Yale University! Submit a short abstract by April 1st for an opportunity to give a talk.
Binyam Mogessie ቢንያም ሞገሴ@BinyamMogessie
21 Mar 2023
Check out this year’s Boston Area Mitosis & Meiosis (BAMM!) meeting @KabecheLab (Yale), Dan Needleman (Harvard) and I are organizing. Please spread the word and register for a day of exciting cell division biology on May 6, 2023 at Yale. bamm-meeting.com/
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