Zebrafish, Alzheimer's disease, neural stem cells, regeneration @Columbia @ColumbiaMed | Own views, no endorsements
Joined October 2016
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New paper in Current Biology! Led by Maria Antonietta Tosches lab @Columbia. Happy we could be part of this beautiful work.
Cajal–Retzius cells are not just a mammalian innovation - they trace back to an ancient Tp73⁺ neuron family across vertebrates.
doi.org/10.1016/j.cub.2026.0…
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Kizil Lab retweeted
3 Jul 2025
Last week , Caghan Kizil, Ph.D., from Columbia University Irving Medical Center, presented an engaging seminar on “Fibronectin as a Proximal Mediator of APOE-ε4-induced Blood-Brain Barrier Dysfunction in Alzheimer’s Disease.” See flyer here > buff.ly/s5kCCqc
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2024 was an incredible year for #KizilLab! 🎉
✨ Many publications, 🏆 awards, 💡 innovations & patents! We are proud of our team!
Thanks to collaborators, supporters, and @ColumbiaMed for making it all possible.
Here's to 2025! #ScienceForAll
🔗 kizillab.org
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Kizil Lab retweeted
4 Dec 2024
🔑Highlights:
- Pacemaker-like neurons in the IcNS, generating rhythmic activity autonomously 🧠💓
- A complex diversity of neurotransmitter systems finely tuning heart rhythms 🔬
- Ex-vivo study of intact neural heart networks 🧪
Why it matters: This research challenges the idea that the heart is just a simple relay, positioning the IcNS as a key player in rhythm generation. A leap toward new therapeutic strategies for arrhythmia and heart failure.
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Kizil Lab retweeted
4 Dec 2024
This collaborative effort from teams at @karolinskainst and @Columbia @ColumbiaMed, led by @AmpatzisLab and @KizilLab, showcases the power of teamwork.
Congratulations to all authors, including the first authors Andrea Pedroni and @gaattagca! 🙌 This work wouldn’t have been possible without the generous support of our funding agencies; thank you! 🙏
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Kizil Lab retweeted
4 Dec 2024
🚨 Our new study "Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system" out in @NatureComms! 🌟
We identify the "little brain" of the heart: the intricate intracardiac nervous system (IcNS) of zebrafish! 🐟 Learn more here about how this changes what we know about heart functionality.
nature.com/articles/s41467-0…
🧵
#Cardiology #Zebrafish #Neuroscience #HeartResearch #LittleBrain
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Kizil Lab retweeted
4 Dec 2024
Excited to share @AmpatzisLab and @KizilLab's's new paper on #zebrafish 's intracardiac nervous system (IcNS), highlighting the presence of pacemaker-like neurons that partake in heart rhythm—linking cardiac and neuroscience research. nature.com/articles/s41467-0…
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We are happy to share that our ABCA7 paper published in @CellGenomics 🎉
Thanks to all our collaborators.
30 Aug 2024
We're excited to share our new study on the role of the ABCA7 gene in brain resilience against #Alzheimer’s. Published in @CellGenomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating #neuropeptide Y (NPY), a key molecule for brain communication and repair. Loss of ABCA7 reduces NPY, weakening the brain's defenses against AD.
By combining #zebrafish models, human datasets, and #patient-derived iPSCs, we discovered that ABCA7 variants impact synaptic integrity and brain function. Our study also highlights how Alzheimer mechanisms mechanisms vary across different ethnicities. Understanding ABCA7's role in diverse populations can help develop more targeted and effective treatments. By targeting #ABCA7 and boosting NPY signaling, future therapies could offer better protection against AD, giving us hope for new treatment strategies.
#Neurodegeneration #DiversityInResearch #HealthEquity #BrainHealth
Study Shows How Common Genetic Variants in Black Americans Increase Alzheimer’s Risk cuimc.columbia.edu/news/stud…
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Kizil Lab retweeted
30 Aug 2024
ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling: Cell Genomics cell.com/cell-genomics/fullt…
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It was sad to bid farewell to our Nastasia today but we're excited for her that she's off to start a PhD @Columbia. Nastasia has contributed enormously to all our projects and we were so lucky to have her! We all so proud to see her growth, and can’t wait to call her Dr. Nelson!
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Kizil Lab retweeted
9 Aug 2024
We now have a zebrafish model 🐟 to better dissect the genetics underpinning Fetal Alcohol Spectrum Disorders #FASD - thanks to @CaKizil @gaattagca
@NIAAAnews
preprint here 👇🏼
biorxiv.org/content/10.1101/…
1 Apr 2024
A new project from our lab!
Fascinating #admixture study on this underrepresented South African population and the risk profile for Fetal alcohol spectrum disorders #FASD.
1% to 5% of U.S. first graders have FASD! @NIAAAnews
medrxiv.org/content/10.1101/…
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Kizil Lab retweeted
8 Aug 2024
New from @KizilLab & @gaattagca
8 Aug 2024
Ethanol exposure model in zebrafish causes phenotypic, behavioral and gene expression changes that mimic Fetal Alcohol Spectrum ... biorxiv.org/cgi/content/shor… #biorxiv_pathol
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16 Jul 2024
🚨We're hiring!
We are looking for a Technician B at @KizilLab @ColumbiaMed. If you have lab experience and a passion for research, apply now to join our innovative team in New York City! 🔬 🐟
🔗 opportunities.columbia.edu/j…
#JobAlert #ResearchJobs #NYCJobs #LabTech
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🔬🧠 Proud to be part of this beautiful study led by @DrNErtekinTaner at @MayoClinic on how #vascular pathologies contribute to #Alzheimer's with our #zebrafish 🐟! This study presents key molecular mechanisms that could lead to new treatments.
doi.org/10.1038/s41467-024-4…
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Check out our latest review:
“Multi-target drugs for Alzheimer’s disease”
cell.com/trends/pharmacologi…
15 Jun 2024
Our review is out in @TrendsinPharma.
Multi-target drugs for Alzheimer's disease
"Traditional therapies aimed at single targets have fallen short owing to the complex, multifactorial nature of #Alzheimer's disease that necessitates simultaneous targeting of various #disease mechanisms for #clinical success. Therefore, targeting multiple pathologies at the same time could provide a synergistic #therapeutic effect."
@KizilLab
cell.com/trends/pharmacologi…
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APOE4 carriers with a rare missense mutation in fibronectin were 71 percent less likely to develop #Alzheimersdisease than E4 carriers without the variant. @Columbia ow.ly/9Xqs50RJ0I0
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We're thrilled and proud to see our own @gaattagca win one of the best poster awards at @Columbia this year among the postdocs! 🌟 Very well-deserved recognition. Congratulations, Elanur! Stay tuned for some great stories she'll be publishing soon. 📚 🎉🎉#PostdocSucces
Congratulations to the Poster Winners of the 2024 Postdoctoral Research Symposium on May 3rd!
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cuimc.columbia.edu/news/newl…
We are so excited! 🎉🎉
@Columbia researchers have discovered a genetic variant that reduces the odds of developing #Alzheimer’s disease by up to 70% and may be protecting from the disease.
@ColumbiaMed
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