check out our new preprint! we solved a new nuclease-blocking viral #RNA structure and found some illuminating similarities across diverse viral families. Thread below ⬇️ biorxiv.org/content/10.1101/…
1. Hi #RNA friends, just in time for the holidays I am excited to share the latest pre-print from my group. We solved the structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 & link below – please also check out the full video! #lovevirology
I have two PhD positions available in my group next year! These projects are looking at how disordered regions alter protein dynamics. One is through the Yorkshire BBSRC DTP, advertisement to come, but more information can be found here: whiterose-mechanisticbiology…
My co-first author paper now out in @Nature
SWR1 specifically exchanges H2A/H2B dimers for Htz1/H2B dimers in nucleosomes. Here we show double dimer exchange can be processive, explaining how SWR1 ‘proofreads’ dimer identity in a nucleosome.
nature.com/articles/s41586-0…
Check out the latest work from @lapassmore and @RuedaLab, out now!
It was a great pleasure working with @palconh and @arthur_pol on this amazing story!
Sitting here updating my notebook and thinking how much being a wet lab scientist is like being an emo teen again
"Dear diary, today I ran a gel. It did not go well"
Couldn't be online a lot last week cause of the amazing #RNA2024 meeting, but our latest preprint is out! In case you couldn't catch our poster at the meeting (or if you did and want a second look :P), check out our dissection of the UUCG stem-loop dynamics!
New preprint alert! Using a single-molecule field effect transistor (smFET), we characterize the fast folding and unfolding transitions of a single UUCG RNA stem-loop at a time resolution of tens of microseconds. 1/5 biorxiv.org/content/10.1101/…
I am delighted to share the newest work from the @SternbergLab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.05.08.5…
Check out our new review of the state-of-the-art in the methods and applications of smFRET! Incredibly grateful to @taekjip for leading this effort and thankful for working with the amazing @fei_jingyi, @sciSonja, Nam Ki Lee, Sanghun Yeou, and @Sneha_0027!
nature.com/articles/s43586-0…
Also make sure you have the latest version of the software for your analysis needs. The software is always being updated. You can find the latest updates at the website gonzalezbiophysicslab.github…
Also, please follow and take part in the discussions at github.com/GonzalezBiophysic…
Check out our latest: Using smFRET, we determine an entirely new mechanism for mRNA activation. As part of this work, we assign novel functions for each of the eIF4F components, including a 'hopping' activity of eIF4G and a 'strippase' activity of eIF4A. 🔬biorxiv.org/content/10.1101/…