Assistant Prof @UofT, research group leader @Helmholtz_HIRI. Pathogen systems biology / informatics / functional genomics. Coastal New Hampshirite. Drink Moxie.
Joined October 2016
- Tweets 2,896
- Following 2,091
- Followers 1,001
- Likes 3,569
65 Photos and videos
Pinned Tweet
12 Jun 2025
Very excited about our latest combining advanced cell culture, transposon-insertion sequencing, and statistical modeling to map Shigella virulence determinants in organoid models. Great collaboration w/ @dimartino_ml @SellinLab, out in @NatureGenet
nature.com/articles/s41588-0…
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17 Dec 2025
Our paper on predicting drug resistance in bacteria is out @PLOSBiology. We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. From @YanyingYu w/ @nwheeler443. journals.plos.org/plosbiolog…
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Lars Barquist retweeted
11 Sep 2025
Research Highlight by @madhuramukho: Capturing host-microbe interactions
nature.com/articles/s41592-0…
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Lars Barquist retweeted
30 Jul 2025
Happy to share our lastest story (with @HallezLab, @LBarquist, @CMichaux13) ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence.
Read more here 👉 biorxiv.org/content/10.1101/…
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Lars Barquist retweeted
15 Jul 2025
Could lab-grown mini-organs help scientists research a range of infections? A new study published in @Nature Genetics shows how researchers have mapped how the Shigella bacterium infects the human gut.
Read our interview with study co-author @LBarquist: uoft.me/bI7.
ALT Lars Barquist, Assistant Prof at the Department of Biology at UTM
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18 Jun 2025
RT @NaturePortfolio: A study in @NatureGenet establishes the comprehensive genome-wide map of Shigella genes required to infect human intes…
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Lars Barquist retweeted
12 Jun 2025
Very excited about our latest combining advanced cell culture, transposon-insertion sequencing, and statistical modeling to map Shigella virulence determinants in organoid models. Great collaboration w/ @dimartino_ml @SellinLab, out in @NatureGenet
nature.com/articles/s41588-0…
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Lars Barquist retweeted
13 Jun 2025
Large-scale organoid models, combined with genome-wide mutagenesis screening, reveals virulence factors required for Shigella colonization @dimartino_ml @NatureGenet @SellinLab @LBarquist
nature.com/articles/s41588-0…
nature.com/articles/s41588-0…
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Lars Barquist retweeted
19 Feb 2025
Presenting a new flexible web platform for sharing and integrating microbial omics data, including RNA-seq and transposon-insertion sequencing.
Micromix: web infrastructure for visualizing and remixing microbial ‘omics data doi.org/10.1093/gigascience/…
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Lars Barquist retweeted
18 Feb 2025
New paper, discussing open problems in bacterial phenotype prediction with ML: arxiv.org/abs/2502.07749
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Lars Barquist retweeted
13 Feb 2025
I am happy to tell that our collaborative review article on #PhageTherapy has been just published in Nature Reviews Methods Primers rdcu.be/d9H92
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Lars Barquist retweeted
4 Feb 2025
Interested in collecting, sharing, and interacting with large collections of bacterial functional genomics data (RNA-seq, Tn-seq/TraDIS, etc.)? Check out our new web platform, Micromix, with case studies for Salmonella and Bacteroides! Thread 1/n
academic.oup.com/gigascience…
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Lars Barquist retweeted
10 Feb 2025
🚀 New Paper Alert! 🚀
𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure
Check it out in @NAR_Open:
academic.oup.com/nar/article…
Here’s why you should give it a try 🧵👇
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4 Feb 2025
Interested in collecting, sharing, and interacting with large collections of bacterial functional genomics data (RNA-seq, Tn-seq/TraDIS, etc.)? Check out our new web platform, Micromix, with case studies for Salmonella and Bacteroides! Thread 1/n
academic.oup.com/gigascience…
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4 Feb 2025
We've already applied this together with the @WestermannLab to build a web server for Bacteroides thetaiotaomicron (nature.com/articles/s41564-0…), you can check that out here: micromix.helmholtz-hiri.de/b…
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4 Feb 2025
Anyway, we hope to build this out into a series of community resources -- hope people find it useful and feel free to get in touch if you're interested in using it!
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Lars Barquist retweeted
25 Jan 2025
When you find a key paper, the last thing you want is to miss related studies that could strengthen your literature review.
Connected Papers can help you uncover related research.
You can now save references discovered in @ConnectedPapers directly to Paperpile. Learn more in our blog post 🔽
paperpile.com/blog/connected…
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