@LSchmidheini profile picture
Lukas Schmidheini @LSchmidheini

Student @ ETH Zurich

Joined January 2013
  • Tweets 19
  • Following 230
  • Followers 62
4 Photos and videos
Lukas Schmidheini retweeted
András Tálas
@talasandris
20 May 2025
Our paper describing an RNA-LNP prime editing strategy for treating phenylketonuria was published today in @natBME (1/7) nature.com/articles/s41551-0… @schwanklab @UZH_Science @UZH_en @KispiZuerich @ETH_en

Treatment of a metabolic liver disease in mice with a transient prime editing approach

Nature Biomedical Engineering - A transient in vivo prime editing strategy is developed for the liver by delivering the prime editor as mRNA encapsulated in LNP.

nature.com
2
10
27
2,698
Lukas Schmidheini retweeted
Kim Fabiano Marquart
@marquark
23 Sep 2024
If you're more of a visual learner, this explainer video is for you 🙌
4:34
3
5
303
Lukas Schmidheini retweeted
University of Zurich@UZH_en
23 Sep 2024
TnpB is much smaller than the well-known CRISPR-Cas "gene scissors". The tool for targeted modification of the genome has now been improved to such an extent that it could one day be used to treat a genetic defect that leads to a lifelong high cholesterol level. news.uzh.ch/en/articles/medi… @schwanklab @marquark @UZH_IPT
1
5
29
2,362
Lukas Schmidheini retweeted
Gerald Schwank@schwanklab
23 Sep 2024
Excited to share our latest study! Today in @naturemethods the @schwanklab and @krauthammerlab report in @marquark et al. 'Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs' (1/6) nature.com/articles/s41592-0…

Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs

Nature Methods - This work introduces engineered TnpBmax proteins with enhanced efficiency and an expanded targeting range. By leveraging an extensive dataset on editing efficiencies, it also...

nature.com
5
30
82
13,303
Lukas Schmidheini retweeted
Nicolas Mathis@nicopmat
21 Jun 2024
Our paper exploring the effect of chromatin on prime editing and diverse pegRNA designs was published today! 👨‍💻🧬🎉 rdcu.be/dLu0f pridict.it @UZH_Science @NatureBiotech @schwanklab @krauthammerlab @bvansteensellab 🧵
7
36
148
21,396
Lukas Schmidheini retweeted
Lukas Villiger@lukas_villiger
2 Feb 2024
Impossible to do the field justice on a few pages but we (@jgooten @omarabudayyeh @jsw @JuliaJoung @LukeKoblan) tried our best to give an overview of current CRISPR technologies in @NatRevMCB rdcu.be/dxDD9

6
13
66
19,846
Lukas Schmidheini retweeted
Nicolas Mathis@nicopmat
10 Oct 2023
🚨New preprint🚨Today, we're excited to share our latest study, "Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning" via @biorxivpreprint! @schwanklab @krauthammerlab @bvansteensellab @UZH_Science biorxiv.org/content/10.1101/… 🧵

Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine...

Prime editing is a powerful genome editing technology, but its efficiency varies depending on the pegRNA design and target locus. Existing computational models for predicting prime editing rates are...

biorxiv.org
1
26
57
11,721
Today we @schwanklab report in @nchembio a PACE-evolved, PAM-relaxed, compact Cas9 enzyme. evoCjCas9 supports base- and prime editing, and, owing to its small size, can be delivered on single AAV vector systems. nature.com/articles/s41589-0… @UZH_Science @ETH_en (1/6)

3
16
70
19,192
more replies
I’m very thankful for all the support from our @schwanklab members, including @nicopmat, @marquark, @tanjarothgangl, @KisslingLucas, @BoeckDesiree, @priswang5 and @ChrisChanez89 from the lab of @MartinJinek. Plasmids related to this study are available on @Addgene. (6/6)
1
3
348
And here is the ReadCube link to access the paper🔓: rdcu.be/dmIkc
3
253
Lukas Schmidheini retweeted
Kim Fabiano Marquart
@marquark
26 Jun 2023
🎙️Excited to launch my new podcast #CRISPRli, a deep dive into the revolutionary world of #CRISPR. I'll be hosting interviews with top genome editing experts. Ideal for scientists, students or anyone curious about this cutting-edge tech. #GeneEditing open.spotify.com/show/1NDD79…
4
25
77
6,858
Lukas Schmidheini retweeted
Nicolas Mathis@nicopmat
16 Jan 2023
Excited to see our study "Predicting prime editing efficiency and product purity by deep learning" published in @NatureBiotech today! @schwanklab @krauthammerlab nature.com/articles/s41587-0… 1/14
1
26
106
49,783
New preprint of @schwanklab on bioRxiv. Congrats @PatrikSimmler and collaborators for this nice story!
Patrik Simmler@PatrikSimmler
11 Nov 2020
I am happy to share our preprint about the #splicing factor SF3B1 that contributes to tumor malignancy by facilitating the adaption to hypoxia in solid cancers. SF3B1 interacts with #HIF1α and acts as a transcriptional co-activator. -> Thread (1/4) biorxiv.org/content/10.1101/…
9
Lukas Schmidheini retweeted
Nicolas Mathis@nicopmat
10 Nov 2020
New preprint from the @schwanklab! We present a novel base editor variant (HNHx-ABE) with a shifted editing window and reduced size. Congratulations to @lukas_villiger and everyone involved in this elegant study!💪 biorxiv.org/content/10.1101/…
2
6
Lukas Schmidheini retweeted
Jacob Corn@jcornlab
16 Aug 2019
My lab is hosting a happy hour together with Zenobi-Wong and Schwank labs. The theme is airports. What you see here is a homebrew, working metal detector with alarm that attendees pass through upon exiting the elevator. Welcome to @ETH_en, where even the biologists are techies.
3
26
Load more