T cell friends! CAR T cell aficionados! Here a quiz for you! The TCR have four signalling chains, the CAR uses only one, which one do you think will perform best?

Un autentico honor y un placer volver a Majadahonda. Aquí hice mi tesis doctoral, aquí nació la semilla de la investigación, y ahora volver cierra un emotivo circulo. Gracias a la SICAM por la invitación.

Had a great visit to the Kennedy Institute at Oxford yesterday- thanks @AGerardLab for hosting me!

On Monday 18th Nov, Dr Mahima Swamy joins us to talk about "The multiple roles of intraepithelial T lymphocytes in maintaining intestinal homeostasis". Don't miss it! Oxford Talks: talks.ox.ac.uk/talks/id/c51b…

Vamos, @RafaelNadal!   As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional.   Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I was stepping into your backyard, and you made me work harder than I ever thought I could just to hold my ground. You made me reimagine my game—even going so far as to change the size of my racquet head, hoping for any edge.   I’m not a very superstitious person, but you took it to the next level. Your whole process. All those rituals. Assembling your water bottles like toy soldiers in formation, fixing your hair, adjusting your underwear... All of it with the highest intensity. Secretly, I kind of loved the whole thing. Because it was so unique—it was so you.   And you know what, Rafa, you made me enjoy the game even more.    OK, maybe not at first. After the 2004 Australian Open, I achieved the #1 ranking for the first time. I thought I was on top of the world. And I was—until two months later, when you walked on the court in Miami in your red sleeveless shirt, showing off those biceps, and you beat me convincingly. All that buzz I’d been hearing about you—about this amazing young player from Mallorca, a generational talent, probably going to win a major someday—it wasn’t just hype.   We were both at the start of our journey and it’s one we ended up taking together. Twenty years later, Rafa, I have to say: What an incredible run you’ve had. Including 14 French Opens—historic! You made Spain proud... you made the whole tennis world proud.   I keep thinking about the memories we’ve shared. Promoting the sport together. Playing that match on half-grass, half-clay. Breaking the all-time attendance record by playing in front of more than 50,000 fans in Cape Town, South Africa. Always cracking each other up. Wearing each other out on the court and then, sometimes, almost literally having to hold each other up during trophy ceremonies.   I’m still grateful you invited me to Mallorca to help launch the Rafa Nadal Academy in 2016. Actually, I kind of invited myself. I knew you were too polite to insist on me being there, but I didn’t want to miss it. You have always been a role model for kids around the world, and Mirka and I are so glad that our children have all trained at your academies. They had a blast and learned so much—like thousands of other young players. Although I always worried my kids would come home playing tennis as lefties.   And then there was London—the Laver Cup in 2022. My final match. It meant everything to me that you were there by my side—not as my rival but as my doubles partner. Sharing the court with you that night, and sharing those tears, will forever be one of the most special moments of my career.   Rafa, I know you’re focused on the last stretch of your epic career. We will talk when it’s done. For now, I just want to congratulate your family and team, who all played a massive role in your success. And I want you to know that your old friend is always cheering for you, and will be cheering just as loud for everything you do next.   Rafa that!   Best always, your fan, 
 Roger

Excited to read this paper on the changes in the gut upon ageing

Congratulations Jan! What a year, your are rocking it!

Interesting and important.

Wow, thanks Chenqi for sharing, as always, interesting, insightful and fun to read!

We are happy to publish a perspective @NatRevImmunol, focusing on a charge-based signaling motif BRS. Being widely present in immunoreceptors and other membrane proteins, BRS can regulate many aspects of immune responses. nature.com/articles/s41577-0…

On the way back to @UniFreiburg after the @CIBSS_UniFR review @dfg_public - after being focused on this event for months, time to be a little unfocused or shift the focus to other things.

‼️ Don't miss the next Immunity & Infection #seminar on Monday, November 11, 2024 with Prof. Dr. Christina Zielinski @sfb1160

Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @Nature Huge effort by @Akaron0884 & @BrennethS and the team and collaborators to work this out. Aaron's Tweetorial 👇 nature.com/articles/s41586-0…

Our new work led by our fantastic PhD student Jose (@j__cabezas) showing dramatic reductions in TCR-T cell cross-reactivity without modifying the TCR. Part of this work relied on SPR-based @carterra_bio to measure 163 TCR/pMHC affinities within 24 hours at 37 degrees.

Just over 2 weeks left to apply! Our highly collaborative and interdisciplinary Cluster of Excellence is looking for a new colleague with expertise in #cryoEM #structuralbiology and #signaling #facultypositions #professorship

Come work with me at the @MedUni_Wien - I have a PhD position open which investigates CAR T cell downstream signaling!

#PhDCall 2024: Optimise #CARTcells like a #lego model! 🧬⤵ In one of our PhD projects, you can optimise the signalling pathways of CAR T cells - just like a lego model! Read more and apply now! ➡ bit.ly/3ZK6bOg @ZajcCharlotte

Happy to hear your thoughts about this perspective! Do you think there is still space for further improvements?

Excellent review from the lab about CAR design 😍 Look inside 👀

Do you know how to design innovative CAR T cells? The TCR is an incredible inspiration and has tons to teach us! Check our latest perspective in Nat Rev Immunology: rdcu.be/dXDkG You will find a new exciting way to look at CAR T cells! @CIBSS_UniFR @BUnifr @UniFreiburg

📣 Join us for the yEFIS General Assembly on 🗓️ November 12, 2024, at 5 PM CET via Zoom. 🧑‍💻 ✨ Connect with over 850 young immunologists, meet our task force, and discover upcoming activities and opportunities. 🔗 Register now: tinyurl.com/yEFIS4thGA (limited spots available!)