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Leuschner Lab @LeuschnerLab

Heisenberg Professorship for Immunocardiology @Uniklinik_hd

Joined May 2024
  • Tweets 12
  • Following 161
  • Followers 85
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Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢
Circulation Research@CircRes
8 May 2025
Replying to @CircRes
@CircRes May 9th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.
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EdT@thorplab
17 Apr 2025
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Florian Sicklinger@FloSicklinger
15 Apr 2025
In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion. Check out the full study here: doi.org/10.1161/CIRCRESAHA.1… Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF

High-Throughput Echocardiography-Guided Induction of Myocardial Ischemia/Reperfusion in Mice |...

BACKGROUND: Mouse models of myocardial ischemia with subsequent heart failure are common approaches to examine heart failure pathology and possible treatment strategies. We sought to establish a...

ahajournals.org
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scRNA-Seq profiling of 🫀interstitial cells reveals fibrosis in HFpEF to be distinct from HFrEF including the induction of basement membrane collagens and a protective ⬆️ of ANGPTL4 in murine and human HFpEF | led by @LauraWienecke and @jan_lanzer doi.org/10.1007/s00395-024-0…

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure...

Basic Research in Cardiology - Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exposure to high-fat diet and nitric oxide...

link.springer.com
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Laura Wienecke@LauraWienecke
25 Sep 2024
What do Angptl4 and collagen IV have to do with fibrosis in HFpEF?🫀 Proud to have found some answers!🔬 Thanks to my co-first @jan_lanzer, all authors and our supervisor team for excellent support @LeuschnerLab @JulioSaezRod 👌🏻 link.springer.com/article/10…
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Basic Research in Cardiology@BasicResCardiol
23 Sep 2024
Molecular fibroblast activation patterns in heart failure. link.springer.com/article/10…
Integrated atlas of cardiac fibroblasts from different disease models. UMAP embeddings, showing the integrated fibroblast atlas colored by cell clusters, i.e. the integrated fibroblast states (IFS). Labels indicate possible fibroblast differentiations based on functional characterization.

ALT Integrated atlas of cardiac fibroblasts from different disease models. UMAP embeddings, showing the integrated fibroblast atlas colored by cell clusters, i.e. the integrated fibroblast states (IFS). Labels indicate possible fibroblast differentiations based on functional characterization.
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Christoph Sandmann@chris_sandmann
13 Sep 2024
Check out our paper just published in Circulation ➡️ Translation controls inflammation after myocardial infarction doi.org/10.1161/CIRCULATIONA… This work was a huge collaborative effort over many years. @dzhk_germany @DGK_org @VolkersMirko Key findings paper summary below 🧵⬇️⬇️⬇️

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Bronwyn@BronwynBerkeley
19 Jun 2024
Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction: rdcu.be/dLgU3 Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
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Vesna Todorović@Vesna_Tod
24 May 2024
Couldn't attend the #Immuno-#Cardiology Symposium @FondationLeducq @jacksonlab? No problem-> read the report 'Linking immune modulation to cardiac fibrosis' here 👉 rdcu.be/dIUBP #fibrosis #cardioimmunology
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A shortcut to the infarcted heart Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart. biorxiv.org/content/10.1101/…
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Great support by @CosciaLab @saezlab @LavineLab
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Denis@DenisSchapiro
22 May 2024
I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/shor…

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