Physician-Scientist, investigating innate immunity in cardiovascular disease @uniklinik_hd
Joined August 2020
- Tweets 36
- Following 335
- Followers 184
- Likes 170
Photos and videos
Florian Sicklinger retweeted
Do we study the right biology after myocardial infarction (MI)?
• Surgery in standard mouse model masks MI-specific immune responses
• Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function
tinyurl.com/MImodels
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#SpatialOmics #MyocardialInfarction
#MolecularCartography 100-gene #SeqIF 12-marker #DeepVisualProteomics
4/24/49/96 h postMI🐭
Endocardial vWF mediates Mɸ infiltr
Anti-vWF i.v. reduces Mɸ at endocardial, but not epicardial, core or border, zone, but causes infarct wall thinning worsened cardiac adaptation by 2 wk
Cellpose 2 human-in-a-loop for CardioMyocyte segmentation
Ankrd1 pixel cluster to demarcate stressed/dying CM
Custom analysis pipeline
github.com/SchapiroLabor/mi_…
@flowuenne @FloSicklinger @DenisSchapiro @NatureCVR 2025
nature.com/articles/s44161-0…
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4 Oct 2025
RT @LabWaggoner: von Willebrand factor is upregulated after myocardial infarction and facilitates recruitment of Ccr2 monocytes that worse…
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Florian Sicklinger retweeted
31 Jul 2025
Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab @MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver
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Florian Sicklinger retweeted
10 May 2025
Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at ahajrnls.org/42R7ZGs
@volkersmirko @junedh_amrute @rkramann
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Florian Sicklinger retweeted
8 May 2025
Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢
8 May 2025
@CircRes May 9th Issue is Out! ahajrnls.org/3wPOBJJ
Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.
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15 Apr 2025
In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion.
Check out the full study here: doi.org/10.1161/CIRCRESAHA.1…
Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF
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Florian Sicklinger retweeted
23 Oct 2024
In @Nature we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with @LavineLab @washumedicine, @Amgen , and @ImmunoFibHF nature.com/articles/s41586-0…
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Florian Sicklinger retweeted
13 Sep 2024
Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
doi.org/10.1161/CIRCULATIONA…
This work was a huge collaborative effort over many years.
@dzhk_germany @DGK_org @VolkersMirko
Key findings paper summary below 🧵⬇️⬇️⬇️
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Florian Sicklinger retweeted
3 Sep 2024
Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550 @dzhk_germany @uniklinik_hd ahajournals.org/doi/abs/10.1…
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20 Jun 2024
Thanks to @BronwynBerkeley for highlighting our method in @NatRevCardiol
19 Jun 2024
Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction:
rdcu.be/dLgU3
Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
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Florian Sicklinger retweeted
22 May 2024
A shortcut to the infarcted heart
Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.
biorxiv.org/content/10.1101/…
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Florian Sicklinger retweeted
22 May 2024
I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/shor…
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Florian Sicklinger retweeted
22 Sep 2023
🩵💙🩵💙great symposium - great people - great location!! 🩵💙🩵💙#ImmunoCardiology @jacksonlab #leducq #immunofibHF
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Florian Sicklinger retweeted
21 Sep 2023
Florian Leuschner Kicking off the first US immunocardiology conference at @jacksonlab. @ImmunoFibHF
Very excited about what’s in store the next three days! #CardioTwitter #cardioimmunology
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Florian Sicklinger retweeted
28 Jun 2023
Exciting news for #Immunology and #Cardiology enthusiasts! Join us at #ImmunoCardiology2023 this September 21-23 in beautiful Bar Harbor, Maine to explore the intersection of these fields and discover the latest breakthroughs in #hearthealth research. Register now! #ImmunofibHF🩵
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Florian Sicklinger retweeted
18 May 2023
The #mdcBerlin is very concerned about an ECI request to immediately phase out animal testing. We support the joint @EULIFE_news and @LERUnews
statement: mdc-berlin.de/news/news/join…
Researchers like our group leader @gabrieleschiat1 explain why we can't avoid animal testing yet 👇
ALT Graphic with a quote by Gabriele Schiattarella, the group leader of the "Translational Approaches in Heart Failure and Cardiometabolic Disease" Lab: "Cardiovascular research must rely on animal models. Given the complexity of the cardiovascular system, no acceptable alternatives exist to animal experimentation in order to evaluate the mechanisms of cardiovascular diseases. Only the use of research animal models will provide information that is unique and potentially clinically relevant in the cardiovascular field." Photo: Felix Petermann, Max Delbrück Center
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Florian Sicklinger retweeted
11 May 2023
What’s the difference between fibrosis in HFpEF vs HFrEF❓Check out our new preprint!✅ Thanks to my co-first @jan_lanzer from @saezlab for the fruitful collaboration: biorxiv.org/content/10.1101/…
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