Chromatin & Cancer Biologists at Columbia university
Joined October 2017
- Tweets 353
- Following 367
- Followers 758
- Likes 1,686
12 Photos and videos
May 13
Please spread the word and register. Great event for sharing science and building collaboration for NYC epigenetic labs!
Registration - NYC Chromatin Club - July 21, 2026 - mailchi.mp/nycchromatinclub.…
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2 Dec 2025
Here we go! Excited to share our latest collaborative work with @MichaelMShen and @califano_lab.
We uncovered that NSD2-catalyzed H3K36me2, a histone mark dearest to our lab, is critical for lineage plasticity and resistance to anti-androgen in prostate cancer.
Nature research paper: NSD2 targeting reverses plasticity and drug resistance in prostate cancer
go.nature.com/48oN7Id
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2 Dec 2025
While there is still a lot to learn about the underlying mechanism, these findings suggest the therapeutic potential of combining NSD2 inhibitor with AR inhibitor in treating aggressive prostate tumors. A clinical study is already ongoing: clinicaltrials.gov/study/NCT…
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2 Dec 2025
Further, recent work from Gozani, Mazur, Majewski and Jaremko labs demonstrates therapeutic benefit of NSD2 inhibitor in preclinical models of lung and pancreatic cancers, suggesting a broad role of H3K36me2 in cancer chromatin plasticity: nature.com/articles/s41586-0…
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Lu Lab_Columbia retweeted
12 May 2025
Symposium Registration Deadline Friday! - NYC Chromatin Club - mailchi.mp/cbee4a4e6267/regi…
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Lu Lab_Columbia retweeted
2 May 2025
Registration - NYC Chromatin Club - July 15, 2025 - mailchi.mp/c3d82b17e5c0/regi…
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Lu Lab_Columbia retweeted
23 Apr 2025
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
findaphd.com/phds/project/fu…
Excited to collaborate with @Hannah_K_Long and @bunina_daria (@EdinUni_IGC @MDC_Berlin).
Please share 🙏
#epigenetics
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27 Jan 2025
Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!
27 Jan 2025
In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome.
cell.com/molecular-cell/full…
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15 Nov 2024
Check out this important work - congrats to KJ, Victoria and the team!
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Lu Lab_Columbia retweeted
4 Nov 2024
Please Repost-
Excited to be recruiting @CeiFccc @FoxChaseCancer #epigenetic #faculty to continue building our energetic, interactive, supportive #collegial environment
Our goal- Basic Discovery & help translate to positively impact patients
Apply here-
jobs.sciencecareers.org/job/…
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29 Aug 2024
Here we go - our preprint on the interplay between DNMT3A and polycomb H2AK119Ub mark is published. We believe these findings offer a potential mechanism driving DNA hypermethylation in cancer. Pls see tweetorial for more details. science.org/doi/10.1126/scia…
21 Mar 2024
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.1101/…
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29 Aug 2024
Congrats again to @KristjanGretars @Xagbomson Susan Gloor, Dan Weinberg, @KJArmache @GCloner @epicypher and everyone involved! Thanks to the reviewers and editor @ScienceAdvances for improving our manuscript.
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29 Aug 2024
Lastly, shoutout to two other papers that characterize the interaction between DNMT3A and H2AK119Ub nucleosome.
nature.com/articles/s41467-0… by Jikui Song and Greg Wang groups.
biorxiv.org/content/10.1101/… by @mdrwilson group.
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Lu Lab_Columbia retweeted
30 May 2024
What's new and what's next in cancer epigenetics research? Join us for the 2024 VAI Epigenetics Symposium. Our allstar speaker lineup will highlight the latest advances with a focus on mechanisms and therapeutic applications. Registration closes tomorrow!
vai.org/event/vai-epigenetic…
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Lu Lab_Columbia retweeted
11 Apr 2024
How to pick a problem. Today in @CellCellPress. 1/53
cell.com/cell/fulltext/S0092…
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21 Mar 2024
Please see tweetorial below for the latest from the lab led by @KristjanGretars. In collaboration with @GCloner @KJArmache @Xagbomson, this work reveals molecular details of DNMT3A targeting to polycomb CGIs and its implication for cancer-associated DNA hypermethylation.
21 Mar 2024
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.1101/…
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21 Mar 2024
It also implies that perturbing the interaction between DNMT3A-H2AK119Ub could be a potential strategy to prevent or reverse DNA hypermethylation in cancer.
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21 Mar 2024
Please see tweetorial above for more details! As always, we welcome your feedback and suggestions.
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Lu Lab_Columbia retweeted
1 Feb 2024
Free Hybrid World Class Symposium- Featuring Academic and Pharma/Biotech Leaders!
Register asap. >400 registered and counting.
#Epigenetics #3DGenome #Chromatin
@GAlmouzni @KharasLab @METorresPadilla @ranigeorgelab @LuLaboratory @job_dekker @DaiichiSankyoUS @AstraZeneca @CeiFccc
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