Professor @VAInstitute. Chromatin biochemistry, cancer epigenetics, functional proteomics.
Joined November 2018
- Tweets 261
- Following 255
- Followers 620
- Likes 717
27 Photos and videos
Scott Rothbart retweeted
17 Jul 2025
Big day for the David lab! š Our @MolecularCell paper is out today- huge congrats to first authors @IfeAkano & Jake Hebert for leading this beautiful study uncovering SMARCA3 as a novel H3 E3 ligase that shapes heterochromatin regulation in colorectal cancer š¤©
17 Jul 2025
Online Now: The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer dlvr.it/TLz0Lw
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Scott Rothbart retweeted
27 Jan 2025
A personās lifetime risk for #cancer may begin before they are even born, reports a paradigm-shifting study by Van Andel Institute scientists published in @NatureCancer. @PospisilikJ @Bi0lilla vai.org/cancer-risk-developmā¦
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Scott Rothbart retweeted
Thrilled to share the results @Cancer_Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. cell.com/cancer-cell/fulltexā¦
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Scott Rothbart retweeted
11 Dec 2024
We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!
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Scott Rothbart retweeted
9 Dec 2024
Congratulations to Van Andel Instituteās Dr. Peter Jones, VAI and @HopkinsKimmel's Dr. Stephen Baylin, and @HopkinsMedicine's Dr. Andrew Feinberg, who will receive the Harvey Prize for their groundbreaking work in cancer epigenetics! Read more: vai.org/harvey-prize
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16 Feb 2024
Manuscript acceptance (stay tuned) and a new preprint. Pretty good 24hrs for the lab! biorxiv.org/content/10.1101/ā¦
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5 Dec 2024
This preprint is now published with some key additions guided by an excellent review process @NAR_Open. Also grateful to our collaborators for helping progress this one across the finish line! @suscla1 @qianthefirst @Yael_David__ @zhouwanding and others!
academic.oup.com/nar/advanceā¦
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Scott Rothbart retweeted
3 Dec 2024
Online Now: DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states dlvr.it/TGZ732
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Scott Rothbart retweeted
4 Dec 2024
Congratulations to the authors @RothbartLab, shows the role of UHRF1 in the redistribution of H3K9me3 following DNA hypomethylation, a lingering question in the field and may have implications for the field of aging.
cell.com/molecular-cell/fullā¦
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29 Nov 2024
Two new papers from the lab to end the year! Will be posting about them both at the new place in the coming weeks. @rothbartlab.bsky.social
Come join us - itās great! #SciCommBackAgain
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Scott Rothbart retweeted
13 Nov 2024
Time to move. See you all on Bluesky: @helink.bsky.social
Let's work on getting our respective institutions and our colleagues to move as well. There is an exponential increase in members on Bluesky!!
theguardian.com/media/2024/nā¦
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Scott Rothbart retweeted
8 Oct 2024
If you are interested in a faculty position in the heart of metabolism, at one of strongest and most supportive institutes focused on metabolism, epigenetics, neurodegeneration and more, VAI is recruiting at all levels! vai.wd1.myworkdayjobs.com/enā¦
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Scott Rothbart retweeted
1 Aug 2024
Just 2 postdocs from @DrBrianStrahlās lab (current: me; former: @RothbartLab) with their mentor. Looking forward to joining Scott on the former postdoc/current PI list by the next #BioMethylSRC
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Scott Rothbart retweeted
13 Jun 2024
Registration is still open for this super exciting meeting!
āļøUnbelievable lineup of #epigenetics & #aging speakers
āļøOpportunities for short talks
āļøNew pre-meeting dedicated to trainees w/ extra opportunities for career development & 1:1 with PIs
āļøSpecial awards available!
12 Mar 2024
Excited to be organizing my first international conference w/@petertessarz @TheWebbLab & @Morrison_Lab_SU on #epigenetic & #aging & everything in between!
Amazing speakers (keynotes @BrunetLab @MAF_Dawson @OdedRechavi) & a new opportunity for traineesā¬ļø
events.faseb.org/event/a7662ā¦
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30 May 2024
What's new and what's next in cancer epigenetics research? Join us for the 2024 VAI Epigenetics Symposium. Our allstar speaker lineup will highlight the latest advances with a focus on mechanisms and therapeutic applications. Registration closes tomorrow!
vai.org/event/vai-epigeneticā¦
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29 Apr 2024
Registration closes May 10 for the VAI Epigenomics Workshop. This 3-day, hands-on, problem-based experience will immerse PhD students in the latest epigenomics research and techniques. Please share with anyone who might be interested! vai.org/event/vai-epigenomicā¦
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9 Apr 2024
Holes in the patio umbrella on the terrace ā¦@VAInstituteā© produced hundreds of tiny eclipse shadows for us to enjoy. ā¦@BurtonNickā© was right place right time to catch some on his shirt too!
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Scott Rothbart retweeted
28 Mar 2024
A pair of medications that make malignant cells act as if they have a virus could hold promise for treating #colorectalcancer & other solid tumors, according to a new preclinical study by scientists @RothbartLab.
#ColorectalCancerAwarenessMonth
vai.org/rothbart-crc-study
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Scott Rothbart retweeted
28 Mar 2024
"The unmet potential of DNA methyltransferase inhibition therapy in patients with solid tumors underscores the importance of our findings."
Congrats to @AmericanCancer grantee @RothbartLab for this this exciting study as we come to the end of #ColorectalCancerAwarenessMonth!
28 Mar 2024
New paper from the lab reveals a link between epigenetic therapy-induced viral mimicry and NFAT:AP1 signaling. Rationale for combining DNMT and EZH2 inhibitors in colon cancer. Thankful to ā¦@theNCIā© and ā¦@ACS_Researchā© for supporting our work! science.org/doi/10.1126/sciaā¦
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28 Mar 2024
New paper from the lab reveals a link between epigenetic therapy-induced viral mimicry and NFAT:AP1 signaling. Rationale for combining DNMT and EZH2 inhibitors in colon cancer. Thankful to ā¦@theNCIā© and ā¦@ACS_Researchā© for supporting our work! science.org/doi/10.1126/sciaā¦
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