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Marco Sciacovelli @MSciacovelliLab

Tenure Track Fellow (Group Leader) at @LivUniISMIB. Studying cancer metabolism, mitochondria, metabolite signalling. Views are my own.

Joined October 2023
  • Tweets 451
  • Following 949
  • Followers 336
3 Photos and videos
Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
May 12
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2026… Interesting finding: Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
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Marco Sciacovelli retweeted
Nature Metabolism
@NatMetabolism
Apr 28
RESEARCH | Yao, Shao, Shan, Wu et al. (Zhejiang U) A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling. dlvr.it/TSGY0Y

Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue...

Nature Metabolism - A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling.

nature.com
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Marco Sciacovelli retweeted
Nature Metabolism
@NatMetabolism
Mar 27
Often forgotten but essential: long-chain acyl-CoAs in metabolic control dlvr.it/TRkLZL

Often forgotten but essential: long-chain acyl-CoAs in metabolic control

Nature Metabolism - Although long-chain acyl-CoA esters are essential to virtually every aspect of lipid metabolism, their regulatory and signalling roles remain underappreciated. These molecules...

nature.com
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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
Mar 19
📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2026… Interesting finding: Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis
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Marco Sciacovelli retweeted
Sofia Costa@ASofiaHCosta
Feb 8
Happy Sunday! Here are the most recent issues of bims-metlip, chock-full of new analytical and computational methods for #metabolomics and #lipidomics biomed.news/bims-metlip/2026… biomed.news/bims-metlip/2026… Brought to you in collaboration with @Bims_BiomedNews

ALT Okay Alright GIF
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Marco Sciacovelli retweeted
Nature Metabolism
@NatMetabolism
Feb 2
#NatMetabPicks | In @Nature led by RK Jain, @geochurch & @mvh_lab (@Harvard) This work highlights the complexity of metabolic dependencies in metastatic site selection. nature.com/articles/s41586-0…

Nutrient requirements of organ-specific metastasis in breast cancer

Nature - How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

nature.com
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Marco Sciacovelli retweeted
Cell Press@CellPressNews
Jan 29
An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/6010Aqwbi Douglas Hanahan @CellCellPress
Figure 2 The dimensions of cancer\nCREDIT Hanahan - Cell.

ALT Figure 2 The dimensions of cancer\nCREDIT Hanahan - Cell.

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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
Jan 26
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2026… Interesting finding: Spatiotemporal regulation of energetic charge dictates T cell function @NatureComms
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Marco Sciacovelli retweeted
Jason R. Cantor@JasonRCantor
Jan 16
For nearly a century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @NatMetabolism, led by @thebioKIMist! Leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q 🧵
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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
Jan 12
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2026… Interesting finding: Albumin orchestrates a natural host defence mechanism against mucormycosis
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Marco Sciacovelli retweeted
CRUK Scotland Inst@CRUK_SI
18 Dec 2025
🆕Paper in @NatureGenet from Georgios Kanellos in @owen_sansom's lab: Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation nature.com/articles/s41588-0…

Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

Nature Genetics - Npm1 promotes tumor formation via attenuating the integrated stress response and p53 activation in mouse WNT-driven intestinal and liver tumorigenesis.

nature.com
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Marco Sciacovelli retweeted
Cancer Discovery@CD_AACR
11 Dec 2025
Now online: The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer doi.org/10.1158/2159-8290.CD…
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Marco Sciacovelli retweeted
Molecular Cell@MolecularCell
10 Dec 2025
Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria dlvr.it/TPlKxf
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Marco Sciacovelli retweeted
Nature Metabolism
@NatMetabolism
20 Nov 2025
RESEARCH | F Kaluba, EC Lien et al. (@VAInstitute): Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth. nature.com/articles/s42255-0…

An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in...

Nature Metabolism - Kaluba, Rogers et al. show that in cancer cells that can metabolize ketones, they may reroute them to produce cytosolic acetyl-CoA and support tumour growth.

nature.com
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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
7 Dec 2025
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2025… Interesting finding: Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
5 Dec 2025
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2025… A huge collection inside! Interesting finding: Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
23 Nov 2025
📢Last 2 weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️ biomed.news/bims-imicid/2025… biomed.news/bims-imicid/2025… Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
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Great work from Suzan Ber and Alessandro Esposito regarding the metabolic reprogramming driven by different KRAS mutation in colorectal cancer. Thank you for involving me in this cool project! embopress.org/doi/full/10.10…

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer

EMBO Reports - Mutations in KRAS, particularly at codon 12, are frequent in adenocarcinomas of the colon, lungs and pancreas, driving carcinogenesis by altering cell signalling and reprogramming...

link.springer.com
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Marco Sciacovelli retweeted
Dylan Ryan
@RyanLab_TCD
10 Nov 2025
Last week's #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2025… Interesting finding: Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
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Marco Sciacovelli retweeted
Nature Metabolism
@NatMetabolism
12 Nov 2025
Reawakening cAMP signalling in cancer cachexia go.nature.com/47UQfLF
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