Very excited to announce that the first paper from the lab is now live @NatureComms #mitochondria #immunometabolism This work was led by postdoc @EloiseMLMrqs with many important contributions from all of our co-authors. New insights since the preprint (summarised below): 1) Biphasic IFN-I expression 2) Late phase IFN-I is mediated by mitochondrial nucleic acid signalling incl. cGAS-STING pathway 3) Reduced IL-1 and COX2 is mediated in part by autocrine IFN-I 4) Systemic IFN-I signalling in different tissues, notably the kidney, in vivo Please check it out! nature.com/articles/s41467-0…

Now online! Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans dlvr.it/TT0Jdr

So excited our paper on mitochondrial phosphatidylinositol (PI) is finally out and chosen as an Editor’s Highlight in @NatureComms! PI is a known component of mitochondrial membranes, yet how its levels within mitochondria shape core functions, is unknown. nature.com/articles/s41467-0…

The pro-inflammatory role of microglia is considered a key driver of Alzheimer's disease. Today @NeuroCellPress discovery of an epigenetic regulator of microglial mitochondria in the experimental model that may be amenable as a target for therapy or prevention cell.com/neuron/fulltext/S08…

Mitochondria directly interact with the nuclear pore complex #mitochondria nature.com/articles/s41586-0…

Mitochondria tethered to the nucleus secure its energy supply nature.com/articles/d41586-0…

Cortical prostaglandin D2 contributes to behavioral sensitization and anxiety in peripheral inflammation dlvr.it/TSz1KV

Neutrophil-derived itaconate facilitates tiered pulmonary inflammation via Kdm5b-associated epigenetic remodeling in alveolar macrophages dlvr.it/TSyCNV

PI is a prominent #mitochondrial lipid but little is known about its regulation and function. In work led by @Zak_Bakes and Rachel Guerra, we discovered that Fmp30p is a PI hydrolase that affects IM protein organization and CoQ production. #HHMInews #WashU nature.com/articles/s41467-0…

🧬💥 Beyond gene editing to total destruction! First author Jingkun Zeng & Nobel Laureate Jennifer Doudna (@doudnalab) at @igiberkeley, @GladstoneInst, @UCBerkeley & @UCSF just published a jaw-dropping paper in @Nature — and it rewrites what we thought CRISPR could do. 📄 "Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding" Forget fixing mutations one by one. This CRISPR-Cas12a2 system doesn't edit cancer cells — it SHREDS them. 🔬 🎯 The target? Mutant p53 — the "guardian of the genome" gone rogue in ~40–50% of ALL cancers, and 70–90% of ovarian, pancreatic & non-small cell lung cancers. Previously UNDRUGGABLE. Not anymore. ⚙️ Here's the elegant mechanism: Cas12a2 scans for cancer-specific RNA transcripts. The moment it detects a mutant signal, it activates — then unleashes total chromatin shredding inside that cell, triggering complete cell death. 💀 Healthy cells? Left completely untouched. ✅ 🤯 The precision? The system distinguished cancer from healthy cells differing by just ONE nucleotide. 🔄 And it's fully adaptable — easily reprogrammed to target new mutations as they emerge. "Not only can this approach target the 'undruggable' cancers that we know, we can also easily and quickly adapt this to new mutations." — Jennifer Doudna 📎 nature.com/articles/s41586-0… #CRISPR #CancerResearch #Cas12a2 #Undruggable #Genomics #ScienceBreakthrough @OncoAlert @oncodaily

Nature research paper: Spermine is an endogenous iron chelator that inhibits ferroptosis go.nature.com/3Sjz8yG

The majority of axonal mitochondria in mammalian neurons lack mitochondrial DNA and do not produce ATP biorxiv.org/content/10.1101/…

DNA sensing and regulation of lipid metabolism dlvr.it/TSyHLh #immunology

This pretty much summarises how most labs in Europe have operated the whole time 😅

Heme orchestrates a tissue stress response to proteolytic damage biorxiv.org/content/10.64898…

Excited to share our new paper out today in @NatureMetabolism! "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" *We bridged spatial metabolomics (MALDI-MSI glycomics lipidomics isotopic pulse-chase tracing) directly to experimental biochemistry (genetic knockdown of glycan enzymes glucosamine supplementation in AD models) and real-world public health data (EHR analysis showing glucosamine use linked to faster MCI-to-AD progression and worse survival). **Key takeaway: The AD brain shows conserved hyperglycosylation driven by ramped-up glycan biosynthesis — not just a byproduct, but a causal driver. Reducing it helps cognition; boosting it (e.g., via glucosamine) worsens outcomes. ***We applied cutting-edge spatial tech to functional validation and clinical translation. Full open-access paper: nature.com/articles/s42255-0… Huge thanks to the incredible team, collaborators (incl. Matt Gentry, Stefan Prokop, @ji0ngbi0n , Yi Guo, @lichenbiostat, Ralph Deberardinis & others), and the patients/families who make this work possible.

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/2026… Interesting finding: Mitochondrial OXPHOS restricts SARS-CoV-2 replication #mitochondria

Functional specialization within the mitochondrial network: Are all mitochondria created equal? dlvr.it/TSxTtm

Remarkable study from Irv Weissman and colleagues @StanfordMed showing that macrophage-mediated xenophagocytosis is a key barrier to interspecies chimerism and that blocking it enhances donor engraftment. (1/2)

We present Effero-seq, a novel approach combining #scRNA-seq with lysosomal acidification tracking by using pHrodo - a pH-sensitive fluorescent marker. This method allowed us to track gradual changes in macrophage gene expression driven by efferocytosis of apoptotic cells (ACs).