The first of a series of new #SerialEM tutorial videos is online - Autocontouring of Grid Squares. Let us know what you think and what topics you would like to see covered in the future! vimeo.com/1009837716
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
biorxiv.org/content/10.1101/…
How can memories persist in the brain when their properties and supporting biological substrates change over time and experiences?
Our latest work newly published in @ScienceMagazine proposes that a balance between memory dynamics and persistence is achieved through the divergent recruitment of multiple memory traces established in parallel upon memory encoding.
science.org/doi/10.1126/scie…
Welcome to the Multiverse of Memory! A thread. 1/7
Our c-di-GMP sensor story is finally out in @NatureComms: rdcu.be/dHsEh. Including new data demonstrating cdGreen2 as a convenient tool to study DGC and PDE activity in vitro. Great collaboration with @simon_vanvliet and @MaierLab!
Join our great BioEM lab team to shape how we use state-of-the-art electron microscopy equipment to study macromolecular assemblies and cell architecture.
Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites!
So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret@davwcbb🥰#officially#teamtomo
How do only 2 non-visual arrestin isoforms regulate ~800 GPCRs?
Our research on CCR5 phosphorylation uncovered a key pXpp phosphomotif crucial for robust arrestin2 recruitment, illuminating intricate details of GPCR desensitization. Now in @MolecularCelldoi.org/10.1016/j.molcel.202…
This was a spectacular collaboration with @BJ_Greber, and @simakali1. Initially, we thought we would need months of microscope time. @AdrianKoh8 & @cushing_v got all data and first structures within 2 weeks! To make this happen we designed a fast #SBDD workflow with @AdrianKoh8👇
Interesting to see myself age so much in one click of a slide 😅. Thanks a lot @ribo_rob for dropping by the @biozentrum to share your beautiful mitoribosome research and to tell us about your new company @cryocloud_io. Providing cloud processing for #CryoEM & #TeamTomo!❄️🔬☁️💻
Here we defined the interactions between the novel enzymatic components responsible for the so far unparalleled introduction of a vinyl chloride moiety to a 21-carbon chain during polyketide elongation! Congrats to the team: @MraDll, Max, Roy, Cedric, Groll lab, and @piel_lab!
Congratulations to @Yves80289860 for completing his PhD in our lab @biozentrum 🥳🥳. Yves’ research provided a big leap forward in understanding the architecture of giant biosynthetic assembly lines known as modular polyketide synthases 👉bit.ly/3Lelpnp. 🎉
After 4 incredible years @biozentrum, I successfully defended my PhD. Thanks to fantastic supervisor Stephan Grzesiek, my committee @LabStahlberg and Prof. Kobilka, and all the collaborators! Looking forward to the next career step as a Project Scientist with @GSchertler at PSI.
Meet biochemist @MariaHondele She has long been fascinated by tiny droplets in the cell, also known as membraneless organelles. In the interview, she talks about her research on this phenomenon and gender equality in science. #WomenInScience
👉 ow.ly/OfEb50MPZcS
Please RT - we have two tenure-track group leader openings @FMIscience. What we have to offer? -> outstanding students & postdocs, spectacular facilities, a caring faculty, very generous core funding, and a Swiss quality of life. Contact me by email if you require more info.