Husband. Dad. EP. Extractor. Implanter. Ass Prof 😯 49 post-nominals: anyone have a spare one to even it up? Royal Melbourne Hospital. 🇬🇧 in 🇦🇺. Quite ranty

Joined August 2018
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Need to help #Epeeps patients understand their condition? Over 1000 copies given out so far, now available for Kindle (tried to make it completely free but Amazon wouldn't let me 😞). Hard copy available soon. @drjohnm @narrowQRS amazon.com.au/dp/B0BWVYFRB4/…
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Gareth Wynn retweeted
Z-E-R-O % !!!🫤
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PFA may have taken away Fellows' chances to learn detailed PVI catheter skills but, in return, they're getting to map a lot more atypical flutters...
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Gareth Wynn retweeted
At @JAMA_current today, 2 radiologists publish what should be the consent form for a total body MRI in healthy people Note: "no major medical society recommends whole-body MRI screening in the general population because it is unproven, and the harms likely outweigh the benefits." jamanetwork.com/journals/jam…
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Zero Fluoro-guided ablation for AF substantially reduces radiation exposure without evidence of higher procedural complication, 12-month freedom from atrial arrhythmia recurrence or procedure duration #OpenAccess onlinelibrary.wiley.com/doi/…
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For the love of God #EPeeps journals - please can PFA catheters be described by their trade names rather than theses stupid circular array / penta-spline / lattice tip / variable loop descriptions that are no less bloody specific!!!!!
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Gareth Wynn retweeted
More than 10 years ago Oussama and I started our journey of investigation, trying to the define the optimal first treatment for patients with atrial fibrillation.  Separately we pursed randomised studies in populations with treatment-naive paroxysmal AF.  Five years ago we presented our RCTs in the paroxysmal AF population, which ended up sitting side by side in the same issue of the New England Journal of Medicine.  nejm.org/doi/full/10.1056/NE… nejm.org/doi/full/10.1056/NE… Since then we have been working together to examine the same question of optimal initial therapy, but instead looking at patients with more advanced forms of atrial fibrillation.  Today Oussama presented the results of the AVANT-GUARD study, which definitively demonstrated the value of initial catheter ablation in the treatment naive persistent AF population. Like EARLY-AF, AVAT GUARD used implantable cardiac monitors to evaluate arrhythmia endpoints   Like EARLY-AF - initial catheter ablation reduced recurrences in AVANT GUARD by about 50%, which was about 25% in absolute terms. To put this another way, only 4 patients need to be treated with ablation to prevent a recurrence of arrhythmia.  However, binary recurrence doesn’t tell the whole story. Because we had loop recorders we were able to assess the time spent in AF (or AF burden). In this regard significantly more patients had none or negligible burden after ablation (<0.1%), with significantly more AAD treated patients having a very high burden (>5%). This is important as AF burden is associated with clinical outcomes such as hospitalisation. In terms of risk - the rates of any adverse event or serious adverse event were comparable between randomised arms. Highlighting that persistent AF patients with high CHADS-VASc score are high risk irrespective of treatment provided. This is important as we reflect on treatment options as part of shared decision-making. Congratulations to Oussama for the presentation and leadership, to the co-investigators and study sites for their participation and dedication, and a huge thank you to the Boston Scientific team for their support and commitment to advancing science.  To end, I want to acknowledge and thank Oussama for this shared journey, I’m grateful for our collaboration and friendship, and look forward to what we will do next.
Apr 25
Presented at #HRS2026: In patients with persistent atrial fibrillation, first-line treatment with pulsed field ablation reduced the recurrence of atrial arrhythmias at 12 months as compared with antiarrhythmic drugs. Full AVANT GUARD trial results: nejm.org/doi/full/10.1056/NE… @HRSonline
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New consensus statement on CIED management and extraction heartrhythmjournal.com/artic…
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Gareth Wynn retweeted
Hot off the press 2026 @HRSonline #CIED management guidelines just dropped - and these ones have a real pulse! Honored to contribute and represent @IDSAInfo @bcmhouston @BCMCME heartrhythmjournal.com/artic…
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Very deep septal...
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Errr @JAMACardio... publishing PhysioSync-HF (LBBAP inferior) and HeartSync-LBBB (CSP superior) simultaneously is certainly confusing but I think you are supposed to know the difference between the two studies 😬
In patients with #HeartFailure and #LBBB, conduction system pacing (#CSP) was inferior to biventricular pacing (#BiVP) for a composite of death, heart failure events, and LVEF change at 12 months. ja.ma/3O23Ef2
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FlecaED: safety & efficacy of IV FLEC in selected AF pts with stable CAD EF > 35% in RCT vs Amio #EHRA2026
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Gareth Wynn retweeted
Safety of Catheter Ablation compared with Antiarrhythmic Drugs for Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomised Trials #OpenAccess @MelbourneEPdoc @DrJasonAndrade @drjohnm @epfellow heartrhythmjournal.com/artic…
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Register now for free: talesymposium.com #EPeeps
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"the burden of proof lies with LAAO" 🙏 🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏
All the explanations I’ve heard today for the negative CLOSURE-AF result—some so strained they’re almost impressive. 1) The devices were “outdated” and therefore responsible for excess complications (the usual argument that things only go wrong elsewhere). 2) DAPT was used after LAAO, which is now said to be obsolete because of bleeding concerns compared with DOAC-based strategies (a claim that is often repeated, less often demonstrated). 3) Stroke rates were similar, so the signal is attributed mainly to bleeding and procedural issues—as if that were a minor point. 4) The composite endpoint is criticized for mixing different mechanisms, although if anything it should have favored non-inferiority. 5) The early phase of enrollment is invoked to argue that complications are not representative of current practice (again, complications seem to belong to others). 6) And then there are the usual remarks about loss to follow-up, crossovers, and lack of blinding. What seems to be missed in this accumulation of arguments is straightforward: the burden of proof lies with LAAO, not with the control arm. The issue is the strength of the evidence supporting LAAO, not medical therapy, which remains the reference standard.
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Be suspicious... when something seems too good to be true, it probably is! 😀 1c almost definitely safe in CCS and the over-extended stigma of CAST needs to be banished 😭 this sort of mortality and MACE benefit from controlling AF is a major 🚩 for selection bias
Class Ic Antiarrhythmic Therapy Following PCI in New-Onset Atrial Fibrillation: Safety and Clinical Outcomes from a Nationwide Cohort heartrhythmjournal.com/artic…
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Gareth Wynn retweeted
Spanish Prime Minister Pedro Sánchez on Iran: Today more than ever, it is essential to remember that one can be against a hateful regime, as is the case with the Iranian regime, as is the whole of Spanish society, and at the same time be against an unjustified, dangerous military intervention outside of international law. That one must be against a war initiated without the authorization of the United States Congress or the United Nations Security Council and, as I have said before, one that violates international law. And that there is always room for a negotiated solution, instead of being dragged along by the devastation of arms as the only possible way out. Therefore, I would like once again, as we have done since the beginning, to appeal for immediate de-escalation, for full respect for international law in all the conflicts we are unfortunately suffering, and for the urgency of resuming dialogue as soon as possible. That is where Spain will be, and that is where I believe the whole of the European Union should be.
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Gareth Wynn retweeted
Here we describe a novel approach to vascular conduit creation to enable CIED implantation in a 4-patient series with limited venous access. A useful technique to explore in those with limited vascular access. @Dr_JHAnderson @JACCJournals @MayoClinic jacc.org/doi/10.1016/j.jacep…
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Gareth Wynn retweeted
Outcome of Pentaspline PFA outside PVs 👇 Acute success does not necessarily translate into long-term success.
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