Cognitive Biases in Multimodal Diagnostic Interpretation: I find this fascinating, and I'll confess that I had an LLM help me with this. I hadn't thought of biases in pathology before, but I think this should be required reading for all pathologists. I'll confess that I've been sucked into each one of these biases over time. I particularly wanted to highlight incorporation bias, where you try to use somebody else's results, such as those from radiology or molecular testing, to interpret our own cytology or histopathology results. 👉Anchoring Bias Definition: Overreliance on the first piece of information encountered. Example: A pathologist may be influenced by a radiology report labeling a lesion as "suspicious," leading to an overly aggressive interpretation of borderline cellular atypia. 👉Confirmation Bias Definition: The tendency to interpret findings in a way that confirms preexisting assumptions. Example: A pathologist may favor a malignant interpretation in the presence of a clinical diagnosis suggesting carcinoma, even when features are equivocal. 👉Diagnostic Overshadowing Definition: A dominant clinical context obscures alternative explanations. Example: A known malignancy may bias interpretation of new findings, with benign lesions misclassified as metastases. 👉Incorporation Bias Definition: Integrating the results of one diagnostic modality into the interpretation of another, compromising independent assessment. Example: Pathologic interpretation is skewed by prior knowledge of a positive KRAS mutation, resulting in upstaging of an indeterminate smear. 👉Framing Effect Definition: Diagnostic interpretation shifts based on how the case is presented. Example: Labeling a specimen as “rule out malignancy” may prime the interpreter toward a malignant diagnosis. 👉Premature Closure Definition: Halting diagnostic deliberation after an early conclusion is reached. Example: A diagnosis of low-grade IPMN may lead to under-recognition of subsequent evidence suggesting high-grade atypia. 👉Availability Bias Definition: Overestimation of a diagnosis based on recent or memorable cases. Example: Recently, encountering a rare pancreatic neuroendocrine tumor may lead to overdiagnosis in future ambiguous cases. @smlungpathguy

Great time at #USCAP2025 in Boston! Fantastic talks, inspiring discussions, and catching up with colleagues. Until next time! #Pathology

Pitfalls of p63: Case 3 This is a spiculated mass detected on imaging. Again, p63 was performed, likely because of the fibrous background and the cribriform features, and it showed positivity. What is your diagnosis? @washu_pathology @washupathedu #breastpath #PathTwitter #PathX

Excited to share the news about the upcoming book ! “Authoritarian practices and humanitarian negotiations”. Grateful for the opportunity to contribute a chapter and design the cover.Dive into this insightful read—I invite you all to explore the diverse perspectives #humanitarian

1/ Met Gala outfits as infectious diseases: A (short) thread 🧵.

So proud of you! ❤️

Congratulations! Excited to have you all! 🎉

Hot off the press! Delighted to share the review article by Jason Chang and I @ModernPathology on the ever-vexing problem of multiple lung carcinomas. This affects ~1 in 5 patients with lung cancer, so is exceedingly common. Recent molecular methods are providing major insights into pathology and clinical aspects here. Please check it out! sciencedirect.com/science/ar… @PulmPathSoc @MSKPathology #PulmPath #MolPath @DrNetto @smlungpathguy

It was so nice to finally meet in-person these 3 wonderful path residents 🇻🇪🔬 Cheers to more moments like these! @MichelleGarlin @path_ale_gy @chofiferraro #NYC #pathology

PGY-1 pitfall #1. Thyroid does NOT have a capsule. I had this realization after submitting multiple thyroids entirely, and my attending pointed out the capsule needed to be submitted only for certain cancers. The thyroid is not encapsulated #humbled #rookiemistake #pathTwitter

How do you determine bone marrow cellularity?…it’s a vibe, or is it? Made this diagram today to help my PGY1 brain solidify the “vibes” of hemepath #hemepath #PathTwitter #pathx #pathstudytips @UMichPath

A corpus amylaceous moon rising above prostate gland hills? #PathArt

The frozen section

"Bullying is a means for mediocre scientists to rise to the top. Some star academics reached their position because they are bullies, not in spite of it." - Excellent piece about bullying in academia (and really any other professional environment). nature.com/articles/s41562-0…

Pathology is gonna be even more fun!😃 🎮 #USCAP2023 #IAMUSCAP #pathojet @TheUSCAP

Selfie with future path experts 🤓😝🥰 @YinGuopath @MichelleGarlin @SalehiazarSara @GuannanTiffany #USCAP2023 #IAMUSCAP @TheUSCAP

Columbia Pathology Residents group picture🤗 @CAPaganPath @Baskotacytopath @Ladan_Fazl @SepideBesharati @nyphospital #Residents #Pathresidents #newyork

As Editor in Chief, I am proud to showcase the November issue of AAP dedicated solely to cytopathology with focus on robust clinical, H&E, immunohistochemical and molecular correlations and incorporation of new standardized classification schema. #PathTwitter