Joined May 2020
Photos and videos
MikaelScience retweeted
Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! pubmed.ncbi.nlm.nih.gov/3901…
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MikaelScience retweeted
Out today from the Blanchard lab! An important paper showing that the accuracy of smFRET measurements depends on excitation strength, and how to correct for these issues or bypass them with self-healing dyes. nature.com/articles/s41592-0…
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MikaelScience retweeted
High resolution Molecular dynamics (MD) of mRNA translation on ribosome
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MikaelScience retweeted
Happy to share that Mathew Gagnon and my lab's joint story of translation inhibition by aminoglycoside Amikacin is now published in @NatureComms 🥳🥳🥳. Superhappy for this collaboration. Fast-kinetics biochemistry and structure together make a very powerful tool afterall 😃
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MikaelScience retweeted
Our study shows that ribosomal genes—widely used to infer the origin of species—also hold a record of the optimal growth conditions for a given species, making it easier to infer the optimal environment for uncultured or extinct organisms (1/3): academic.oup.com/nar/article…

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MikaelScience retweeted
check out our Spotlight Article @TrendsGenetics 🔥 hot 🔥 off the press! teamed up with @OlivierDuss (@EMBLHeidelberg) & @RainerNikolay (@MPI_MolGen) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from @TheBlanchardLab open access 👇 authors.elsevier.com/a/1hJjv…

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MikaelScience retweeted
In our new Spotlight in @TrendsGenetics we are discussing the recent @Nature paper from @TheBlanchardLab about eukaryotic mRNA decoding combining smFRET and cryoEM! Was fun to collaborate with & @MatthewKraushar & @RainerNikolay @MPI_MolGen on this! sciencedirect.com/science/ar…

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MikaelScience retweeted
We suffered two problems on our Krios/Arctica instruments related to a pressure gauge called PPal. Here a picture of the faulty PPal from the Arctica. But then...what is a PPal and how it measures pressure? These two questions kept me busy for a while, a thread to follow 👇
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MikaelScience retweeted
Very soon and thanks to one an only @delarosatrevin an integrated solution for CryoEM facility management and on-the-fly processing with Cryolo/ctfffind/Relion ! And free!!! 👇🏽 Look at these gorgeous ribosome from @TheBlanchardLab !
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MikaelScience retweeted
Happy to anounce our paper published today ⁦@Nature⁩ - a tour-de-force in tRNA biology. We developed suppressor tRNAs with high efficieny in correcting PTCs. For a disease protein we crossed a disease threshold of correction. #cftr #uhh nature.com/articles/s41586-0…
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MikaelScience retweeted
Is mRNA decoding in humans structurally and kinetically distinct from bacteria? news-medical.net/news/202304… @Nature @StJudeResearch #mRNA #bacteria #molecularbiology #research #bacteria #microbiology #cells #news
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See also Research Briefing here: nature.com/articles/d41586-0… Congrats @TheBlanchardLab @MikaelScience @ERundlet @KundhavaiS and all authors!

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Now #OA @Nature: combining #cryoEM and #smFRET to examine decoding by human #ribosome, @TheBlanchardLab reveals important differences from bacterial ribosome and mechanisms of action of several translation inhibitors. nature.com/articles/s41586-0…
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MikaelScience retweeted
Human ribosomes decode messenger RNA 10 times slower than bacterial ribosomes—but do so more accurately. Explore how St. Jude scientists made this discovery. bit.ly/3zxa9v8 @TheBlanchardLab @nature #cryoEM
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MikaelScience retweeted
DNA to RNA real-time speed. Gene Transcription at real-time speed. Transcription is the first step in gene expression.

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MikaelScience retweeted
An MRI of what it looks like when you rub your eyes: #biology by D. Gatinel
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