Visibility limits are placed on this account because Covid reinfections are bad for everyone.
Joined August 2021
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If I were a journalist, I’d ask her how she feels about reinfections — both as a parent and as a physician. Zero mitigation in most schools and inadequate masking in healthcare settings. Her perspective matters.
@MarkJCarney
@jossreimer
@TheCurrentCBC
cbc.ca/listen/live-radio/1-6…
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Nick Mack @NickMack@mstdn.social retweeted
Concerning story about #COVID, #LongCOVID and cancer risk. Dovetails with the work we have been been doing with @drmfreire's team showing that persistent SARS-CoV-2 antigen found in the GI tract of pwLC is pro-inflammatory and oncogenic:
biorxiv.org/content/10.64898…
Stay safe 🙏
“When lab mice with dormant breast cancer cells were infected with either influenza or SARS-CoV-2, the animals were significantly more likely to develop aggressive lung tumors.”
“something similar appeared to be going on in the human population.”
ALT Sceeenshot of LA Times headline reading: “What COVID is teaching doctors about the relationship between viruses and cancer”
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Nick Mack @NickMack@mstdn.social retweeted
I guess I shouldn't be surprised that saying most kids have had COVID multiple times is "controversial" since according to this 2024 Ipsos poll, half of Americans believe they'll never get COVID again.
I'd imagine the % who don't want to learn more is even higher.
ALT Screencap of an Ipsos poll: Half now expect to never get COVID again Q: Which of the following statements most applies to you? I expect that I will get COVID-19 at some point in the future, despite trying to stay as safe as possible. (20%) I expect that I will get COVID-19 at some point in the future, so I have gone about my life as normally as I could. (31%) I do not expect to get COVID-19 at some point in the future. (49%) Source: Ipsos Consumer Tracker, fielded September 4-September 5, 2024 among 1,081 U.S. adults. Ipsos | Consumer Tracker W102
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Nick Mack @NickMack@mstdn.social retweeted
COVID vaccines still protect against heart problems, large study finds arstechnica.com/health/2026/…
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Nick Mack @NickMack@mstdn.social retweeted
“When lab mice with dormant breast cancer cells were infected with either influenza or SARS-CoV-2, the animals were significantly more likely to develop aggressive lung tumors.”
“something similar appeared to be going on in the human population.”
ALT Sceeenshot of LA Times headline reading: “What COVID is teaching doctors about the relationship between viruses and cancer”
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Nick Mack @NickMack@mstdn.social retweeted
I see this type of tweet regularly now. My suspicion is that it's emblematic of the fact that many people globally are struggling with the notion that although societal non-pharmaceutical interventions for Covid-19 are long gone, something is still very off.
It's the virus.
Jun 14
COVID-19 might have been 6 years ago, but it affected us deeply. Nobody remained the same. Time feels faster. The energy feels different.People are colder & more detached. Careers paused, some lost their identity. some are still stuck. The world we knew never really returned.
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Nick Mack @NickMack@mstdn.social retweeted
What COVID is teaching doctors about the relationship between viruses and cancer latimes.com/science/story/20…
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Nick Mack @NickMack@mstdn.social retweeted
18h
Social media is bad for kids but Covid is fine 🤡
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Nick Mack @NickMack@mstdn.social retweeted
Yes. The evidence is that current variants have more severity in young people, including children, than older people. Also, it's decades of epidemiology showing children are infected multiple times. We even have a diagram of viral reservoirs since childhood.
Jun 14
Do we have a source for “the kids have all had COVID multiple times?”
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Nick Mack @NickMack@mstdn.social retweeted
You can’t return to something that doesn’t exist and that’s the predicament we live within currently.
Covid is an ongoing pandemic that the masses are ignoring but it isn’t ignoring them.
This is why people are dying younger and getting sick more frequently than pre 2020.
Jun 14
COVID-19 might have been 6 years ago, but it affected us deeply. Nobody remained the same. Time feels faster. The energy feels different.People are colder & more detached. Careers paused, some lost their identity. some are still stuck. The world we knew never really returned.
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Nick Mack @NickMack@mstdn.social retweeted
The long-term cardiovascular risks of SARSCoV2 infection and reinfections
Your heart is under silent, cumulative attack from SARSCoV2, and every reinfection can reload/worsen the damage.
Here a personal recap of 10 important studies from the last 2 years showing exactly how this virus and its reinfections can/may shape (and shorten) your cardiovascular future.
Evidence is clear, long-term, and growing.
Print and show your Cardiologist.
Let’s connect the dots…
1. Immunothrombosis multi-omics study:
3 months after hospitalisation, long COVID patients still have blood biologically “clot-ready” with persistent endothelial activation and prothrombotic signalling.
x.com/HarrySpoelstra/status/…
2. IL-6 & SAA 6-year study:
Higher acute-phase IL-6 and SAA levels independently predict cardiovascular events and death up to 6 years later, the initial inflammatory storm leaves a lasting CV mark.
x.com/HarrySpoelstra/status/…
3. MIS-C long-term outcomes:
Up to 4.5 years later, MIS-C raises cardiovascular disease risk 14× and hypertension 9× in children, with risks still accumulating.
x.com/HarrySpoelstra/status/…
4. Viruses & cardiac disease review:
SARS-CoV-2 stands out for direct cardiomyocyte invasion explosive damage relentless accumulation of risk with every reinfection.
x.com/HarrySpoelstra/status/…
5. Mayo PET long COVID study:
Persistent cerebral hypometabolism in fatigue/PEM patients still detectable up to 2 years post-infection.
x.com/HarrySpoelstra/status/…
6. Reinfection CV outcomes summary:
Reinfections worsen cumulative heart damage, arrhythmias, thrombosis, stroke risk and long COVID cardiovascular symptoms.
x.com/HarrySpoelstra/status/…
7. Youth reinfection & long COVID study:
Reinfection roughly doubles PASC risk, with myocarditis up to 3.6× higher, heart disease ~2× higher and increased thromboembolism.
x.com/HarrySpoelstra/status/…
8. Mild infection reinfection risk:
Even mild cases trigger lasting endothelial damage and prothrombotic state (1.5–2× long-term CV risk), each reinfection compounds the burden.
x.com/HarrySpoelstra/status/…
9 Mitochondrial dysfunction in long COVID:
Persistent mitochondrial dysfunction and suppressed oxidative phosphorylation remain in long COVID, pointing to durable multi-organ impact.
x.com/HarrySpoelstra/status/…
10. Cumulative reinfection impact on future CV health:
Reinfection stacks additional damage on prior endothelial injury and inflammation, increasing lifetime risk of heart failure, arrhythmias, thrombosis and accelerated cardiovascular disease.
x.com/HarrySpoelstra/status/…
11. Extra, my earlier general reminder post on this exact theme: x.com/HarrySpoelstra/status/…
‼️Overall convergence across the studies:
Immunothrombosis, acute inflammation markers, direct invasion, endothelial damage, and mitochondrial issues create lasting CV vulnerability that reinfections can keep reloading. #L0ngC0vid
The pattern is very clear.
Fewer infections = lower lifetime cardiovascular risk.
You only have one heart.
Protect it!
#AvoidSars2 #AvoidReinfections #CleanAir #VaccineUpdated
🚨GENERAL REMINDER: YOU ONLY HAVE ONE HEART, TREAT IT WITH RESPECT!
Reinfections aren't harmless "boosters", they stack the deck against your HEART, turning one hit into compounding long-term cardiovascular risks.
➡️3 important and recent articles (from 2025–2026) providing the strong evidence that SARS-CoV-2 reinfections increase risks of long COVID, including cardiovascular complications like myocarditis, arrhythmias, heart disease, thromboembolism, and related issues( There're more!!):
➡️1. Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study.
Published in The Lancet Infectious Diseases (2026). This large retrospective study of nearly 500,000 youth found reinfection roughly doubles the risk of long COVID/PASC overall (RR 2.08), with elevated risks for myocarditis (up to 3.6×), arrhythmias, heart disease, thromboembolism, chest pain, and other cardiovascular signs/symptoms, even in vaccinated individuals.
thelancet.com/journals/lanin…
➡️2. Long COVID Syndrome Prevalence in 2025 in an Integral Healthcare Consortium in the Metropolitan Area of Barcelona: Persistent and Transient Symptoms.
Published in Vaccines (MDPI, 2025). This real-world study showed long COVID prevalence was 3–10 times higher in people with three or more infections vs. one, alongside a post-pandemic doubling of thrombotic events (cardiovascular-related clots) across populations, linking reinfections to worsened persistent symptoms including cardiovascular sequelae. pmc.ncbi.nlm.nih.gov/article…
➡️3. Cardiovascular damage and comorbidities related to long COVID: pathomechanisms, prevention, and therapy.
Published in Physiological Research (2025). This review explicitly states reinfections can trigger de novo long COVID or exacerbate its severity, contributing to persistent cardiovascular risks like heart failure, dysrhythmias, myocardial infarction, and stroke, building on evidence of cumulative damage from repeat SARS-CoV-2 exposures. pmc.ncbi.nlm.nih.gov/article…
➡️So:
1. Reinfection worsens endothelial dysfunction (already impaired from prior COVID), raising cardiac event risks, especially in those with pre-existing atherosclerosis or CV factors,
2. Repeat infections cumulatively boost long COVID odds, including cardiovascular manifestations (e.g, myocarditis, arrhythmias, heart conditions 3× higher in some cohorts),
3. Studies show 1.35–2× higher long COVID risk after reinfection vs. single infection. One large pediatric analysis found ~2× higher PASC (including heart-related) post-reinfection in Omicron era.
4. Experts note each infection adds damage, accelerating vascular aging, plaque issues, and overall CV burden, even mild cases.
The reminder: Reinfections aren't harmless "boosters"—they stack the deck against your heart, turning one hit into compounding long-term cardiovascular risks. YOU ONLY HAVE ONE HEART, TREAT IT WITH RESPECT!
PLEASE: #AVOIDREINFECTIONS #AVOIDSARS2 #HEARTHEALTH #CLEANAIR
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Nick Mack @NickMack@mstdn.social retweeted
Experts Praise Public For Adapting To Constant Illness Without Asking Follow Up Questions
ALT An expert and a member of the public experiencing constant illness Headline: Experts Praise Public For Adapting To Constant Illness Without Asking Follow Up Questions STory by Giselda Constnace and Scorch Benzington Photo from Unsplash
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Nick Mack @NickMack@mstdn.social retweeted
Jun 13
We now have a trillionaire on earth but no cure for Long Covid.
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Nick Mack @NickMack@mstdn.social retweeted
Covid should’ve radicalized you but now most of you are 4-5 infections in and suffering major brain damage 🫠😷
Never too late to mask again and actually join a revolution of clean air
Jun 12
the first trillionaire in history backing far right governments across multiple continents should tell you everything you need to know about where humanity is heading. If that doesn’t radicalize you idk what will
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New study shows metformin given during acute COVID-19 infection reduced risk of clinician-diagnosed long COVID by 50%
medicalxpress.com/news/2026-…
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Nick Mack @NickMack@mstdn.social retweeted
Jun 12
"Treating COVID as a transient cold while the biology keeps pointing at durable, mechanistic, multi organ dysfunction is a choice - and at population scale, the cost of not preventing infections lands on real bodies."
➡️LC: persistent mitochondrial dysfunction, suppressed oxidative phosphorylation, and immune dysregulation.
Excellent study explanation 🧵👇
Thanks @ZdenekVrozina 👏
Jun 11
A multi-omics paper on long COVID in Frontiers in Immunology deserves more attention than it got. The through-line is uncomfortable - the cellular power supply stays switched off long after the acute phase is over.🧵
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Nick Mack @NickMack@mstdn.social retweeted
Jun 11
Long-Term Outcomes of Multisystem Inflammatory Syndrome in Children up to 4.5 Years After COVID-19
🚨IMPORTANT new study just dropped: MIS-C in kids is NOT a temporary illness!!
🚨It raises cardiovascular disease risk 14×, hypertension 9×, and gut/lung/brain problems for up to 4.5 years later(=LC)
Earlier “kids recover fine” claims are now officially challenged! Study:👇
➡️ A retrospective cohort study from New York’s Montefiore Health System examined 173 children under 21 with MIS-C versus 346 propensity score-matched controls without MIS-C, all following documented COVID-19 infection.
➡️Follow-up extended up to 4.5 years (March 2020–August 2024) using electronic health records, with MIS-C confirmed by ICD-10 code M35.81 plus CDC/WHO criteria.
➡️Results:
1. MIS-C patients faced markedly elevated risks compared to controls:
- Cardiovascular disorders (aHR 13.88, 95% CI 4.69–41.07),
- Hypertension (aHR 8.86),
- Gastrointestinal disorders (aHR 9.48),
- Respiratory disorders (aHR 3.46), and
- Neurological disorders (aHR 2.02),
- Shock and chronic kidney disease (CKD) occurred almost exclusively in the MIS-C group,
2. Kaplan-Meier analysis showed persistent cumulative incidence in the MIS-C cohort ranging from 6.8% (CKD) to 35.2% (respiratory disorders), with risks diverging and accumulating over years rather than resolving,
3. Preexisting hypertension strongly predicted cardiovascular, neurological, respiratory, and gastrointestinal outcomes,
4. Preexisting diabetes increased CKD risk 49-fold,
5. Older age modestly raised risks of shock and CKD.
6. Sensitivity analyses using stricter MIS-C definitions and alternative respiratory coding confirmed the main results.
7. No mention or data on vaccination and/or reinfection impact.
➡️The study directly challenges earlier reports portraying MIS-C as a transient, self-limited condition with minimal long-term sequelae.
‼️So, MIS-C is not a temporary inflammatory storm that children outgrow. It inflicts severe, lasting multisystem damage that multiplies the lifetime risk of serious cardiovascular disease, hypertension, gastrointestinal, respiratory, and neurological disorders by several-fold to more than ten-fold, while introducing rare but devastating conditions like shock and CKD that almost never occur in peers.
‼️Sadly enough risks continue to accumulate years later.
‼️Earlier short-term “excellent recovery” narratives are contradicted by this longer, rigorous evidence.
‼️Affected children now carry a heavy, potentially permanent burden of chronic illness that will require lifelong medical surveillance and coordinated care or face accelerated morbidity and reduced quality of life!
‼️Of course we need further confirmation, but this does fit the ongoing concerns within the LC science community!
😡So much for paediatric minimalizations!
#AvoidSars2 #AvoidReinfections #ProtectChildren
publications.aap.org/pediatr…
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Nick Mack @NickMack@mstdn.social retweeted
Jun 10
“My doctor said Covid is mild, and masking is not necessary”.
Well your doctor is wrong on both counts and you should not base your health, and life on their personal bias.
If they are saying Covid is mild, they are ignoring over 500,000 peer reviewed publications that shows Covid is not mild, and is highly dangerous, and they are pushing their own biased, and dangerously incorrect opinion.
They are wrong.
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Nick Mack @NickMack@mstdn.social retweeted
Jun 10
Remember the public health officials saying that it's a good thing for people to catch covid regularly because that means that they'll stay immune?
What do you think happens after there's an extended period when fewer people catch Covid?
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Nick Mack @NickMack@mstdn.social retweeted
Jun 10
Bad news: many kids under 8 never received the original Wuhan #COVID vaccines. Their immunity was shaped mostly by Omicron infections. New data suggest the "Cicada" variant (BA.3.2.2), now re-emerging in several countries, may be particularly good at evading immune responses.
Our latest preprint is out, where we investigated a profound SARS-CoV-2 epidemiological anomaly: BA.3.2.2 is selectively infecting children. Here, we show that the lack of ancestral-strain immune imprinting is promoting BA.3.2.2 pediatric infections.
1/9
biorxiv.org/content/10.64898…
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