Professor @GeiselMed @Dartmouth @DMS_MicroImmuno; Laboratory of Antifungal Immunity // Director @MCBDartmouth // JV Soccer Coach @hcaneswirl
Joined March 2020
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Excited to share our most recent pre-print on the role of mycoviruses in triggering the antifungal MAVS-dependent interferon response and their role in regulating chronic allergic bronchopulmonary aspergillosis (ABPA) disease severity.
biorxiv.org/content/10.64898…
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ObarLab retweeted
Championship Day! Boys lax heads to Burlington to face #1 Harwood in a 6:00 game at Virtue Field (UVM). Tickets available on GoFan or at the gate. Fan bus departs at 4:15 from HHS. Might want to bring some rain gear... #GoCanes!!!
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May 29
👉 HIF activity prevents proper macrophage maturation
Deleting VHL → stabilizes HIFs → immature AM phenotype
Only removing BOTH HIF-1α HIF-2α fully restores identity
👉 HIF signaling is the dominant driver downstream of VHL
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May 22
#InterferonPower! #InflammasomePower! 💥With @kjena21 &co we show @NatImmunol that our fungal adjuvant #Mannadjuvant, via IL1 & IFNs, prolongs & potentiates protection of #mRNA #vaccines, broadening it to new variants & overcoming antigenic imprinting! 👉 nature.com/articles/s41590-0…
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May 10
#WeekendRead! #InterferonPower! Cook, Green &co show @JCellBiol that macrophage cell #volume controls their inflammatory response & that macrophage #swelling increases IFN induction synergizing with pathogen-associated molecular pathways!
doi.org/10.1083/jcb.20241113…
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🚨 We’re hiring! Assistant Professor in Immunology @ UMN
CFI LMP seek researchers (including but not limited to inflammation, infection, cancer, neuro, systems immunology).
📍 hr.umn.edu/jobs/Find-Job
🧪 Job ID: 373424
Please share!
#Immunology #AcademicJobs#FacultyJobs
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Apr 30
Trained Immunity friends, we are excited to see you in Montreal in the Fall ! Register w the early bird rate 🫶
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Apr 29
Latest data from the lab out now in mBio. We show that the antibiotic vancomycin directly impairs antifungal function of macrophages via mitochondrial dysfunction. Lots of lovely imaging in this one from @EbRyhmer ! Check it out here:
journals.asm.org/doi/10.1128…
#antibiotics #fungi
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🚨Our newest preprint on the role of iron overload in intiating Influenza-Associated Pulmonary Aspergillosis (IAPA) that was led by recent @MCBDartmouth graduate Dr. Madeleine Grau! biorxiv.org/content/10.64898…
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A new study from the Dang Lab at the Ragon Institute, published in the Journal of Experimental Medicine, has found that the body's immune system inadvertently protects a dangerous fungus from being destroyed.
Read more: ragoninstitute.org/2026/04/d…
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🎉🍾 Congratulations to the newly minted Dr. Madeleine Grau, an @MCBDartmouth PhD student, who successful defended her thesis on the role of iron in the initiation of influenza-associated pulmonary aspergillosis (IAPA).
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Apr 14
🗓Full list of invited speakers for 2027 GRC Immunology of Fungal Infections is now online!
🍄Check out the fantastic line-up and get your application in early - this meeting is typically oversubscribed! Lots of opportunities for talks from the abstracts
grc.org/immunology-of-fungal…
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Fungal diseases are notoriously difficult to treat because these often occur in the setting of impaired immunity. Improving outcomes is likely to require developing immunotherapies. The first conference devoted to this topic will occur this summer.
aegeanconferences.org/confer…
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Jennifer Hunt Named Dean of Geisel School of Medicine home.dartmouth.edu/news/2026…
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Mar 31
How outcomes in relapsed/refractory multiple myeloma changed, from 1986 to 2026
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Mar 31
In the second installment of the short series around fungal infections, Jatin Vyas MD, PhD, discusses the increase in Candida auris including its unique clades and past challenges in diagnosing this difficult-to-treat infection. @jmvyasmdphd
contagionlive.com/view/under…
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Mar 28
Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment
doi.org/10.3390/jof12030229
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Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Pr... sciencedirect.com/science/ar…
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Role for NF-κB in #herpes #encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity. From from Manja Idorn, Søren R. Paludan and colleagues: hubs.la/Q046VYWH0
📘 In our #InnateImmunity collection: hubs.la/Q046V_rv0
#KSInnateImmune26
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ObarLab retweeted
Interested in immunometabolism of macrophages and metabolic crosstalk in the lung?
Read my review just published in @MucosalImmunol:
doi.org/10.1016/j.mucimm.202…
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