Physician-Scientist @OSUCCC_James in #GU #brainmet #CodetoClinic #AIinMedicine #spatialsinglecell | alumni @MDAndersonNews | #cancerfreeworld
Joined August 2022
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Excited to share our upcoming presentations at #ASCO2026 from the @HasanovLab @OhioStatePIIO and collaborators.
This year, our team will present 12 studies spanning:
hasanov-lab.github.io/public…
🤖 AI/ML precision oncology
🧠 RCC brain metastasis biology
🧫 Spatial & single-cell transcriptomics
🌎 Real-world outcomes research with ML models
💻 In silico clinical trial modeling
These projects reflect our 💻 #CodetoClinic 👩⚕️👨⚕️translational framework, integrating computational oncology, multi-omics, and clinical research to advance precision cancer care.
Grateful to our incredible trainees, collaborators, patients, and mentors who made this work possible. hasanov-lab.github.io/team/
@OSUCCC_James @ASCOPost @ASCO @KidneyCancer @kidneycan @urotoday @OncoAlert @oncodaily @OncLive
#KidneyCancer #BrainMetastases #PrecisionOncology #AIinOncology #SpatialBiology #SingleCell #TranslationalResearch
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Proud to see our PhD student, @MostafaIHA, present his work on the single-cell and spatial landscape of RCC brain metastases @OSUCCC_James @OhioStatePIIO @Pelotonia.
Using single-nucleus RNA-seq, spatial transcriptomics, and computational biology, his research explores mechanisms of immune dysfunction and therapeutic resistance in CNS metastases.
Excited to see this work advance our understanding of brain metastasis biology and precision oncology.
#KidneyCancer #BrainMetastases #SingleCell #SpatialTranscriptomics #PrecisionOncology #HasanovLab #OSUCCC #CodeToClinic
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Excited to share our #ASCO26 presentation from the @OhioStatePIIO @HasanovLab Biomedical Informatics PhD Student #PengLi and collaborators!
Machine learning-based transcriptomic signatures predict treatment outcomes across targeted therapy and immunotherapy regimens in renal cell carcinoma
📽️hasanov-lab.github.io/galler…
📜asco.org/abstracts-presentat…
Congratulations to #PengLi and the entire @OhioStateMed @OSUCCC_James #Buckeye team: @OSUWexMed @OhioStateMedOnc @OSU_Urology #OSUPathology @eric_facs @FuatBicer #AmirMortazavi @KimrynRathmell @ZuhairMajeed @semihaxozgul
#KidneyCancer #RenalCellCarcinoma #AIinMedicine #MachineLearning #PrecisionOncology #CancerResearch #ASCO #Oncology #TranslationalResearch #CodeToClinic
@OSUCCC_James @ASCO @ASCOTECAG @KidneyCancer @OncoAlert @oncodaily @OncLive @urotoday
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Machine learning-based transcriptomic signatures predict treatment outcomes across targeted therapy and immunotherapy regimens in renal cell carcinoma key findings:
🔹RNA-based signatures outperformed IMDC risk groups for PFS and OS stratification
🔹Treatment-specific transcriptomic models predicted binary outcome disease control vs progression
🔹Molecular signatures provided prognostic information beyond standard clinical risk models
🔹Supports development of precision oncology tools to personalize RCC treatment selection
📜asco.org/abstracts-presentat…
📽️hasanov-lab.github.io/galler…
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Excited to share our #ASCO2026 poster presentation by our postdoc alumni @BetulGokYavuz1
@UChicago 🌟 physician👩⚕️👩🔬scientist Heme/Onc fellow. Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases
📜biorxiv.org/content/10.64898…
📽️ hasanov-lab.github.io/galler…
This study could not have been possible without multi-institutional collaboration and support from @UTMDAnderson @EJonasch @WinshipAtEmory @bilenma @Hacettepe1967 @hanalioglu @HKUniversity #DavidJHShih, funding and resources @KidneyCancer, @OSUCCC_James @OhioState
@OSUPIIO, @HasanovLab bioinformatics team #PengLi @joseovandor @AleLaFerlita90
#KidneyCancer #RCC #BrainMetastases #PrecisionOncology #CancerGenomics #MachineLearning @ASCOTECAG @OSUCCC_James
@ASCOPost @ASCO @KidneyCancer @kidneycan @urotoday @OncoAlert @oncodaily @OncLive
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Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases @BetulGokYavuz1 @ASCO #ASCO26
Key findings:
🧠RCC brain metastases harbor distinct copy-number alterations (CNAs) compared with primary tumors.
🧬Recurrent alterations involving 8p loss, 8q gain, and 9p21.3 deletionwere enriched in brain metastases across all cancers.
📈These CNA patterns were associated with worse survival and may contribute to brain metastatic progression.
🤖Using genomic features, we developed a machine learning model that identified patients at increased risk of mortality/brain metastasis.
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Congratulations to our star Heme/Onc fellow, @ConquerCancerFd #ASCOMeritAwardee @ShriyaDeshmukh3, presenting at #ASCO26, the spatial transcriptomic profiling of the tumor microenvironment in metastatic RCC treated with sunitinib.
If you missed the presentation: hasanov-lab.github.io/galler…
We are grateful to our collaborators at @UTMDAnderson, @EJonasch, for leading this IIT and @KidneyCancer, @sitcancer, @OhioStatePIIO for funding correlative studies, @HasanovLab bioinformaticians @MostafaIHA @joseovandor leading analysis.
#ASCO26 #SpatialTranscriptomics #TumorMicroenvironment #PrecisionOncology #MachineLearning #CodeToClinic
@ASCOTECAG @OhioState @OhioStateMedOnc @OSUCCC_James @ASCO @Pelotonia
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Key findings of @ShriyaDeshmukh3 presentation at #ASCO26, the spatial transcriptomic profiling of the tumor microenvironment in metastatic RCC treated with sunitinib:
🔹Sunitinib resistance is associated with a profoundly immunosuppressive TME
🔹Enrichment of myeloid suppressive programs (SPP1 macrophages)and T-cell exhaustion
🔹Increased angiogenesis, extracellular matrix remodeling, and hypoxia-related pathways
🔹Adaptive metabolic reprogramming emerges in resistant tumors
🔹Machine learning-derived spatial signatures predicted survival in an independent external cohort
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Elshad Hasanov, MD, PhD retweeted
Feb 19
🚨🚨Multiple Brain Mets Randomized Trial🚨
· Significantly less symptom burden with SRS compared to HA-WBRT
· Better ADL, cognition & KPS after SRS
· SRS Standard of Care 5-20 brain mets
jamanetwork.com/journals/jam…
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Elshad Hasanov, MD, PhD retweeted
Jan 28
The only available data so far would support the ICI rechallege after >1y of previous ICI @ESMO_Open @BrigidaMaiorano sciencedirect.com/science/ar…
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Elshad Hasanov, MD, PhD retweeted
Can we stop excluding brain Mets from clinical trials. These patients need therapy. DART showed that brain Mets did not compromise safety or activity.
pubmed.ncbi.nlm.nih.gov/4137…
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Elshad Hasanov, MD, PhD retweeted
This interdisciplinary consensus effort sought to standardize practical management strategies of single & multiple brain mets in patients with #RenalCellCarcinoma. Authors present a framework to guide treatment decisions for patients. #AUC3
acsjournals.onlinelibrary.wi…
@OncoAlert
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Elshad Hasanov, MD, PhD retweeted
Jan 22
Mapping heterogeneity in the tumor microenvironment of #RenalCellCarcinoma through single-cell omics. #AuthorCommentary on UroToday, Single-cell and spatial technologies are uncovering profound heterogeneity in the #RCC tumor microenvironment—reshaping how we understand CD8⁺ T-cell exhaustion, myeloid diversity, and cancer-associated fibroblasts. These high-resolution insights are paving the way for better biomarkers and more precise, personalized immunotherapy in RCC. #ReadNow > bit.ly/4qYzI0Q @CellPressNews #TrendsinCancer @BetulGokYavuz1 @nkhanmam @ZuhairMajeed @mostafa96721868 @bilenma @eric_facs @HasanovLab
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Elshad Hasanov, MD, PhD retweeted
19 Dec 2025
As 2025 comes to a close, @David_Cohn_MD, @DrRPollock and I thought we’d take a moment to celebrate stories this year that show why @OSUCCC_James is such a powerhouse against cancer.
Here is a thread of 25 inspiring cancer stories in '25:
🧵
ALT Pelotonia riders showing the power of community to support cancer research in the Pelotonia Ride Weekend fundraising event. The image shows a street full of people riding bikes in the direction of the camera, with onlookers viewing from either side of the street.
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Elshad Hasanov, MD, PhD retweeted
Happening now! The 7th Annual #PIIO Symposium Poster Session at Marriott OSU (3100 Olentangy River Rd, Cbus, OH). 🚀 Much more to come with the reception & Director's Address by Dr. @Zihai Li! @OSUCCC_James @Pelotonia #Immuno_Oncology
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3 Dec 2025
A perfect holiday-season read with hot chocolate & cookies ☕️🍪❄️ @trendscancer
“Mapping Heterogeneity in the Tumor Microenvironment of Renal Cell Carcinoma Through Single-Cell Omics” Led by our rising star physician-scientist @BetulGokYavuz1 ✨
Free link: authors.elsevier.com/a/1mCdH…
Grateful for the @trendscancer editorial support, excellent reviewers, and our passionate team & collaborators @OhioStatePIIO @OSUCCC_James @OSUWexMed @KidneyCancer @kidneycan @IKCCorg 🙌
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Elshad Hasanov, MD, PhD retweeted
29 Oct 2025
Kidney Cancer Highlights from ESMO 2025!
@IKCCorg @myESMO #ESMO25 @OncoAlert @ONCOassist
ikcc.org/summary-of-kidney-c…
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Elshad Hasanov, MD, PhD retweeted
28 Oct 2025
🚨 Breaking RCC update from Merck (Oct 28, 2025)
Two back-to-back positive Phase 3 trials for belzutifan (WELIREG®) 👇
1️⃣ LITESPARK-022 – Adjuvant setting
📍 Pembrolizumab Belzutifan vs Pembrolizumab alone
✅ Significant DFS improvement in resected clear-cell RCC after nephrectomy
🧩 1st combo ever to beat ICI monotherapy in adjuvant RCC
OS pending
2️⃣ LITESPARK-011 – Post-IO metastatic setting
📍 Belzutifan Lenvatinib vs Cabozantinib
✅ PFS benefit & higher ORR in patients who progressed after PD-1/L1 therapy
⚠️ OS trend but not yet significant
@OncoAlert
@MedwatchKate
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Elshad Hasanov, MD, PhD retweeted
25 Oct 2025
Thank you to @OSUCCC_James brilient Urooncologist Dr. @eric_facs for arrenging this outstanding @KidneyCancer local meeting and let us to spend time with @Brutus_Buckeye as well and sharing our expertise.
@ChristianRolfo @HasanovLab @KimrynRathmell @OSU_Urology @OhioStateMedOnc
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