OpenCell is a collaborative proteome-scale project to measure human protein localizations and interactions led by the @LeonettiManuel lab @czbiohub
Joined March 2021
- Tweets 16
- Following 3
- Followers 191
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Pinned Tweet
11 Mar 2022
Our paper is now out in @ScienceMagazine! We endogenously tagged 1,310 human proteins and systematically measured their localization and interactions. Check out opencell.czbiohub.org to explore our images and interaction networks!
science.org/doi/10.1126/scie…
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OpenCellCZB retweeted
18 Mar 2022
One of the super useful features of the opencell.czbiohub.org website is that you can look up the cellular copy numbers and concentrations of your favorite proteins - check it out!
(even for proteins that aren't among our targets or their interactors)
11 Mar 2022
Our paper is out today in @ScienceMagazine, I’m stoked @OpenCellCZB !
Check out opencell.czbiohub.org: CRISPR tagging 3D live imaging IP mass spec to map the human proteome.
science.org/doi/10.1126/scie…
👇 tweetorial from our 2021 pre-print.
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Check our perspective on the @OpenCellCZB
awesome work from @LeonettiManuel
"Modules" help interpret biological systems. However, we see in these new data that connectors far outweigh modules in PPI networks! What does that mean? We discuss it: science.org/doi/10.1126/scie…
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11 Mar 2022
Our paper is now out in @ScienceMagazine! We endogenously tagged 1,310 human proteins and systematically measured their localization and interactions. Check out opencell.czbiohub.org to explore our images and interaction networks!
science.org/doi/10.1126/scie…
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11 Mar 2022
All of our data is freely available to explore and download at opencell.czbiohub.org/downlo…. Special thanks to the AWS Open Data program for hosting our collection of 6,000 raw 3D microscopy images: czb-opencell.s3.amazonaws.co…
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11 Mar 2022
This is just the beginning! We are continuing to tag new proteins and we are working on a way to distribute our existing library of cell lines. Stay tuned for new releases of our web portal and datasets!
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OpenCellCZB retweeted
11 Mar 2022
Our paper is out today in @ScienceMagazine, I’m stoked @OpenCellCZB !
Check out opencell.czbiohub.org: CRISPR tagging 3D live imaging IP mass spec to map the human proteome.
science.org/doi/10.1126/scie…
👇 tweetorial from our 2021 pre-print.
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OpenCellCZB retweeted
10 Mar 2022
Published today in Science, a team from CZ Biohub and @MPI_Biochem combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. 🧵 science.org/doi/10.1126/scie…
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OpenCellCZB retweeted
10 Mar 2022
.#OpenCell from @czbiohub -- results from which are published in @ScienceMagazine today -- is mapping cells one protein at a time, paving a new way to visualize cellular architecture. science.org/doi/full/10.1126…. Video: youtube.com/watch?v=6j4fpV-q…
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9 Jul 2021
Excited to see this update! Cytoself enabled us to quantitatively compare our IP/MS interaction data with
our microscopy images (spoiler alert: we showed that if proteins in our library share similar localization patterns, they are more likely than not to directly interact!)
9 Jul 2021
We have an updated preprint of cytoself, our deep-learning method for profiling protein localization with
self-supervised learning!
Fantastic collaboration with @kchev, @LeonettiManuel and @loicaroyer. (1/8)
biorxiv.org/content/10.1101/…
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OpenCellCZB retweeted
31 Mar 2021
Cellular life is amazingly complex. To find cures for diseases, we must understand the molecular details of how cells and their proteins operate.
Visit our new OpenCell website and interactively explore the localization and interactions of human proteins:opencell.czbiohub.org
30 Mar 2021
Endogenous tagging 3D live-cell imaging mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
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30 Mar 2021
Our first release is live! 🚀
A collaborative effort led by @LeonettiManuel with @labs_mann and @loicaroyer and many others at @czbiohub to build an open-source map of the human proteome.
Check it out and let us know what you think!
opencell.czbiohub.org
30 Mar 2021
Endogenous tagging 3D live-cell imaging mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
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OpenCellCZB retweeted
30 Mar 2021
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization biorxiv.org/cgi/content/shor… #bioRxiv
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OpenCellCZB retweeted
30 Mar 2021
Self-Supervised Deep-Learning Encodes High-Resolution Features of Protein Subcellular Localization biorxiv.org/cgi/content/shor… #bioRxiv
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30 Mar 2021
Our first release is live! 🚀
A collaborative effort led by @LeonettiManuel with @labs_mann and @loicaroyer and many others at @czbiohub to build an open-source map of the human proteome.
Check it out and let us know what you think!
opencell.czbiohub.org
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