Postdoc @INSERM, IAME, Paris, France. Working on tolerance and persistance of E. coli UTI #Membrane #Envelope #Antibiotics #Microscopy 🦠
Joined October 2019
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4 Apr 2024
Finally, it's out!!! Super happy to see this work published. Thank you, everyone, for participating in this work.😊If you're curious about the effect of anti-FASII in S. aureus, please check it out!🦠 sciencedirect.com/science/ar…
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Jun 11
Happy to share this publication, which I had the opportunity to contribute to alongside excellent colleagues. 😊 journals.asm.org/doi/10.1128…
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Jun 4
News on the control of metabolism in Bacillus subtilis:
sciencedirect.com/science/ar…
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I'm super happy to share that one part of my PhD research has been published in PLOS Genetics! « FabF and FadM cooperate to recycle fatty acids and rescue ΔplsX lethality in Staphylococcus aureus. » 🥰
Many thanks to all collaborators.
journals.plos.org/plosgeneti…
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May 15
One of the best-known adaptation strategies employed by bacteria is the stringent response, mediated by (p)ppGpp. In #MMBRJournal: a comprehensive update on (p)ppGpp research since 2008, with special paid to the most recent discoveries. Read now: asm.social/2Wt
ALT Regulation of SpoT activity. SpoT activity can be regulated by stimulation of its synthesis or hydrolysis activities. (p)ppGpp synthesis (green) is stimulated by: ACP (acyl carrier protein) during fatty acid deficiency; YtfK during phosphate and fatty acid starvation; and YmgB (conditions unknown). Activation of (p)ppGpp hydrolysis (red) is a consequence of SpoT’s interaction with ObgE (CgtA) during normal growth conditions and Rsd (Regulator of Sigma D) during carbon source downshift.
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We have a PhD position in Leiden within our #ERCSyG @MicroClockERC project to dissect circadian clocks in bacterial biofilms
We are looking for candidates with optogenetics/single cell microscopy/image analysis background
Application deadline 12 June
👉 edu.nl/cqra3
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We poked E. coli while it was “taking a nap” and… turns out it’s REALLY good at hitting snooze and bouncing back 😴➡️⚡ #CeitecMasarykUniversity #Ribosome #RNA #CryoEM
Our new paper in Nat. Commun. dives into how bacteria recover from growth arrest.
nature.com/articles/s41467-0…
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S. copri keeps pace with modern lifestyles
Subset of Segatella copri strains have acquired an additional oxygen regulator via horizontal gene transfer, which confers increased oxygen tolerance. These strains are more prevalent in industrialized countries
cell.com/cell-host-microbe/f…
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May 5
New research in #IAIJournal suggests that intestinal motility shapes spatiotemporal patterns of enterohemorrhagic E. coli colonization and virulence gene expression in the host gut. Learn more: asm.social/2VI
ALT Gut motility supports spatially restricted activation of EHEC virulence genes in wild-type zebrafish larvae.
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Bacteria have amazing respiratory flexibility to tailor their antibiotic tolerance, but its activation is constrained. @stutiisrivastav and @KarvannanL from @TIFR_Bio @TIFRScience produce an intersting interplay between ETS and aminoglycoside tolerance: biorxiv.org/content/10.64898….
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Researchers uncover the role of nucleotide metabolism in #antibiotic #tolerance and targeting nucleotide synthesis synergises antibiotic killing of Vibrio cholera
nature.com/articles/s44259-0…
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Interspecies competition promotes antibiotic resistance with diminishing returns dlvr.it/TRyJFZ
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For readers interested in lipid nanoparticles for oligonucleotide delivery, here's an article covering 60 years of progress in the field
rdcu.be/fb9xD
nature.com/articles/s41573-0…
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Volland et al. discovered a type of bacteria which grows to around a centimeter in length! They explore its remarkable biological adaptations as well. A very interesting read! science.org/doi/10.1126/scie…
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The fatty acid synthesis pathway is a checkpoint for lipoteichoic acid synthesis in Staphylococcus aureus biorxiv.org/content/10.64898… #biorxiv_micrbio
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Bacterial extracellular vesicles as recyclable nutrient reservoirs | Nature Communications nature.com/articles/s41467-0…
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Apr 3
7 books to fall in love with biology:
1) The Lives of a Cell by Lewis Thomas
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UPEC subverts neutrophils
Uropathogenic E coli regulatory system DanRI is induced by nucleosomes present in NETs. DanRI regulates broad cellular responses and dampens neutrophil responses by attenuating reactive oxygen species production & NET formation
cell.com/cell-host-microbe/a…
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Bacterial 2′,3′-cGAMP triggers membrane disruption to restrict phage
In response to phage, CdnB enzymes in CBASS systems synthesize 2′,3′-cGAMP, which activates Cap14 that induces filament formation & premature cell lysis
cell.com/cell-host-microbe/f…
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Researchers engineered nonreplicating “SimCells” that selectively bind to and inject toxic proteins into multidrug-resistant bacteria. SimCells can also convert aspirin into hydrogen peroxide, killing more than 97% of target bacteria. In PNAS: ow.ly/4esP50YySHp
ALT Design of the SimCell and mini-SimCell platform for treating bacterial antimicrobial resistance. Surface-displayed nanobodies are engineered to the outer membrane of SimCell and mini-SimCell using a modular surface display system to enable antigen recognition and selective binding to target pathogens.
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Mar 23
How do Gram-negative bacteria evade BamA-targeting antibiotics? Envelope stress (BaeSR) activates BamK, a BamA paralog, restoring outer membrane protein folding and growth in #Klebsiella. This #mBio study offers new insights for #antibiotic design. doi.org/10.1128/mbio.03497-2…
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