Pleased to share our latest study using super resolution to show that a pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia by the amazing Dr Mirfakhar 🔬🧫 nature.com/articles/s41467-0…

RT @CGCHenderson: Congrats to Tiger Jian on leading this innovative study advancing vascularized human organoids for therapeutic testing. G…

Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @NatureComms, here's a thread 🧵 shorturl.at/OD89x

Consider collab. w. Arlotta Lab, (Harv.) they have had multi-cell organoids (neuro) for some time are prob. interested in implementing vascularization. Best of luck!

Check this one out!

Congratulations to Dr. Keiran Campbell, investigator at LTRI, on receiving the Canadian Society of Molecular Bioscience’s New Investigator Award (@CSMB_SCBM), recognizing his achievements and leadership in computational cancer biology 👏 #SinaiHealth #LTRI #CancerResearch

This is fascinating! By introducing physiological vascular flow in vitro, you're opening new avenues for understanding how hemodynamic forces shape vascular architecture. Have you observed any significant differences in the vascularization of organoids compared to native tissues? And how might these insights help in developing treatments for Hereditary Hemorrhagic Telangiectasia? For more on such exciting biomedical topics, check out Sci-Quest, a one-stop platform to generate comprehensive reviews: sciqst.com #VascularBiology #Medicine #BiomedicalResearch

Perfusing lab-grown mini-organs revolutionizes the current model systems. Grateful to be part of this incredible team at @SinaiHealth and @UofT. Credits: @tigerhzjian @CallumJStirton @PelletierLab Check out our preprint for more exciting science: lnkd.in/eXwi7NtY

First time I’ve seen real scientific figures that look like those absurdly inaccurate magical science clips shown in movies or tv series. Kudos to the authors for making them so attractive! -and for their paper, of course-

Incredible stuff from Tiger in Pelletier lab

Cool! You could likely use in silico models made by Peter Balogh and Prosenjit Bagchi to predict capillary dynamics and RBC partitioning, then use your vascularized organoids to test their predictions. @PBNeuroVascLab

Exactly what the field needs! Without vascular flow, organoids lack critical mechanical cues. Your pump-integrated platform solves this with elegant simplicity. Outstanding work! 👏

(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.

(1/7): New preprint from the lab! We generate physiological vascular flow in vitro to vascularize organoids, interrogate the effects of hemodynamic forces on vascular architecture, and model the disease Hereditary Hemorrhagic Telangiectasia.