We have released three new modules: (1) Quick Bilayer, (2) Hybrid ML/MM Modeler, (3) Covalent Ligand Docker. Some video demos for (2) and (3) will be available this week.

Introducing La-Proteina, a generative AI model that creates complete atomistic protein structures together with their amino acid sequences, scalable upto 800 residues. Built by @NVIDIA Research, in collaboration with @UniofOxford and @Mila_Quebec La-Proteina addresses a key challenge in protein design by generating both backbone and side-chain atoms in a single unified process. It uses a hybrid architecture that models alpha-carbon coordinates while encoding sequence and side-chain details in latent vectors for every residue. @DidiKieran @karsten_kreis @tomasgeffner @ArashVahdat

By investigating the role compounds produced by cyanobacteria gene clusters play in freshwater ecosystems, research by @PhilmusLab of @OSUPharmacy will support the development of predictive models of microbial behavior in terrestrial-aquatic interfaces. jointgeno.me/FY25FG

RFdiffusion2 is now live! github.com/RosettaCommons/RF… You can now design proteins, and in particular enzymes from just partially defined amino acid side chains, and without defining their sequence position or order! Great job @r_krishna3 @woodyahern @dougtischer and everyone else!

Our department is hiring! The Department of Chemistry at the University of Utah invites applicants for two tenure-track faculty positions at all ranks in the areas of 1) Biological Chemistry broadly defined and 2) Experimental Physical Chemistry. utah.peopleadmin.com/posting…

🚨We have a job opening to join our team! We're looking for a highly motivated and talented natural product chemist 👩‍🔬👨‍🔬🧪at the #postdoctoral level with experience isolating natural products from fungi 🍄and plants🪴using HPLC, MS/MS, and NMR techniques: lnkd.in/g_554y2w

Please RP🙏 We are still looking for faculty candidates in the areas of chemical biology, biological chemistry, or pharmaceutical sciences at @CityUChem. Join us in vibrant Hong Kong, a global hub for innovation and culture!　cityu.edu.hk/hro/en/job/curr…

For PhD students in my network, @nvidia is now accepting applications for our graduate fellowship program. If you are working on topics across AI, life sciences, healthcare and HPC - consider applying. blogs.nvidia.com/blog/applic…

Please check out our lab's latest publication in Journal of Natural Products @pharmacognosy. It's a really fun story of chemical ecology and specialized chemistry. I'm grateful to Shiwei Chen and the other co-authors. pubs.acs.org/doi/full/10.102…

Identification of a L‐threonine‐utilizing hydrazine synthetase for thrazarine biosynthesis in Streptomyces coerulescens MH802‐fF5 - Shikai - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibra…

Ketosynthase Domain Catalyzes β-Lactonization in the Biosynthesis of the HMG-CoA Synthase Inhibitor Hymeglusin | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

We’re hiring postdocs in the Shen Lab! We're seeking candidates with expertise in: 🧪 Natural product discovery 🧬 Genome mining ⚗️ Synthetic chemistry & biocatalysis (esp. for ADCs) Interested? Email Professor Shen with your CV references: 🔗 explore.jobs.ufl.edu/en-us/j…

Video: How the Big Beautiful Bill will degrade science, public safety, and the US economy. open.substack.com/pub/writes… I made a video to show how NIH-university partnerships benefit society, and how Trump Administration policies have dismantled this essential pipeline.

Check out our new preprint! We examined sources of variability of transgene expression in N. benthamiana agroinfiltration and ways to minimize it. Graduate student Sophia Tang observed FP expression in >1,800 plants over the course of nearly 3 years! biorxiv.org/content/10.1101/…

Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a thread 1/x.. nature.com/articles/s41586-0… With amazing coauthors @Sattely_lab @ctliu629 @fordycelab @Stanford_ChEMH @StanfordEng

Recombinant protein production remains more art than science. How can we "solve" the protein expression bottleneck? As proteins are involved in virtually every biotechnology process, this will transform the bioeconomy @erika_alden_d @Align_Bio sciencedirect.com/science/ar…

Looking for a microbial enthusiast to share their #MicrobialCentrism on my #MattersMicrobial podcast (microbe.tv/mm) on June 26th between 7AM - noon. I have been writing to people but not a lot of traction yet. Please spread the word? @asm.org #TheMicrobesYoullKnow

If you are a PhD student in microbial interactions or natural products that is displaced by this political bullshit and looking for a new lab, I have room for one (or potentially two) PhD students in my group in the fall when I move to UW. Feel free to reach out via email.

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Bioeng Custom Lab Hardware Turn Key Genetic Design Please RT 💚

antiSMASH 8.0 is here. Enjoy analysing gene clusters, chemistry, enzymes, regulation etc with improved capabilities. academic.oup.com/nar/article…