A neuroimmune circuit mediates cancer cachexia-associated apathy

Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical...

Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity

Nature Communications - How chronic stress causes cognitive rigidity remains unclear. Here, the authors show that stress disrupts error signals from the anterior insula to the prefrontal cortex...

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A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural...

A global screen for magnetically induced neuronal activity in the pigeon brain

How animals detect Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensing...

Tattoo ink induces inflammation in the draining lymph node and alters the immune response to...

Despite safety concerns regarding the toxicity of tattoo ink, no studies have reported the consequences of tattooing on the immune response. In thi...

Ventral striatal astrocytes contribute to reinforcement learning

Astrocytes influence synaptic plasticity and neuronal function through astrocytic calcium dynamics (ACD). However, astrocytes’ contribution to cognitive operations like reinforcement learning (RL)...

Do inhibitory interneurons encode information or just keep the rhythm?

Inhibitory interneurons may help encode the brain’s internal representation of space