Walter Benjamin Research Fellow @AdelmanLab @harvardmed; PhD @_WolfLab @Uni_WUE.
Joined October 2016
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14 Apr 2025
Thrilled to see my postdoc work @AdelmanLab on the Integrator (INT) now out @CellCellPress:We found that INT deficiency allows immature and unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes
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Apoorva Baluapuri retweeted
4 Jun 2025
A new study shows mutations in the Integrator complex — linked to cancers, blood disorders, neurodevelopmental abnormalities, and other diseases — cause chronic stress in cells bit.ly/4mIdFdF
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14 Apr 2025
Thrilled to see my postdoc work @AdelmanLab on the Integrator (INT) now out @CellCellPress:We found that INT deficiency allows immature and unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes
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14 Apr 2025
Amazing to see how this work connects defects in transcription elongation to chronic stress signaling and disease! Could targeting dsRNA or ISR pathways offer new therapeutic strategies for conditions caused by INT mutations? Fascinating implications for RNA biology and medicine!
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14 Apr 2025
Thanks to @Wagnerlab_RNA @khurana_lab and SchafferLab for the awesome collaboration that made this work possible! #RNA #StressResponse #RNA #GeneReg #stemcells #Genomics #GeneRegulation Check out the paper here: authors.elsevier.com/c/1kwzm….
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31 Mar 2025
Excited to be at @KeystoneSymp for first time ! Looking forward to plenty of science&fun at #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25 #RNA #GeneReg #GeneRegulation
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Apoorva Baluapuri retweeted
26 Feb 2025
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. cell.com/molecular-cell/full…
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22 Dec 2024
Join organizers @AdelmanLab, @helin_kristian to discuss emerging research @KeystoneSymp #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25
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Apoorva Baluapuri retweeted
3 Dec 2024
Delighted to share our #NightScience tale: "A tetramer of BCL11A is required for stable protein production & fetal hemoglobin silencing," in @ScienceMagazine. Co-led by Zheng Ge, Yin Maolu, & me, here’s a tweetorial about our puzzle-solving adventure! 1/7 tinyurl.com/2tpaaua3
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Apoorva Baluapuri retweeted
Very proud to have been awarded an ERC Consolidator grant for research on neuronal RNAs! Rock on, team!
3 Dec 2024
Wow. Congratulations to Valérie Hilgers (@hilgers_lab) 🎉! She has been awarded the prestigious ERC Consolidator Grant by @ERC_Research! More on her project on alternative processing of RNA molecules in neurons here: ie-freiburg.mpg.de/5985387/2…
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Apoorva Baluapuri retweeted
Looking for an exciting #PhD project in #molecularBiology? How about this question: what determines a gene's end? Most human genes have alternative ends, the choice of which is important for health and disease. Yet we still don't understand how this choice is made!
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Apoorva Baluapuri retweeted
31 Mar 2024
All the points in a single blog:
backscattering.blog/2024/03/…
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Apoorva Baluapuri retweeted
30 Jan 2024
Happy to announce the final version of our paper is now available @NatureComms!
nature.com/articles/s41467-0…
Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!
10 May 2023
I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors @hdzomer @geoffmnelson @AdelmanLab, Irene, Debarun, and Prabu!!
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Apoorva Baluapuri retweeted
2 Jan 2024
...and here is the official ad
👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇
23 Dec 2023
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20 Apr 2023
My RNA didn’t degrade, it just underwent a rapid unscheduled disassembly into nucleotides !!
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19 Apr 2023
Great to see the conclusions from a recent paper from our lab (Stein et al 10.1016/j.molcel.2022.10.004) so nicely recapitulated in a different system !!!
19 Apr 2023
Online Now: INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II dlvr.it/Sml3jr
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Apoorva Baluapuri retweeted
24 Mar 2023
So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY…
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Apoorva Baluapuri retweeted
3 Feb 2023
Integrator is a global promoter-proximal termination complex dlvr.it/Shtx7G
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Apoorva Baluapuri retweeted
31 Jan 2023
New therapies for a certain type of #pancreatic #cancer: Elmar Wolf @Uni_WUE is working on this. He has now received a €2 million ERC Consolidator Grant from the EU. Congratulations! #ERCCoG @_WolfLab @ERC_Research go.uniwue.de/wolf-erc
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Apoorva Baluapuri retweeted
11 Dec 2022
Another day, another #NRMCBResearchHighlight! 🥳 We highlight work by Elmar Wolf' and Martin Eilers's labs @Uni_WUE, recently published @Nature:
go.nature.com/3uIsfb7
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