An online resource for researchers studying prostate cells and prostate cancer. Part of the @STEMCELLTech Science News service.
Joined June 2010
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May 21
GIVEAWAY! ๐งก
Step into your lab in style with a pair of @STEMCELLTech science socks. ๐งฆ
To qualify, subscribe to any of the 20 science newsletters offered by STEMCELL Science News and let us help you find your next journal club article. ๐
Learn more: bit.ly/4sFyUzh
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Jun 12
With $250,000 in Cancer Prevention and Research Institute of Texas (@CPRITTexas) funding, Dr. Qin Feng is working to stop the progression of #ProstateCancer.
๐๏ธ bit.ly/4agWCej
Her research goal is to provide a new treatment option for prostate cancer patients, especially those resistant to current therapies. ๐
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Jun 10
Researchers led by Dr. Luke Selth (@LukeSelth) at @Flinders have shown that USP2 drives therapy resistance and aggressive tumor behavior in advanced #ProstateCancer by stabilizing multiple cancer-promoting proteins.
๐ฌ Read the @cddpress study: go.nature.com/4omOVcj
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Check out this new @NatRevUrol #review from the lab of Dr. Robert Bristow at @CRUK_MI!
It shows how single-cell and spatial #transcriptomics are uncovering #ProstateCancer heterogeneity, evolution, and treatment resistance.
๐ go.nature.com/3RZDsTJ
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We've got a new study from the lab of Dr. Mariana Cooke at @umiamimedicine!
They identified FARP1 as a key mediator of cMET-driven Rac1 activation, promoting #ProstateCancer cell migration and invasion through actin-rich protrusion formation.
Read thes study: bit.ly/4efWNaJ
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This perspective from the labs of Drs. Joanna Achinger-Kawecka and Susan Clark argues that treatment-resistant #ProstateCancer is driven in part by changes in the 3D organization and #epigenetic regulation of DNA.
๐งฌ Learn more: bit.ly/3QotM4H
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New work from the lab of Dr. Woojin An at @uscnorris shows that VprBP promotes #ProstateCancer growth by silencing tumor-suppressive genes through #H2APhosphorylation. ๐งฌ
Learn more: bit.ly/4vr762B
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๐ข New in @cddpress!
Scientists have identified a vulnerability in enzalutamide-resistant #ProstateCancer cells to ferroptosis and show that the arthritis drug auranofin may overcome resistance by targeting GPX4-dependent survival pathways.
Learn more: go.nature.com/4dY45zG
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May 29
Gain- and loss-of-function studies in human #ProstateCancer cells and mouse neuroendocrine prostate cancer (NEPC) #organoids confirmed that sirtuin 1 promotes NEPC, while pharmacological inhibition suppresses it. ๐งซ
Read the full study: bit.ly/4nToFGd
๐ #OpenAccess
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May 28
Congratulations to @UTKnoxville's Dr. Kondapa Naidu Bobba, who has been selected to receive the 2026 Young Investigator Award. bit.ly/4dPceq1
Jointly supported by @PCFnews and @SNM_MI, this award will support Dr. Bobbaโs research in radiopharmaceutical therapies to improve the outcomes for patients with metastatic #CRPC. ๐
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May 27
This @oncogenejournal paper uncovers the significance of the ribosomal protein S15-DDX21-SCD1 axis in #ProstasteCancer development, expanding the understanding of noncanonical functions of ribosomal proteins.
๐ Check it out: go.nature.com/4dLEOsu
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May 26
Clinical analysis revealed significantly increased pan-lactylated protein (Pan Kla) expression in #CRPC tissues compared to prostate cancer, accompanied by elevated lactate production and lactate dehydrogenase activity.
๐ Read the paper in @cddpress!
go.nature.com/3RvPbJA
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May 25
Using single-cell RNA sequencing of mice across pathological stages, scientists find an early neuroendocrine-initiating cluster marked by elevated HOXD11, conserved in human neuroendocrine #ProstateCancer.
Learn more: bit.ly/4fH2VLm
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May 22
A new #review from the labs of Dr. @GertMeerleer and Steven Joniau (@joniau) at @UZLeuven explores how advances in imaging and metastasis-directed therapies are reshaping the management of oligometastatic #ProstateCancer, while highlighting ongoing challenges in defining and optimizing treatment strategies.
๐๏ธ Learn more in @NatRevUrol: go.nature.com/4nNcQ4o
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May 21
๐ข New in @MCT_AACR!
Researchers led by Dr. Allen Gao at @UCDavisUrology have identified IGFBP3-mediated SphK1/S1P signaling as a key driver of #enzalutamide resistance in advanced #ProstateCancer and a promising target for overcoming treatment resistance.
Learn more: bit.ly/4dAPDh3
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May 18
Congratulations to @fredhutch's Drs. Pallabi Mustafi and Ruben Raychaudhuri, who received Young Investigator Awards from the Prostate Cancer Foundation (@PCFnews)! ๐คฉ
๐๏ธ bit.ly/4uUssFz
Learn more about their work investigating #epigenetic features of aggressive #ProstateCancer.
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May 15
๐ฅผ Scientists at @PKU1898 synthesized a first-in-class, orally bioavailable, non-RGD pan-ฮฑv/ฮฑ5ฮฒ1 #Integrin antagonist, C19-9N.
๐ bit.ly/4wqSeCR
By co-targeting oncogenic drivers and #TME vulnerabilities, C19-9N heralds a transformative therapeutic paradigm with profound clinical potential for aggressive #ProstateCancer. ๐
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May 14
This @jitcancer study, led by Huazhong University researchers is the first to map systemic immune dynamics after irreversible electroporation in #ProstateCancer using single-cell analysis.
๐ Read their findings: bit.ly/437q1Dp
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May 14
There are a number of studies that suggest the RAF-MEK-ERK-RSK cascade, a major #Oncogenic pathway, is activated in #ProstateCancer and this increases as the disease progresses. ๐ฅผ
Dr. @AdamSharpMedOnc and @ICR_London collaborators discuss. ๐ฃ๏ธ
๐ go.nature.com/4dG7hRv
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May 12
New in @jitcancer!
Targeting LGALS9 enhances DC-mediated CD8 T cell immunity and synergistically augments the therapeutic efficacy of tumor vaccines, representing a promising immunotherapeutic strategy for #ProstateCancer. ๐ฏ
๐ bit.ly/3PE3dIm
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