Research laboratory @DartmouthChem utilizing structural biology, biochemistry and cell biology to investigate the molecular mechanisms of selective autophagy.
Joined July 2015
- Tweets 205
- Following 150
- Followers 265
- Likes 300
9 Photos and videos
Pinned Tweet
20 Nov 2024
The RagusaLab is now on Bluesky. Come check us out at bsky.app/profile/ragusalab.b…
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Ragusa Lab retweeted
11 Nov 2024
Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x
tinyurl.com/c7szhtfa
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18 Nov 2024
We get so focused on research it can be hard to take a step back and listen to other peoples stories. Check out @dartmouth postdoc @SukrutKamerkar's excellent perspective on supporting one another, published in @ScienceMagazine .
science.org/content/article/…
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Ragusa Lab retweeted
16 Nov 2024
It's known that anionic lipid charge enhances alpha-synuclein's ability to bind membranes. But did you know that alpha-synuclein can preferentially bind to neutral membranes when they are full of packing defects?
Read about it in our latest preprint!
16 Nov 2024
Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Ragusa Lab retweeted
15 Oct 2024
Pleased to see our paper now published in Autophagy Reports!
Great work from all involved to discover more about how "protein ATG8ylation" works.
The big question is still "why?"
"ATG5 is dispensable for ATG8ylation of cellular proteins"
tandfonline.com/doi/full/10.…
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Ragusa Lab retweeted
5 Sep 2024
Come be my colleague! @DartmouthChem has an opening for an Associate/Full Professor in Materials Chemistry:
apply.interfolio.com/152869
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24 Sep 2024
Our work on the biochemical reconstitution of mitophagy initiation led by @Devika_An has been updated on bioRxiv. You can check it out at biorxiv.org/content/10.1101/…
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20 Dec 2023
New paper up on bioRxiv biorxiv.org/content/10.1101/…
Awesome work from @Devika_An demonstrating what types of tethering you can reconstitute with GUVs and liposomes in vitro.
She also shows that Atg11 can bind some membranes and recruit them to Atg32 coated GUVs.
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20 Dec 2023
Can you reconstitute tethering using three-color imagining to monitor protein localization at tethering sites in vitro? Yes!
Can you distinguish between membrane binding and tethering with a single assay? Yes!
Can you monitor tethering in real-time? Yes!
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Ragusa Lab retweeted
9 Jul 2023
I am very happy our DFCP1 story is out! Since many years, DFCP1 has been used as an omegasome marker, but its function was totally unknown. Here we show that DFCP1 is an ATPase required for selective autophagy.
Here are the main points of the paper:
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Ragusa Lab retweeted
23 Jun 2023
Excited to announce that the Gonzalez Lab (chem-gonzalezlab.com) will open its doors when I join @DartmouthChem as an Assistant Professor of Chemistry in Fall 2023! (1/3)
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Ragusa Lab retweeted
24 Jun 2023
Very happy to see our paper now online. Great work from Wenxin, Taki and our fantastic colleagues #autophagy #crick @wencyzh @Sci_Lipi
doi.org/10.7554/eLife.89185 @eLife
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12 Jun 2023
Huge congratulations to these three awesome Ragusa Lab Ph.D. students who all returned to Hanover to participate in graduation last weekend. Congratulations Dr. Bauer, Dr. Leary and Dr. Reinhart!
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Ragusa Lab retweeted
6 Jun 2023
Have a Ph.D. in organic chemistry but want to gain experience applying data science to reaction development? The Read Lab @DartmouthChem is hiring a postdoc! See readlaboratory.com for more info. Please RT. #chempostdoc
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Ragusa Lab retweeted
25 May 2023
Our paper is out! Congratulations to @Cassandra_Hayne @TheHayneLab @RobinStanleyLab at @NIEHS ! I had fun image processing this project! nature.com/articles/s41594-0…
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Ragusa Lab retweeted
10 May 2023
Super excited to share a review article by @Nguyen_T_Hieu and myself on Substrate and phosphorylation site selection by PPPs! sciencedirect.com/science/ar…
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Ragusa Lab retweeted
28 Apr 2023
.@tjolivas, Yumei Wu, @shenliang_yu, @TJ_MeliaLab et al. @YaleCellBio show that ATG9 vesicles are the membrane seed for mammalian autophagosomes using nanodisc technology bit.ly/3LBlFg4
@PDClab
@GuptaLab1
@1in_1uan
@em_guinn
@ShantaNag1
#autophagy
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Here is the upated article from our lab, published today. Great job @DabrowskiRahel and @susanna_tulli !
28 Apr 2023
🚨 I’m thrilled to announce that my PhD paper has just been published in @JCellBiol🥳🚨
We find that parallel phospholipid transfer by Vps13 and Atg2 determines the dynamics of autophagosome biogenesis 🍩
#Autophagy @GraefLab @UniCologne @Wautophagy
rupress.org/jcb/article/222/…
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Ragusa Lab retweeted
25 Apr 2023
🚨 Thesis Seminar Alert: Daniel Walsh (Supattapone Lab) will present his research today at 11am in Chilcott and on Zoom!
25 Apr 2023
Daniel Walsh will be delivering his PhD Thesis Presentation TODAY at 11:00 am. Join us in Chilcott Auditorium or online via Zoom.
geiselmed.dartmouth.edu/bioc…
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