Tumor Immunologist and Engineer @Stanford.
Joined November 2018
- Tweets 424
- Following 752
- Followers 1,383
- Likes 1,433
16 Photos and videos
Pinned Tweet
6 May 2022
Tumors spread to lymph nodes before they metastasize to distant tissues, but for over a century scientists have debated whether this matters. It does. Check out our paper online now @CellCellPress @CellPressNews
cell.com/cell/fulltext/S0092…
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If you're interested in hearing about lymph node metastasis, tumor evolution, T cells, and immunotherapy, check out this @theNCI forum tomorrow, featuring Mary Jo Turk, @naxerova, and Alexander Huang. events.cancer.gov/dcb/tdln #TDLNForums
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When tumors colonize lymph nodes, they induce a LOT of changes to the immune and stromal populations in the involved LN and beyond, throughout the induction of Metastatic Tolerance. Check out this great study and rich resource describing these changes. Congrats @Max_Haist !
Jan 30
Online Now: Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance dlvr.it/TQflcw
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Nathan Reticker-Flynn retweeted
Happy to share our latest @sigtrans_sttt commentary on two beautiful @Nature papers on #ferroptosis and #cancer. Kudos to these 2 teams for their beautiful work! @j_ubellacker @luciaborriell @FoxChaseCancer nature.com/articles/s41392-0…
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11 Dec 2025
Thanks to @NatRevImmunol and the @preprintclub for highlighting our recent study on divergent evolution and type I interferon
8 Dec 2025
Type I interferon at the crossroads of metastatic dissemination bit.ly/44XMMuS
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Evolution Under Therapy: Resistance Mechanisms—
Andrew J. Aguirre, Nathan E. Reticker-Flynn, Susan M. Rosenberg, and Kathleen Burkhardt addressed this topic in a plenary session at the AACR Special Conference on Cancer Evolution.
#AACRevol25 @RetickerFlynn @SusanRosenberg8
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Nathan Reticker-Flynn retweeted
21 Nov 2025
What if nature already has the optimal cytokine solution for T cell therapy, but we just haven’t found it yet? Check out our paper out today in Immunity on IL-9 as a naturally orthogonal cytokine ideally tuned for T cell therapy authors.elsevier.com/sd/arti…
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Nature research paper: Lymph node environment drives FSP1 targetability in metastasizing melanoma
go.nature.com/4oiPnY2
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Nathan Reticker-Flynn retweeted
10 Nov 2025
Thrilled to see Mario's work on FSP1 out, providing evidence in melanoma alongside lung cancer that there may be alternatives for targeting ferroptosis! Glad we could help with this work including providing our LN metastasis model for in vivo validation
Nature research paper: Lymph node environment drives FSP1 targetability in metastasizing melanoma
go.nature.com/4oiPnY2
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Nathan Reticker-Flynn retweeted
5 Nov 2025
Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @Nature @ThalesPapaG @nyugrossman @HarvardEpi
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
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Nathan Reticker-Flynn retweeted
5 Nov 2025
Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy.
Huge congrats to all authors!
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
#Ferroptosis #FSP1 #CancerResearch
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Evolution Under Therapy: Resistance Mechanisms—
Andrew J. Aguirre, Nathan E. @RetickerFlynn, @SusanRosenberg8, and Kathleen Burkhardt will address this topic in a plenary at the AACR Conference on Cancer Evolution (Dec 4-6; Albuquerque).
brnw.ch/21wWYfD
#AACRevol25
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21 Sep 2025
Tumors often metastasize to lymph nodes before distant sites, yet evidence suggests that distant mets can originate from unique clones. Is this divergent seeding random? No. Check out our newest @biorxivpreprint to learn how the mechanisms diverge and how to harness them for IO.
21 Sep 2025
I’m excited to share the first major story from my PhD today on the complex role of type 1 interferon in metastasis and immunotherapy!
This work was made possible with the support of @RetickerFlynn, Marcos Labrado, and the incredible protein engineer @grayerodriguez
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21 Sep 2025
See the tweetorial from @CortBreuer ☝️and the preprint 👇
biorxiv.org/content/10.1101/…
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Nathan Reticker-Flynn retweeted
13 Aug 2025
Pleasure to share a tremendous body of work from @YangZhao102, who led the next chapter of the powerful orthogonal IL-2 technology from the Garcia Lab (where the innovative spirit is unmatched).
Grateful for this ongoing collaboration, stay tuned for more. rdcu.be/eACgC
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Nathan Reticker-Flynn retweeted
13 Aug 2025
Excited to see our protocol out today on spontaneous and experimental models of LN metastasis in @NatureProtocols! Though a straightforward system conceptually, getting these models working reliably took more time than originally expected so I hope this is a resource to everyone.
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13 Aug 2025
Interested in studying lymph node metastasis? Check out our protocol by @CortBreuer out today in @NatureProtocols
13 Aug 2025
New Article! Spontaneous and experimental models of lymph node metastasis bit.ly/3UtfcHF
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13 Aug 2025
If you're interested in trying out these protocols in your own lab, we are making the cell lines available through @CancerToolsOrg
cancertools.org/cell-lines/n…
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13 Aug 2025
And if you're interested in investigating what is happening in the lymph fluid itself, check out this great protocol by the Ubellacker Lab
nature.com/articles/s41596-0…
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3 Jul 2025
Congrats to Cort on this excellent F31 application and his fantastic science behind it!
2 Jul 2025
Thrilled to receive the NoA today for my NCI F31 fellowship! This award will fund the completion of my work on tumor-immune coevolution.
It's been a long road since I submitted it nearly a year ago but it's a positive note amidst the uncertainty in the rest of science right now
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