cancer immunology - sarcoma - melanoma - radiation oncology - kalbasilab.org @stanford
Joined May 2012
- Tweets 274
- Following 416
- Followers 704
- Likes 1,857
6 Photos and videos
Anusha Kalbasi retweeted
Highly anticipated data with first in class modified TIL therapy that does not use IL2, has lower dose lymphodepleting chemo - single arm ph1/2 OBX-115 in refractory metastatic melanoma #ASCO26 @DrBetofMDPhD @StanfordCancer
ORR 67% w 2 CR (!!)
DoR not reached (1 to 14 m)
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Anusha Kalbasi retweeted
SCI member @xrtcell & others show that combining targeted #RadiationTherapy with an experimental immune-boosting drug (BO-112) & anti-PD-1 therapy before surgery may help the immune system fight aggressive #SoftTissueSarcomas. brnw.ch/21x2SeG
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Anusha Kalbasi retweeted
May 14
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.64898…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
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May 7
If you haven’t REAP’d, have you really lived?
May 7
Autoantibodies cause autoimmune disease, shape infection outcomes, and alter cancer immunotherapy. But what role might they play in neuropsychiatric disease? In our new preprint, Katlyn Nemani and @JillianRJaycox take on this question in schizophrenia. 🧵
biorxiv.org/content/10.64898…
ALT https://www.biorxiv.org/content/10.64898/2026.05.04.722731v1
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Mar 31
Radiation is a powerful anti-cancer agent, but I considered it a weak immunomodulator. Our new study @CD_AACR changed my mind: in the right context, RT can incite potent systemic immune responses in patients (even rare irAEs). Which context? brnw.ch/21x1b6E
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Mar 31
Congrats to first author @JieDeng (my first post-doc, now leading her own group), UCLA Sarcoma program, and our @StanfordMed team on rich correlatives (@AasthaPal
@Stef_Tst @ZinaGood @aaronmring @everettmoding) /9
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Made possible by Marisol Quintero & team @Highlight_HLT, @theNCI, @StanfordCancer, @ConquerCancerFd, @UCLAJCCC. And most importantly, our patients. /10
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Anusha Kalbasi retweeted
Thrilled to share the primary focus of my PhD thesis work, now out in @ScienceMagazine today!
We developed Trikines — engineered cytokines that reconfigure receptor complex assembly to reshape signaling directly in endogenous immune cells.
doi.org/10.1126/science.adx9…
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4 Dec 2025
thanks @JoeFraietta and Janna for having me on!
In our latest episode of #ImmunoLogic, the hosts spoke with Anusha Kalbasi, MD (@xrtcell, @stanford) about his research on IL-9 and CAR-T
#Oncology #Immunotherapy @PennMedicine @JoeFraietta
Watch now:
hubs.li/Q03WB7TD0
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Anusha Kalbasi retweeted
24 Nov 2025
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @MarkYarchoan & @pogorely nature.com/articles/s41591-0… & nature.com/articles/s41592-0…
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Anusha Kalbasi retweeted
21 Nov 2025
IL-9 enhancement of engineered CAR-T therapies
@ImmunityCP @carlhjune @msofiacastelli
@Penn @xrtcell @stanford @KaylaKulhanek
cell.com/immunity/fulltext/S…
cell.com/immunity/fulltext/S…
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Anusha Kalbasi retweeted
21 Nov 2025
Engineering T cells (CAR T) for treatment of solid cancers has had mixed success to date. Two reports today raise the promise of using interleukin-9 as a way to raise efficacy @ImmunityCP
cell.com/immunity/fulltext/S…
cell.com/immunity/fulltext/S…
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21 Nov 2025
What if nature already has the optimal cytokine solution for T cell therapy, but we just haven’t found it yet? Check out our paper out today in Immunity on IL-9 as a naturally orthogonal cytokine ideally tuned for T cell therapy authors.elsevier.com/sd/arti…
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21 Nov 2025
What’s next? We are working our way to the clinic. And with support from @NIH, @CancerResearch and @parkerici, we are deep under the hood of JAK/STAT signaling in cancer immunotherapy. If you are a prospective post-doc and this work captured your interest, please reach out!
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