A proposed cancer center in Redwood City would combine patient care and research. The city will receive a formal updated project description, and Stanford Medicine will host two community webinars. brnw.ch/21x3f0A
SCI member Michael Lin & others developed MIDAS, a rapid protein-engineering platform that could accelerate cancer drug & diagnostic development by helping researchers quickly build & test thousands of protein variants in mammalian cells. #Bioengineeringbrnw.ch/21x3blA
SCI member @summerhanlab & others found that in #EGFR mutant advanced #NSCLC treated with EGFR-TKIs, patients with lower tumor burden had better overall survival, suggesting tumor burden may help predict outcomes and guide treatment decisions. brnw.ch/21x37PG
SCI member Mindie Nguyen & colleagues found cfDNA HelioLiver Dx blood test outperforms ultrasound for early #HepatocellularCarcinoma detection, showing superior sensitivity and non-inferior specificity vs MRI gold standard. brnw.ch/21x30mb
An international framework, developed by a global team including SCI member @cncurtis, guides clinical translation of molecular classifiers in #osteosarcoma, highlighting pre-treatment ctDNA for implementation, with other biomarkers needing validation. brnw.ch/21x2WqI
SCI member @xrtcell & others show that combining targeted #RadiationTherapy with an experimental immune-boosting drug (BO-112) & anti-PD-1 therapy before surgery may help the immune system fight aggressive #SoftTissueSarcomas. brnw.ch/21x2SeG
Ronald Castellino, pioneer in oncologic radiology, dies at 88. Castellino founded the first #RadiationOncology division at Stanford , led the diagnostic radiology department, and made important contributions to research in imaging the lymphatic system.brnw.ch/21x2JP5
SCI member Beth Beadle & others report that in p16 #OropharyngealCancer, quality of life outcomes at 6 months were similar for accelerated radiation with cisplatin or cetuximab, with persistent issues in dry mouth, sticky saliva, and senses. brnw.ch/21x2JOy
SCI member Chris Garcia & others use catch-bond engineering to enhance weak TCRs, boosting TCR potency against prostate cancer antigens while maintaining specificity. This strategy could overcome immune tolerance and improve TCR-based #CancerImmunotherapy. brnw.ch/21x2D6I
SCI member Nathanael Gray & others report that TRAP-1, a mutant-specific small molecule, activates p53Y220C via a ternary complex, restoring tumor suppressor function and inducing senescence and apoptosis in cancer cells. brnw.ch/21x2B1m#DrugDiscovery
SCI member Lei Qi & others show that engineered trogocytosis enables programmable #MacromoleculeDelivery, allowing tunable, cell-specific transfer of therapeutic proteins and genome-editing tools across diverse cell types. brnw.ch/21x2wNv#ProteinDelivery
A multidisciplinary expert thoracic panel, including SCI members Joel Neal and Joseph Shrager, released 19 consensus recommendations on managing locally advanced #LungCancer, covering resectability, neoadjuvant, and adjuvant therapies. brnw.ch/21x2sDC
SCI Esther John & others found that adding polygenic risk scores (PRS) to mammographic density (MD) didn’t improve contralateral #BreastCancer (CBC) risk prediction. MD remains the main predictor for CBC risk. brnw.ch/21x2obk
SCI member @AaronNewmanLab & others report a machine-learning framework identifying nine #SpatialTME ecotypes in the TumorMicroenvironment, linked to immunotherapy response and detectable in plasma cfDNA. brnw.ch/21x2iAF
SCI member Marvin Langston & others found that renal cell carcinoma incidence >, particularly among Hispanic, Black, and low-nSES groups. While overall mortality <, these groups faced > death rates, highlighting #RCC health equity concerns. brnw.ch/21x2frh
A @STS_CTsurgery panel, including SCI member Joe Shrager, developed 19 consensus recommendations on managing locally advanced #NSCLC, focusing on resectability, the role of neoadjuvant & adjuvant therapies, & multidisciplinary treatment approaches. brnw.ch/21x2bhI
SCI member @SurbhiSidanaMD & others found that high #BCMA expression at baseline predicts better outcomes with BCMA CAR-T therapy in #MultipleMyeloma. However, BCMA expression often decreases at relapse, which may impact future treatment strategies. brnw.ch/21x272Z
SCI member @l_schapira & others found that in young female cancer survivors, fear of cancer recurrence (FCR) predicts future chronic pain, but pain does not predict FCR. brnw.ch/21x22Yt