Postdoc in the @FritzLaylin lab. Fascinated by obscure protists. Evolutionary Cell Bio research via amoebae, cytoskeleton & diverse morphology. she/her.
Joined July 2018
- Tweets 245
- Following 487
- Followers 392
- Likes 1,757
37 Photos and videos
Pinned Tweet
17 Nov 2025
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s, which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
cell.com/current-biology/ful…
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Sarah Guest retweeted
19 Sep 2025
Plant developmental genes share functions & expression, but align orthologs' promoters and often… no conservation. Or is there?
In our new preprint, we show that conservation exists and is ancient, but was just obscured by genome complexity.
biorxiv.org/content/10.1101/…
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Sarah Guest retweeted
15 Dec 2024
.@fluoroforce, @pwoakes @myosincity et al. demonstrate subcellular biophysical mechanisms that enable #myosin 2 filament assembly. hubs.la/Q02_5lWN0
Part of the Year in Cell Biology: hubs.la/Q02_5CFd0
#CellBio2024
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Sarah Guest retweeted
2 Dec 2024
If you like Wallace's tweetorial and are going to ASCB, look out for my talk Tues. Dec 17th on how the microtubule cytoskeleton dictates RNA regionalization in Stentor!
#cellbio2024 #stentor #protist #NIHMOSAIC
2 Dec 2024
Where does pattern come from inside cells? in this revised preprint, @aralbright93 shows that regionalization of mRNA in a Stentor cell depends on dynein motors and the microtubule cytoskeleton
doi.org/10.1101/2023.01.09.5…
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Sarah Guest retweeted
31 Oct 2024
Happy Halloween!
For night 31 of #31NightsOfHalloween #Microscreepy, here is a grand finale video!
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Sarah Guest retweeted
28 Oct 2024
For night 28 of #31NightsOfHalloween #MicrosCreepy,
IT'S ALIVE! These are reanimated cell "ghosts," which are cells that have had their membranes/cytoplasm washed away, leaving the cytoskeleton behind. Adding ATP activates myosin motors, which causes contraction!
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Sarah Guest retweeted
24 Oct 2024
For night 23 of #31nightsofhalloween #MicrosCreepy,
here’s a blebby amoeba! I overlaid several frames of a movie into the same image, so you can see the motion of the cell (inverted phase contrast) and its mitochondria (purple/pink/yellow).
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Sarah Guest retweeted
18 Oct 2024
Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉
See you in Woods Hole! mbl.edu/courses
ALT a list of all the 2025 Marine Biological Laboratory Advanced Research Training Courses with course dates and application deadlines listed.
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Sarah Guest retweeted
21 Oct 2024
ICYMI: our effort to convince you that ExM has the potential to completely transform microbial ecology and protistology. We’ve only focussed on the cytoskeleton thus far - come join us and we can explore your favourite organelle/species/clade together! #PlanExM #ExpandEverything
21 Oct 2024
Thrilled to share this: hand to hand with the amazing @F_Mikus and @HiralABShah , with incredible guidance from @CentrioleLab , @Dey_Gautam , and @dudin_o , we’ve unlocked the cytoskeletal secrets of 200 protists! 🦠 #protists #PlanExM #UExM 👇biorxiv.org/content/10.1101/…
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Sarah Guest retweeted
19 Oct 2024
For night 19 of #31NightsOfHalloween #MicrosCreepy, here are some amoebae huddling together. The blinking you’re seeing is the contractile vacuole filling and emptying—this is how many pond-dwelling protists deal with fresh water rushing through the membrane due to osmosis.
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Sarah Guest retweeted
15 Oct 2024
We were fortunate to have @Sarahmoeba leading Microscopy Monday yesterday! She gave a talk on original microscopy techniques used for evolutionary significant but understudied protists. 🦠🔬💚
#Microscopy_Monday_Howard_University
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Sarah Guest retweeted
7 Oct 2024
First molecular data on Pocheina (Acrasidae, Heterolobosea). This paper represents a very long journey, starting with a mistake I made as a PhD student.
biorxiv.org/content/10.1101/…
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Sarah Guest retweeted
7 Oct 2024
For night 6 of #31NightsofHalloween #MicrosCreepy,
here’s a monster of an amoeba with 6 nuclei!
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Sarah Guest retweeted
4 Oct 2024
For night 3 of #31NightsofHalloween #MicrosCreepy, here are some cells spilling their guts
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Sarah Guest retweeted
4 Oct 2024
For night 4 of #31NightsofHalloween #MicrosCreepy, here is a scary alien! Or, an amoeba imaged by Scanning Electron Microscreepy.
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3 Oct 2024
Not pictured, the timestamps showing how long I waited between each message.
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Sarah Guest retweeted
2 Oct 2024
For night 2 of #31NightsofHalloween #MicrosCreepy, here is a video of amoebae crawling on a glass coverslip. These cells were imaged by IRM, which shows only the area of the cell in closest contact with the coverslip (like footprints!)
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Sarah Guest retweeted
1 Oct 2024
It’s that time of year again— #31NightsofHalloween #MicrosCreepy!
For night 1, here are some amoebae stained for actin polymer 🧡
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6 Sep 2024
Happy Friday! I hope you get a chance to go on a little adventure this weekend, like these exploring amoebae carving trails in their bacteria lawn.
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Sarah Guest retweeted
25 Aug 2024
Cell 1: I am going this way.
Cell 2: No, come this way with me.
Cell 1: Where are we going?
Cell 2: No clue, but at least we will be together.
Some that wander are lost........
#CellBiology
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