Group based @BabrahamInst in Cambridge. Interested in #phosphatases. She/her. Now on BSky - see you over there.
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ALT Sixth form conference 2024 theme: proteostasis
ALT Image shows three immunofluorescent images of mouse colons stained for nuclei (DAPI;blue) and cellular junctions (ZO1; green). Text reads: News - Research sheds light on the role of PTPRK in tissue repair and cancer
ALT Heatmap showing differential gene expression between WT and PTPRK KO HT29 cells that was rescued by reintroduction of PTPRK and/or PTPRK.RQ. Graph of Gene ontology (GO) analysis of genes suppressed by PTPRK showing an overrepresentation of genes annotated with the biological processes ‘epithelial to mesenchymal transition’ and ‘mesenchymal cell differentiation’, as well as Wnt signalling. Amongst genes that were upregulated by PTPRK, GO analysis revealed overrepresentation of genes annotated with the terms ‘negative regulation of epithelial cell proliferation’ and ‘regulation of cell migration’. Also, graph showing a ∼2-fold upregulation of Ptprk in organoids treated with TGFβ1 in the RNA-seq data from two out of three published studies. Finally, a graph showing that organoids mutant for P53 and KRas harbouring the Notch1 ICD showed significantly reduced levels of PTPRK.
ALT Inset image of Dr Hayley Sharpe, set over a false-coloured image of phagocytic primary macrophages expressing a fluorescent reporter to detect cellular hydrogen peroxide production (shown by yellow/orange colouring). Text reads: News - Dr Hayley Sharpe receives an ERC Consolidator Grant
