Molecular labeling for biology and medicine. PI at Shanghai Institute of Biochemistry and Cell Biology.
Joined November 2020
- Tweets 93
- Following 362
- Followers 565
- Likes 387
3 Photos and videos
Pinned Tweet
10 Sep 2025
Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples.
nature.com/articles/s41586-0…
14
97
617
42,544
Shuo Han retweeted
May 15
Out today!
CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8 T cells by binding to phosphatidylserine, inhibiting antitumor immune responses and revealing a targetable checkpoint pathway
nature.com/articles/s43018-0…
2
12
21
2,583
May 14
cen.acs.org/people/profiles/… Really honored and thrilled to be selected for 2026 C&EN Talented 12 of the American Chemical Society. Look forward to the award symposium at the ACS fall meeting in Chicago! We excited to push proximity labeling chemistry further into therapeutic space!
1
19
541
Shuo Han retweeted
Jan 8
Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states
CB part starts at 14:55
youtube.com/watch?v=4v_ZqWoA…
Thanks to @PeterECavanagh and Andrew Xue – amazing graduate students who co-led this work
2
14
100
12,058
Shuo Han retweeted
Jan 8
Can we design mutations that predictably bias proteins towards desired conformational states?
Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
science.org/doi/10.1126/scie…
14
199
856
140,580
Shuo Han retweeted
11 Jul 2024
Huge congrats to @Raiseemhigh and all collaborators @BroadProteomics @aliceyting @Shuo_Han_ @StanfordBrain @HHMINEWS @HHMIJanelia!
(Sneak in an ad: my lab at Janelia is seeking a highly motivated postdoc interested in kidney physiology. Pls share!)
cell.com/cell/fulltext/S0092…
8
37
4,663
Shuo Han retweeted
18 Aug 2023
Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday
nature.com/articles/nmeth.40…
1
85
591
56,820
29 Jun 2023
Lots of fun at our first lab outing and my first foray into poetry 😂
1
30
3,347
The FASEB BioAdvances journal team would like to welcome new Editorial Board member @Shuo_Han_ of the Shanghai Institute of Biochemistry and Cell Biology! Welcome aboard! bit.ly/42Z8OK2 #FASEBBioAdvances
1
1
3
1,374
Shuo Han retweeted
14 Dec 2022
Our work on ENTER is finally out @CellCellPress! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications:
⭐️Decode Ligand-Receptor interaction
⭐️Receptor-specific cargo delivery
⭐️Link receptor specificity with cell state at single cell
8
97
453
Shuo Han retweeted
8 Dec 2022
Woohoo! Big congrats to @JiaqiShen1, @LequnGeng and Xingyu Li for all their collaborative work leading to a brand new publication in @naturemethods! Our group teamed up with Prof Peng Li’s Lab 👏🏻!!! (@UMLifeSciences & @UMichDentistry) nature.com/articles/s41592-0…
4
7
66
Prostate cancer occurs more frequently at the peripheral zone (PZ) than in transition zone (TZ) prostate, but the underlying mechanism is unclear. Study by Dr. Deyong Jia in my lab at @NatureComms provides one explanation for this clinical observation. doi.org/10.1038/s41467-022-3…
6
17
70
22 Sep 2022
Thanks a ton to @DamonRunyon for organizing our amazing retreat! Fantastic talks from all fellows and really inspirational career advice from former alum @ValerieJHorsley. Also visited many friends and mentors at MIT Chem first time since I left 2016. See you next time Boston!
1
41
Shuo Han retweeted
18 Aug 2022
CRISPR can cut DNA and RNA, but did you ever wonder other activities might exist? Today in @biorxivpreprint, we show that the Type III-E Cas7-11 system programmably activates a nearby protease as part of microbial defense. @jgooten @hnisimasu 🧵👇🏼biorxiv.org/content/10.1101/… 1/9
4
41
201
Shuo Han retweeted
18 Aug 2022
You know CRISPR complexes can cut DNA/RNA….what if some of them cleaved proteins too?
Today in @biorxivpreprint, we ( @omarabudayyeh @hnisimasu) continue our study of Cas7-11 and type III-E systems, revealing a new triggered protease function
biorxiv.org/content/10.1101/… 1/6
4
151
594
Shuo Han retweeted
With more grants coming, we are excited to recruit postdocs who are interested in regenerative biology and extreme physiology. Some recent pubs and reviews here: bit.ly/3zqWQtV, tinyurl.com/y72afknn, tinyurl.com/2fp9ppew, tinyurl.com/59xdfjry Please RT.
4
64
172
I will start building my lab this summer in the brand new @westlake_uni, and we are hiring at all levels. Come join us to create protein-based synthetic intelligence: chenlab.org
35
54
308
22 Jun 2022
Highly recommend! Ken is a wonderful scientist and mentor! A fantastic choice if you are interested in applying cutting edge chemical biology tools to studying molecular physiology!
22 Jun 2022
Excited to announce that the Loh lab will open in August @YaleWestCampus’s Institute for Biomolecular Design and Discovery! Our lab will use chemo-proteomic tools to study peripheral neurobiology in adipose tissue and the pancreas. We are hiring at all levels, please DM!
4
Shuo Han retweeted
13 Jun 2022
Thank you again to all of the attendees @epiSCniche_GRC! We are building a strong, inclusive, and welcoming community of exceptional #stemcell researchers. It was a privilege to organize this meeting together with @ValerieJHorsley, and I hope to see all of you again in two years.
3
36
Shuo Han retweeted
24 May 2022
As a beautiful sequel to @JiefuBiol & @Shuo_Han_’s 2020 Cell paper describing cell surface proteome profiling in vivo, this new paper by @chichi_xie & Liqun Luo et al. performs cell surface proximity labeling in WT vs. Acj6 knockdown flies, to discover...
tinyurl.com/3rrzfccw
1
3
47