Posting our lab life studying the neuronal cytoskeleton and chromatin with cool microscopesπ¬Proud #GenX, #firstgen college, #intj @RITscience @stonybrooku Alum
Joined September 2019
- Tweets 5,291
- Following 3,151
- Followers 4,168
- Likes 41,803
1,451 Photos and videos
Pinned Tweet
Thrilled we finished this 8 yr study w/@NeuroCellPress Wonder what oxygen, blood vessels, Hif1 has to do with cell polarity & neuron migration? Genetics, gaussian & lattice light-sheet crack the case! Cerebellar blood vessels in cyan #cellfie #Science
url:cell.com/neuron/fulltext/S08β¦
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David Solecki (pronounced so_lets_ki π) retweeted
Out now in Science! Our new study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.π§΅
science.org/doi/10.1126/scieβ¦
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David Solecki (pronounced so_lets_ki π) retweeted
Still one of the purest dopamine hits in science:
Thank you for your submission.
For one brief, beautiful momentβ¦ the paper is someone elseβs problem.
Reviewer 2 can cook me later. π₯
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David Solecki (pronounced so_lets_ki π) retweeted
Post-graduation jaunt through Santa Fe country. Beautiful enough to make you forget the altitude for a minute. Rattler skin reminder of who really runs the joint π³
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David Solecki (pronounced so_lets_ki π) retweeted
May 19
π₯ π New preprint! ππ₯³
How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order πͺ
π§΅π (1/17)
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Celebrating K1 graduating from college ππ₯³ππππΎ
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David Solecki (pronounced so_lets_ki π) retweeted
Mind-blowing cell action alert!
Watching vesicle cargo lanes light up like a
@FedEx highway in real-time under the #microscope.
Who knew that home-brewed phosphatidic acid live cell imaging probe would look so stunning in human fibroblasts?
Which organelle do you think its labeling? Drop your guess below!
Too late for #FluorescenceFriday but just in time for #MicroscopyMonday #scicomm #sciart #Science
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David Solecki (pronounced so_lets_ki π) retweeted
Turns out some virus's get stuck in late endosomes under high membrane tension! Making them unable to infect cells!
Congrats to the Tklab Virus Team for our paper @PNASNews. Live 3D LLSM imaging single cell infection assay! @harvardmed @BostonChildrens
pnas.org/doi/10.1073/pnas.25β¦
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David Solecki (pronounced so_lets_ki π) retweeted
May 8
We have developed a cysteine-free, highly thermostable tagging system, UTag, that enables single-mRNA translation tracking in live cells. You may wonder how different tagging systems affect translation kineticsβwe addressed this by performing a systematic comparison.
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David Solecki (pronounced so_lets_ki π) retweeted
π£ Preprint!! Hugely excited for this new direction, an ongoing collaboration with the talented labs of Zoe McElligott and Gina Leinninger. From the McElligott lab - Biased NTSR1 signaling regulates the extended amygdala and suppresses motivated feeding. π π©
Check it out π
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Somite Semaphorin 3A- Endothelial Neuropilin 1 cascade restricts developmental Angiogenesis in Zebrafish
Ectopic intersomitic vessel sprouting in mosaic nrp1a/b MOπ or nrp1a/b KOπ
β«EC mitosis
β¬EC migration from dorsal aorta/posterior cardinal vein
sFlt1-independent
Sema3aa/ab more enriched in ventral than in dorsal somites (24-48 hpf)
SEMA3A-NRP1βΆοΈEC cell body shrinkage CD31 loss
#Angiogenesis 2026
link.springer.com/article/10β¦
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David Solecki (pronounced so_lets_ki π) retweeted
Hey yβall π I need a little repost magic. π₯
The Solecki lab is recruiting MULTIPLE postdocs for a chromatin imaging project at St. Jude.
This work sits at the intersection of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis β and the eye-popping video below shows exactly why itβs so exciting.
This may be for you if you are:
β’ A neurobiologist who wants to become DANGEROUS in cell biology π§
β’ A chromatin biologist who wants to ditch endpoint molecular biology and actually watch nuclear states unfold in living cells π§¬
β’ An imaging scientist or biophysicist who wants to get messy in real cells, not idealized samples π¬
A quantitative mindset is required. Prior experience in every area is not.
If you ever imagined touring the nucleus like nuclear render and our Pol II biosensor below⦠reach out because WE can do it.
Tag a scientist who needs to see this RT to help us find them! π Letβs make chromatin biology history.
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David Solecki (pronounced so_lets_ki π) retweeted
If you are multi-disciplinary unicorn this is the position for you π€©
Hey yβall π I need a little repost magic. π₯
The Solecki lab is recruiting MULTIPLE postdocs for a chromatin imaging project at St. Jude.
This work sits at the intersection of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis β and the eye-popping video below shows exactly why itβs so exciting.
This may be for you if you are:
β’ A neurobiologist who wants to become DANGEROUS in cell biology π§
β’ A chromatin biologist who wants to ditch endpoint molecular biology and actually watch nuclear states unfold in living cells π§¬
β’ An imaging scientist or biophysicist who wants to get messy in real cells, not idealized samples π¬
A quantitative mindset is required. Prior experience in every area is not.
If you ever imagined touring the nucleus like nuclear render and our Pol II biosensor below⦠reach out because WE can do it.
Tag a scientist who needs to see this RT to help us find them! π Letβs make chromatin biology history.
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Hey yβall π I need a little repost magic. π₯
The Solecki lab is recruiting MULTIPLE postdocs for a chromatin imaging project at St. Jude.
This work sits at the intersection of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis β and the eye-popping video below shows exactly why itβs so exciting.
This may be for you if you are:
β’ A neurobiologist who wants to become DANGEROUS in cell biology π§
β’ A chromatin biologist who wants to ditch endpoint molecular biology and actually watch nuclear states unfold in living cells π§¬
β’ An imaging scientist or biophysicist who wants to get messy in real cells, not idealized samples π¬
A quantitative mindset is required. Prior experience in every area is not.
If you ever imagined touring the nucleus like nuclear render and our Pol II biosensor below⦠reach out because WE can do it.
Tag a scientist who needs to see this RT to help us find them! π Letβs make chromatin biology history.
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They say necessity is the mother of invention. We wanted to move beyond reference proteins to define chromatin structure and actually see epigenetic states in living cells. Hereβs our enhancer nucleosomes probe imaged and high speed. Unreal dynamics in living cells.
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Here is our transcriptional start (TSS) site biosensor in living cerebellar granule neurons. The puncta are not individual TSSs but collections of TSS grouped in a cluster.
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Some of you may not be aware of our foundational research using lattice light sheet microscopy, Janeliaβs CryoCLEM work flow from the Hess and Betzig labs and a few well picked standard live cell imaging probes to show how neuronal differentiation impacts chromatin
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