@Stahelin_Lab profile picture
Stahelin Lab @Stahelin_Lab

Laboratory at Purdue University using biochemistry and biophysics to study lipids and viruses. Drug development against viral hemorrhagic fevers. U2 fans!

Joined April 2018
  • Tweets 688
  • Following 2,869
  • Followers 1,536
35 Photos and videos
Candidates have been disclosed for the upcoming election for the American Society for Biochemistry and Molecular Biology. If you are an ASBMB member, don't forget to vote! #vote #asbmb #JLR #jbc asbmb.org/asbmb-today/people…

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Learn about the candidates running for ASBMB President, Secretary, Councilor, Nominating Committee and Publications Committee.

asbmb.org
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New publication! It was a wonderful collaboration with the lab of Juan Del Valle at Notre Dame. This would not be possible without his team and their peptide design. A constrained peptide that binds the Ebola virus matrix protein #ebola #VP40 #peptide pubs.rsc.org/en/Content/Arti…

Design of a stapled peptide that binds to the Ebola virus matrix protein dimer interface

The Ebola virus (EBOV) is a filamentous lipid-enveloped RNA virus that can cause viral hemmorhagic fever and has a high fatility rate. EBOV encodes seven genes including the lipid-binding matrix...

pubs.rsc.org
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I was very happy our work was chosen to the cover this month. Especially for former postdoc Souad Amiar and collaborator Andrea Marzi Cover - Journal of Lipid Research jlr.org/article/S0022-2275%2…

Cover

jlr.org
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Stahelin Lab retweeted
Steve Brohawn@SteveBrohawn
8 Nov 2024
Check out our new preprint! biorxiv.org/content/10.1101/… We found sphingolipid binding to SARS-CoV-2 M protein controls its conformation to coordinate viral assembly release. Great collaboration with @VothGroup @Stahelin_Lab co-led by @KimDolan_UCB, Mandira Dutta, @souadamiar.

Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly

M is the most abundant structural membrane protein in coronaviruses and is essential for the formation of infectious virus particles. SARS-CoV-2 M adopts two conformations, Mshort and Mlong, and...

biorxiv.org
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Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly New preprint in collaboration with the @SteveBrohawn @VothGroup Excellent team effort demonstrating a ceramide-1-phosphate interaction in M! #membrane biorxiv.org/content/10.1101/…

Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly

M is the most abundant structural membrane protein in coronaviruses and is essential for the formation of infectious virus particles. SARS-CoV-2 M adopts two conformations, Mshort and Mlong, and...

biorxiv.org
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Very pleased to announce a new review in Virology put together by Ph.D. student Rokaia Sultana. This article details the strenghts and limitations of virus-like particle systems for SARS-CoV-2 #virus #sarscov2 #lipid #virology sciencedirect.com/science/ar…
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Fatty acids and membrane order matter for assembly and budding of the Ebola virus matrix protein VP40! New work from the lab. Big thanks to Andrea Marzi! #ebola #lipidtime #membrane #VP40 #plasma_membrane jlr.org/article/S0022-2275(2…

A fatty acid-ordered plasma membrane environment is critical for Ebola virus matrix protein...

Plasma membrane (PM) domains and order phases have been shown to play a key role in the assembly, release, and entry of several lipid-enveloped viruses. In the present study, we provide a mechanistic...

jlr.org
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New collaborative work examining electrostatic interactions between the Ebola virus matrix protein VP40 and the plasma membrane at key arginine substitutions! pubs.acs.org/doi/10.1021/acs… #ebola #lipidtime #VP40 #membrane #filovirus

Ebola Virus Matrix Protein VP40 Single Mutations G198R and G201R Significantly Enhance Plasma...

Viral proteins frequently undergo single or multiple amino acid mutations during replication, which can significantly alter their functionality. The Ebola virus matrix protein VP40 is multifunctional...

pubs.acs.org
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The N (nucleoprotein) interacts with anionic lipids including phosphoinositides and phosphatidylserine. New work from the lab and collaboration with the lab of Greg Voth. #lipidtime #sars2 #membrane jbc.org/article/S0021-9258(2…

The SARS-CoV-2 nucleoprotein associates with anionic lipid membranes

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a lipid-enveloped virus that acquires its lipid bilayer from the host cell it infects. SARS-CoV-2 can spread from cell to cell or from...

jbc.org
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Collaboration with Dr. Elsje Pienaar's computational lab yields a better understanding of the Ebola virus nucleoprotein's role in virus budding. #Ebola #nucleoprotein #VP40 nature.com/articles/s42003-0…

Impact of Ebola virus nucleoprotein on VP40 virus-like particle production: a computational approach

Communications Biology - A computational modeling study indicates that relative amount and timing of Ebola virus proteins VP40 and NP drive effective viral particle production.

nature.com
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Collaboration with Dr. V. Jo Davisson's lab! New studies demonstrating potency and stability of diphyllin-derived Vacuolar-ATPase inhibitors #Virus #pH sciencedirect.com/science/ar…
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Stahelin Lab retweeted
Andrea Bauerfeind@mages05
23 Apr 2024
Abstracts Due 5/26!🌟 Explore the latest in #Phospholipid Biology at #LSHSRC! Join Antonella De Matteis @Tigem_Telethon and @VolkerHaucke in July for "Phospholipids in Aging and Disease." Topics: lipid signaling, treatments for diabetes, cancer, & more. bit.ly/3xQj5yp
For over 35 years, this Science Research Conference (SRC) has presented and integrated advances in phospholipid biology and signaling to foster new national and international collaborative projects. This year’s SRC will continue to encourage and support junior investigators, trainees, women, and minority scientists to pursue phospholipid biology research, ensuring that the study of human diseases relevant to aging remains vigorous. It will also accelerate the translation of fundamental advances into novel clinical treatments through the interactions of basic and clinical researchers. Presenters will explore all aspects of phospholipids, the major components of biological membranes, which play instrumental roles in guiding cell-to-cell communication and trafficking of nutrients and proteins.

ALT For over 35 years, this Science Research Conference (SRC) has presented and integrated advances in phospholipid biology and signaling to foster new national and international collaborative projects. This year’s SRC will continue to encourage and support junior investigators, trainees, women, and minority scientists to pursue phospholipid biology research, ensuring that the study of human diseases relevant to aging remains vigorous. It will also accelerate the translation of fundamental advances into novel clinical treatments through the interactions of basic and clinical researchers. Presenters will explore all aspects of phospholipids, the major components of biological membranes, which play instrumental roles in guiding cell-to-cell communication and trafficking of nutrients and proteins.

FASEB
@FASEBorg
18 Apr 2024
4 amazing keynotes under one roof! Join @ghotamis and @JLS_Lab with organizers @OlzmannLab and @HenneLab for #LIPDSRC plus @AntonellaDeMat4 and @VolkerHaucke with organizers @BrookeEmerling and @sharontooze01 for #LSHSRC. Register for one to attend both: hubs.ly/Q02sPfRB0
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Learn more about how the Ebola virus matrix protein (VP40) dimer is stabilized! A wonderful collaboration with the Wiest and Chapagain labs integrating computational work with in vitro and cellular studies. #ebola #vp40 #lipidtime #Virus onlinelibrary.wiley.com/doi/…

Computational and experimental identification of keystone interactions in Ebola virus matrix...

The Ebola virus (EBOV) is a lipid-enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV is regulated by the...

onlinelibrary.wiley.com
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Happy this manuscript is published, especially for Ph.D. student Bali Motsa. Demonstrates how 1 or -1 in charge (and more) can alter lipid binding, assembly, and budding of the Ebola virus matrix protein VP40. jbc.org/article/S0021-9258(2… #ebola #lipidtime #electrostatics #VP40

Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola...

Ebola virus (EBOV) is a filamentous negative-sense RNA virus, which causes severe hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment of EBOV, so it is import...

jbc.org
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New work from our collaboration with the lab of Dr. Elsje Pienaar at Purdue. A computational model of the Ebola virus matrix protein nucleation-elongation process! #ebola #lipidtime journals.asm.org/doi/10.1128…

Evaluation of fendiline treatment in VP40 system with nucleation-elongation process: a computatio...

Ebola virus (EBOV) infection can cause deadly hemorrhagic fever, which has a mortality rate of ~50%–90% without treatment. The recent outbreaks in Uganda and the Democratic Republic of the Congo...

journals.asm.org
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New work from the lab with integrated collaborative studies with Prem Chapagain's lab on the role of phosphatidic acid in assembly and budding of the Ebola virus. @AsbmbLrd #lipidtime #ebola #VP40 sciencedirect.com/science/ar…
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We are happy to have a new preprint online! Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles biorxiv.org/content/10.1101/…

Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of...

Ebola virus (EBOV) is a filamentous negative-sense RNA virus which causes severe hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment of EBOV, so it is important...

biorxiv.org
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Excited to have this work published in the Journal of Lipid Research! How PI(4,5)P2 binding sites in the Ebola virus matrix protein modulate assembly and budding! KAJ the rockstar! @KristenAnnaJoh1 @jlipidres @AsbmbLrd #lipidtime jlr.org/article/S0022-2275(2…
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RT @emily_david_: It’s Dr. Emily David, Ph.D.! This degree was made possible by the incredible support from my family and friends, my men…
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Stahelin Lab retweeted
Liana C Silva Lab@MolCellBiophys
13 Oct 2023
We had a wonderful week at Madeira! Thank you all for the great discussions at the FEBS Special Meeting on Sphingolipid Biology. It was a pleasure to host you all! #sphingolipidbiology #SLBiol2023 #visitmadeira @FEBSnews @EMBOevents @CoskunPLID @BassereauTeam @Stahelin_Lab
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