Cell Biology lab at UTSW @UTSWNews. We study lipid droplets and the organization of metabolism in cells.
Joined November 2018
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Important to celebrate trainee victories: excited to have @HollyMerta's paper out in @CellReports.
We use TurboID sub-organelle proteomics to map the ER network.
We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.
sciencedirect.com/science/ar…
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Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC
events.faseb.org/event/Lipid…
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So happy to host @RobertoZoncu at UTSW, who gave a spectacular seminar as part of our LMND series on lipids and organelles in neurodegenerative diseases. Thank you for visiting us Roberto!
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Henne_Lab retweeted
May 11
Great to see this Spotlight article in Trends in Cell Biology highlighting our recent identification of a lipid droplet quality control pathway in which FSP1 protects PUFA-rich neutral lipids from peroxidation, thereby suppressing ferroptosis.
cell.com/trends/cell-biology…
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Henne_Lab retweeted
May 5
Just published!! Congrat's to my post-doc Wang for getting featured on the cover of Science Signaling. So proud!! So much more to learn about phenotypic plasticity.
science.org/eprint/XZZZRR72V…
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Henne_Lab retweeted
You do not want to miss the 2026 FASEB #LipidDroplet conference! Abstracts are due May 31. Travel awards are available for trainees 👇
Summer is approaching & so is the 2026 Lipid Droplets: From Mechanisms to Disease FASEB SRC (July 26-30 in Scottsdale, AZ)!
Interested in lipids? Join this amazing summer research conference!
Abstracts due May 31,
Early registration June 14.
events.faseb.org/event/Lipid…
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Henne_Lab retweeted
COMMENT | NJ Færgeman (U of Southern Denmark)
Long-chain acyl-CoA esters are essential to virtually every aspect of lipid metabolism, yet they are underappreciated and deserve greater attention.
dlvr.it/TSLpT0
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Henne_Lab retweeted
May 4
Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer’s brains
nature.com/articles/s41556-0…
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Henne_Lab retweeted
Thank you @focalplane_jcs for highlighting our latest study!
#NCI #NIH #LiverZonation #Microscopy
focalplane.biologists.com/20…
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Henne_Lab retweeted
Looking forward to this 😍
Summer is approaching & so is the 2026 Lipid Droplets: From Mechanisms to Disease FASEB SRC (July 26-30 in Scottsdale, AZ)!
Interested in lipids? Join this amazing summer research conference!
Abstracts due May 31,
Early registration June 14.
events.faseb.org/event/Lipid…
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Summer is approaching & so is the 2026 Lipid Droplets: From Mechanisms to Disease FASEB SRC (July 26-30 in Scottsdale, AZ)!
Interested in lipids? Join this amazing summer research conference!
Abstracts due May 31,
Early registration June 14.
events.faseb.org/event/Lipid…
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Henne_Lab retweeted
New paper from the lab, lead by graduate student Liang Chen. Here, guided by genome-wide CRISPR screening, we demonstrated that either lipids have a big impact on the lysosomal function, especially under the storage disease conditions. link.springer.com/10.1038/s4…
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Henne_Lab retweeted
Apr 29
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s41586-0…
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James Olzmann (@OlzmannLab at @UCBerkeley) won the 2026 Avanti Award in Lipids. His work has advanced knowledge of lipid droplets, lipid metabolism & ferroptosis.
⏯️Watch his #ASBMB26 talk, "Guardians of the membrane": youtu.be/QJ5YOsUCuHQ
#LipidResearch @AvantiResearch
ALT James Olzmann stands at a podium with a laptop delivering a talk at the 2026 ASBMB Annual Meeting.
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Very interesting study examining links between key lysosome homeostasis proteins and neurodevelopment disorder.
New work from @MencacciLab et al, with contribution from @DePaceRaffa in our lab @NIH_Innovates, identifies pathogenic variants in BORCS5, encoding a subunit of the BORC complex, as a cause of a severe neurodevelopmental disorder with lysosomal dysfunction jci.org/articles/view/195336
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Henne_Lab retweeted
New work from @MencacciLab et al, with contribution from @DePaceRaffa in our lab @NIH_Innovates, identifies pathogenic variants in BORCS5, encoding a subunit of the BORC complex, as a cause of a severe neurodevelopmental disorder with lysosomal dysfunction jci.org/articles/view/195336
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Henne_Lab retweeted
Check out our highlight of the most recent example of subcellular mitochondrial specialization in @CurrentBiology. Be sure to also check out the beautiful work from David Sherwood's lab
cell.com/current-biology/ful…
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So happy to host Antonia De Maio from @CellPressNews as part of our LMND seminar series. Antonia spoke to trainees about the publishing career path, and gave a wonderful seminar about navigating academic publishing.
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Apr 17
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…
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Neuronal lipid droplet-derived lipids support neuron function by providing fatty acids and phospholipids to sustain mitochondrial and endoplasmic reticulum function and homeostasis. nature.com/articles/s42255-0…
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Updated preprint! Here, we identify an SREBP-dependent fatty acid sensing metabolic switch in Drosophila, enabling dramatic metabolic rewiring within adipose tissue that boosts carbohydrate metabolism in the absence of fat.
Read more here:
biorxiv.org/content/10.1101/…
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