1/ Spotlighting our former trainee @alexyema - a clinician-scientist specializing in IEI and cellular therapies @ UCL Great Ormond Street Institute of Child Health (GOSICH). She is also an Honorary Consultant in Paediatric Immunology at Great Ormond Street Hospital (GOSH), London

New human inborn error of immunity! By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.

New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50 #Immunology #Genetics #Atopy #IEIs

Fascinating and really cool 😎 study by @BogunovicLab in @jhumimmunity !

Earlier this month, the JMF team traveled to New Orleans for the Clinical Immunology Society (CIS) Annual Meeting, bringing together physicians, scientists, advocates, patients, and families from around the world to advance the future of clinical #immunology. During the meeting, JMF Scientific Director Jessica Quinn presented a poster highlighting findings from an upcoming publication on the Jeffrey’s Insights genetic sequencing program. We were proud to see our WINMD Grant recipients attending and presenting research posters at CIS. Supporting the next generation of researchers and innovators in immunology remains a vital part of JMF’s mission. While in New Orleans, we also hosted an in-person meeting of our Patient & Family Advisory Board (#PFAB), uniting patients and families affected by STAT1 GOF, STAT3 GOF, and JAK1 GOF to help create educational resources that truly reflect and amplify the patient experience. We are honored to continue supporting collaboration, research, education, and patient advocacy within the global PI community 💙 #CIS2026 #ClinicalImmunology #PrimaryImmunodeficiency #PICommunity #RareDisease #PatientAdvocacy #NOLA #JMFPFAB

Congrats Rui!! Terrific news. And totally deserved !

A major step forward for the Primary Immunodeficiency community 💙 The U.S. Food and Drug Administration has approved a new gene therapy for Wiskott-Aldrich syndrome – offering a potentially long-lasting treatment that uses a patient’s own cells to help restore immune function. For patients and families, this represents more than just scientific progress – it’s hope for safer, more effective care and a future with fewer infections and complications. Advances like this highlight the power of research, innovation, and advocacy in changing lives. Read the press release here: bit.ly/42cMqyH #PrimaryImmunodeficiency #PIAwareness #GeneTherapy #FDAApproval #Immunology #MedicalInnovation

Terrific work by @ErikaDellaMina1 identifying a novel pathogenic CARD9 variant, & identifying CD4 T cell defects that likely contribute to CMC in this and other CARD9 def patients.

Fantastic meeting and what a pleasure to spend time and learn from/with this fantastic group of friends! @ClinImmSoc @LASIDimmuno

Congratulations to Journal of Human Immunity Scientific Advisory Board member John J. O'Shea on his election to the American Academy of Arts and Sciences. We thank him for his leadership and dedication to the field of human #immunology. #HumanImmunity hubs.la/Q04dppS_0

1/ We returned to the @RockefellerUniv for the 33rd Annual Henry Kunkel Society meeting on “Autoantibodies Against Cytokines.” On Wednesday, our 2026 meeting organizer, @TrineMogensen kicked off the meeting with a warm welcome

This is a thorough, critical, and superb Review of a complex and controversial human B cell subset, the famous "ABC" -- a must-read !👇 Human CD21loT-bet B cells: Not as easy as “ABC”! rupress.org/jhi/article/2/4/…

New review from me in @jhumimmunity ! check it out!! trying to understand CD21lo (aka "atypical/exhausted/DN/age assoc'd") B cells! Human CD21loT-bet B cells: Not as easy as “ABC”! rupress.org/jhi/article/2/4/…

New review by @stutangye provides an overview of the discoveries, origins, and complexities of CD21ˡᵒ B cells, and how studying inborn errors of immunity can provide a unique window to understand the molecular requirements for generating these cells. hubs.la/Q04clJ340

1/ Spotlight on our former trainee Dusan Bogunovic (@BogunovicLab), a postdoctoral fellow in our NY lab from 2010-13 and now Professor of Pediatrics, Vice Chair for Basic Research, and Director of the Center for Genetic Errors of Immunity at @Columbia.

This is funny and true. :)

Important piece with a clear, cogent stance. It’s been challenging to convince some healthcare professionals that this is not a true inborn error of immunity.

I encourage anyone with an interest in human genetics, IEI, Mendel, monogenic disease, infection, mechanisms of disease - & scientific history - to download this review, get comfortable and have a good read!! A terrific perspective from JLC @casanova_lab in @jhumimmunity

Join us in congratulating our EiC Jean-Laurent Casanova on his 2026 Nemmers Prize in Medical Science! @casanova_lab discovered the genetic causes of more than 20 infections, including severe COVID pneumonia. From @NUFeinbergMed 👉 hubs.la/Q045TDS10

🎥 JHI’s Editor-in-Chief Jean-Laurent Casanova shares the vision behind JHI and what sets the journal apart in the rapidly evolving field of human immunity. Watch the full video and learn more about publishing in JHI here 👉 hubs.la/Q041StsR0