Excited to share our latest @Nature paper spearheaded by @YaelGruper identifying a new autoimmune disorder, characterized by impaired tooth development & generation of autoAbs against enamel matrix. It occurs in most AIRE def patients & ~1/3 of celiac kids nature.com/articles/s41586-0…

Here is the copy of the article @DrCatharineY!

The recorded video of Dr. Jakub Abramson seminar entitled Breath of fresh AIRE - From broken central tolerance to broken teeth and anti-fungal immunity is now available at “Global Immunotalks” YouTube Channel youtu.be/uVxcC6q5ewo?si=vv0O…  Hope you enjoy it! #globalimmuno #immunology

Happy to see our story on tolerance to inflammation antigens @NatImmunol nature.com/articles/s41590-0… It grew from a naive question I had at my first immunology class: if some self molecules are only induced by pathogen how does immune system distinguish them from foreign antigens?1/n

In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and led to a trial of ruxolitinib in five patients, who had dramatic responses. Read the full study results: nej.md/4bXoKkG

Congratulations to Prof. Jakub Abramson @TheAbramsonLab of the Immunology and Regenerative Biology Department and to Drs. @SegevEinat and @filipenatalio of the Plant and Environmental Sciences Department upon receiving the @ERC_Research 2023 Proof of Concept Grant #ERCPoC

The thymus can regenerate after acute injury due, in part, to the actions of local type 2 innate lymphoid cells (ILC2s), suggests a new study in mice. @WeizmannScience 📄: scim.ag/5wr

Very happy to share our latest ⁦@SciImmunology⁩ paper spearheaded by Shir Nevo uncovering the role of thymic fibroblasts and tuft cells in thymus regeneration upon acute injury science.org/doi/10.1126/scii…

Congratulations to @HonzaDobes87 for being awarded the FGS prize for outstanding achievements in postdoctoral research!

Thymus regeneration upon glucocorticoid-induced acute involution is orchestrated by IL-25– and IL-33–dependent activation of ILC2 @SciImmunology science.org/doi/10.1126/scii…

Could the consumption of milk lead to dental problems in some children? New research led by Prof. Jakub Abramson and his team has uncovered a new autoimmune disorder that affects the development of tooth enamel and is prevalent among children with celiac disease. While many people with celiac disease are not aware of their sensitivity to a protein abundant in processed dairy products, the research findings suggest that this same protein may trigger an autoimmune reaction that hinders proper tooth enamel development. These discoveries could facilitate early diagnosis in children and enable preventative treatment in the future >> bit.ly/NewAutoimmune-wis @TheAbramsonLab

Our @medrxivpreprint is open for public comment. We describe the experience of people reporting a chronic post-vaccination syndrome (PVS) after covid-19 vaccination. We are following the science. @VirusesImmunity @React19org @YaleMed @YaleCII medrxiv.org/content/10.1101/…

New paper out today in @jclinicalinvest! A new splice mutation of Aire that skips exon 7, shows a correlation between Aire function and degree of disease. Ex7splice retains some function, giving milder disease phenotype in compared to recessive variants jci.org/articles/view/169704…

In @JExpMed, @Brabec_Tomas_, @SchwarzerGnoto, @TheAbramsonLab, @FilippLab, @HonzaDobes87 et al. show that segmented filamentous bacteria induce the conversion of cognate CD4 T cells to cytotoxic intraepithelial lymphocytes. bit.ly/3tQJSbM @science_charles

We are very happy to share our lates publication in @Nature, spearheaded by Tal Givony &Yael Goldfarb, expanding the incredible cellular & functional diversity of mTECs and bringing key insights into the roles of thymic microfold and endocrine cells nature.com/articles/s41586-0…

Applications for the 2024-25 Azrieli Int’l #Postdoctoral #Fellowship are OPEN! Apply by Nov 15 to be considered for a postdoc position at a top academic institution in Israel – available to candidates worldwide. Learn more: bit.ly/3YSBmV7 #CallforApplications

NEW Review: The emerging family of RORγt antigen-presenting cells bit.ly/3OtuSbP by Greg Sonnenberg @TheAbramsonLab @MengzeLv @HonzaDobes87 summarizes the major findings that led to their discovery and discusses discordance in recent reports

dlvr.it/SsXgH8 I am very privileged to write this @NatRevImmunol review on RORγt APCs together with G Sonnenberg @MengzeLv @HonzaDobes87.  We review their history, molecular & functional complexity, while also highlighting existing unknowns and future perspectives

Congratulations to @CYImmunologists for organizing a fantastic mixer event and for kindly inviting me to be part of it. So happy to see Czech immunology blossoming again…

A well deserved break from the lab :) Had an incredible time together in the lowest place on earth 🌍 Thank you @IRB_Department for a great retreat!