Hubrecht Institute, Utrecht, The Netherlands
Joined September 2019
- Tweets 178
- Following 3
- Followers 5,032
- Likes 146
60 Photos and videos
The Clevers Lab retweeted
28 Dec 2025
Our countdown is never complete without a @TheCleversLab story! 😎
Their study of an in vitro model of mouse dorsal tongue epithelium holds 4th place in our countdown. 👏
If you missed the article in September, read it now. 👇
x.com/organoidscience/status…
30 Sep 2025
Dr. @HansClevers's team at @prinsesmaximac developed a protocol to generate a long-term expanding organoid model from the adult mouse dorsal anterior tongue. 👅
🧪 bit.ly/4nsXuRi
3
8
2,230
The Clevers Lab retweeted
24 Dec 2025
Using fluorescence real-time imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction.
With @TheCleversLab.
Great work by @NoordzijTomas & @CelottiMartina! @_Hubrecht
biorxiv.org/content/10.64898…
1
24
108
11,536
The Clevers Lab retweeted
11 Dec 2025
Daisong Wang and Sangho Lim describe human gut organoids with Peyer's patch M cells. M cells not only transport antigens: like professional antigen-presenting cells, they process and present gluten (the celiac disease antigen) directly to T cells rdcu.be/eT5s7
3
23
100
13,278
5 Sep 2025
1/4 Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. science.org/doi/10.1126/scie…
1
25
92
22,937
5 Sep 2025
3/4 This reveals a safeguard mechanism: epithelial cells constantly test each other’s mechanical strength. Too little (or too much) force destabilizes the barrier, linking extrusion to diseases like tufting enteropathy. Gut renewal is an active, force-regulated process.
1
1
12
1,146
5 Sep 2025
4/4 This work was a true team effort between @_amolf, @ihb_research, and the @_Hubrecht — led by @DanielKruegerDK and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.
18
2,846
12 Jun 2025
Do you want to learn how to make mouse thymus organoids?
Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue.
Read it here: doi.org/10.1016/j.xpro.2025.…
#Thymus #Organoids #STARProtocol #TEC
3
18
2,613
13 May 2025
Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025.
#ThymUS2025 #Organoids #Thymus
1
17
2,295
13 Feb 2025
Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: the-scientist.com/a-novel-th…
1
2
36
2,858
3 Dec 2024
📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here: sciencedirect.com/science/ar…
1
18
76
6,450
1 Nov 2024
Recent work from our lab explored the role of multiple nuclear receptors in the human small #intestine. Using #organoids and small molecules, we activated and then studied one nuclear receptor at the time through transcriptome characterization.
doi.org/10.1073/pnas.2411189…
1
20
99
12,500
17 Oct 2024
Watch back the 2024 EMBL Kafatos Lecture where @HansClevers presented about the application of organoids in disease modeling at the @_knaw Amsterdam. #embl #knaw #organoids youtube.com/watch?v=eePX-My4…
1
6
22
3,174
The Clevers Lab retweeted
2 Oct 2024
Exciting study! Organoid models reveal a novel role for human tuft cells in gut regeneration upon damage. Video: Tuft cell division is triggered by IL-4, visualized in human gut AVIL-Clover reporter organoids (Credit: Daniel Krueger) nature.com/articles/s41586-0…
5
72
376
27,333
1 Oct 2024
Our postdoc @TheodoreGrenier visiting the @ENSLyon to talk about his research on #IBD and #organoids.
8
1,442
23 Sep 2024
One bacterial protein as a complement to #Matrigel/#BME: The #integrin -binding domain of the Yersinia bacterial protein Invasin, coated as a single protein, maintains a defined long-term culture of various epithelial cells as “2D #organoid sheets”.
biorxiv.org/content/10.1101/…
14
46
3,953
10 Sep 2024
The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid
2
23
1,568
2 Aug 2024
Do you want to genetically engineer your organoids rapidly and accurately? Check out our recently published STAR Protocol about implementing Base and Prime Editors in organoids! A protocol developed by @CelottiMartina and @geurts_maarten
star-protocols.cell.com/prot…
16
86
6,034
The Clevers Lab retweeted
11 Mar 2024
Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! authors.elsevier.com/sd/arti….
2
10
28
4,770
The Clevers Lab retweeted
10 Mar 2024
British science giants, laid to rest in the north aisle of the nave of Westminster Abbey (also includes my feet...)
2
4
68
10,792