People who have spoken about nattokinase this year: - david sinclair - joe rogan - dr nick norwitz - dr. ferghal armstrong If you don't see a clear pattern emerging we don't know what to tell you, this little enzyme is finally getting it's day in the sun.

Dr. Ovadia says nattokinase is something he routinely recommends as part of his protocol for patients. It a fibrinolytic agent, meaning it helps the body break down blood clots as they start to form. He points to a trial showing reduced arterial plaque in patients taking it, though that study measured carotid (neck) plaque rather than coronary plaque, which he flags as a caveat. As mentioned below, the trial tested 3,600 units daily (not statistically significant) versus 10,800 units daily (significant plaque reduction), so he typically suggests around 10,000 units a day. He cautions that many supplements are dosed too low or poorly sourced, and that anyone on blood-thinning medication should talk to their doctor first. (h/t @KenDBerryMD & @DoctorTro)

David Sinclair says he’s been reversing plaque in his arteries with nattokinase. On Peter Diamandis’ podcast, Sinclair shared that he’s been taking it for years and mentioned a Chinese study with 1,086 people that showed up to 95% plaque reduction in one year at sufficient doses (at least 12 fibrinolytic units daily). He also checks his own carotid arteries with ultrasound and says there’s no buildup. Nattokinase is an enzyme from fermented soybeans that breaks down fibrin. Some human studies show it can help reduce arterial plaque and improve blood flow, but results vary. Larger, high-quality trials are still limited, so it’s considered promising but not definitive. Cardiovascular disease is still the #1 killer. If there are accessible tools that support artery health beyond statins and lifestyle, it’s worth paying attention. Have you heard about nattokinase or tried anything similar for heart health?

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Joe Rogan recently talked about a study involving 1,062 participants who took nattokinase for a full year. According to the reported ultrasound findings, arterial plaque was reduced by roughly 36%. The enzyme is said to help prevent new blockages while also supporting the reduction of existing plaque buildup. Here’s a closer look at the data and dosage protocol: (1/12)

Before you jump on the nattokinase train like what seems to everyone else it’s important you know how and why it works Nattokinase is a p-glycoprotein inhibitor P-gp is the body’s cellular "bouncer” and nattokinase temporarily disables it This means that compounds that would normally be pumped out are now free to pass through the cell and enter systemic circulation It allows target molecules to accumulate in higher concentrations inside the cells and tissues than they normally would How this can be a bad thing If you are taking a medication or supplement alongside a P-gp inhibitor, your liver and gut stop pumping the excess out When P-gp is inhibited, substances that have absolutely no business being in your central nervous system can cross the BBB and accumulate in the brain, leading to neurological side effects, lethargy, confusion, or neurotoxicity We don't just ingest pure nutrients and clean supplements, our food, water, and environment contain trace heavy metals, pesticides, plasticizers, and microbial toxins. Normally, if you ingest a trace environmental toxin, P-gp in your intestinal lining immediately recognizes it as a foreign threat and pumps it right back into the bowel to be excreted in stool. If P-gp is locked in the "off" position, your gut loses its ability to filter these out, allowing a much higher percentage of daily environmental toxins to pass directly into your systemic circulation and burden your liver and kidneys. By allowing molecules to bypass the initial gut defense and enter systemic circulation, you alter the kinetics of how your body processes everything. The burden shifts entirely to your phase I and phase II liver detoxification pathways and kidney filtration. If these downstream systems are already working hard, the sudden flood of highly bioavailable compounds can create a metabolic bottleneck Nattokinase is highly effective at preventing clots because it acts as a potent fibrinolytic enzyme, meaning it directly binds to and cleaves fibrin, the protein mesh that forms the structural backbone of a blood clot. Beyond directly dissolving existing clots, it simultaneously breaks down plasminogen activator inhibitor 1 (PAI-1), a compound that normally suppresses the body's natural clot-clearing mechanisms. By combining this direct clot-shredding action with the optimization of the body's intrinsic defenses, it significantly improves overall blood fluidity and circulation. Whether the risk is worth the reward depends entirely on what else is going into your body and your specific cardiovascular goals. For a completely clean, unmedicated protocol, maybe the risk profile is generally very low but the calculus changes completely the moment other pharmaceuticals or heavy supplement stacks are introduced. To run nattokinase in a safer way (if I were to take it) I would isolate its ingestion by taking it on an empty stomach at least two hours away from all other supplements, medications, or food. Ensure your protocol is completely free of pharmaceutical blood thinners or narrow-index cardiac medications to eliminate dangerous bioavailability spikes. And maintain a clean, low-toxin low vitamin A dietary baseline to minimize the systemic absorption of environmental impurities while the intestinal barrier's defenses are reduced.