News from the Laboratory of Cell and Membrane Biology (Gisou van der Goot Lab) at EPFL in Lausanne, Switzerland.
Joined July 2019
- Tweets 42
- Following 19
- Followers 149
- Likes 19
17 Photos and videos
Pinned Tweet
21 Nov 2023
Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence
nature.com/articles/s41467-0…
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10 Apr 2024
Late publicity! Check our last review regarding the wonderful world of S-#acylation aka #Palmitoylation. A comprehensive overview of the field and our take on the interplay between this #lipid #PTM and #immunity #metabolism #cancer and #brain. rdcu.be/dEk2w
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10 Apr 2024
A fantastic collaborative effort! Congrats to all involved! @FS_Mesquita @AbramiLaurence @MaurineLinder10 @ShernazBamji @chembioBryan and Gisou van der Goot!
@NatRevMCB
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VDG Lab @ EPFL retweeted
14 Feb 2024
Now Online Mechanisms and functions of protein S-acylation dlvr.it/T2l8H8
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VDG Lab @ EPFL retweeted
8 Jan 2024
💡Viewpoint💡
💫S-acylation: an orchestrator of the life cycle & function of membrane proteins💫
✍️By @FS_Mesquita, F. Gisou van der Goot et al from @EPFL_en
➡️buff.ly/3TJsBMF
#deacylation #ERassociateddegradation #palmitoylation #proteinturnover #Sacylation #OpenAccess
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21 Nov 2023
Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence
nature.com/articles/s41467-0…
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21 Nov 2023
Big thanks to all our collaborators and everyone from the @VDGLab @Trono_Lab @ACCESS_Unige. Learn more about the details of how cell damage caused by #viruses #toxins or #colitis regulates protein #acylation #palmitoylation, check it out!
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VDG Lab @ EPFL retweeted
27 Sep 2023
Delighted to share our take on the only reversible lipid PTM--S-acylation as a major regulator of protein dynamics and function and its implications in health and disease in @JCellBiol . @gvdgoot Thanks so much. Proud! Highlights in thread (1/7)
rupress.org/jcb/article/222/…
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VDG Lab @ EPFL retweeted
27 Sep 2023
Review: S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. @MUmairanwar1 and @gvdgoot @EPFL_en discuss the complexity and disease implications of this highly regulated reversible lipidation. bit.ly/3ta9gsE
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19 Apr 2023
#SARS2 #Lipidation Chapter2. How #SARSCoV2 boosts Host #Palmitoylation to promote infectivity! #Infection shifts transcription of ZDHHC20 palmitoyltransferase to increase #Spike Palmitoylation and produce more infectious #virus Stay tuned for Chapter3
biorxiv.org/content/10.1101/…
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19 Apr 2023
The N-terminal extension of ZDHHC20 prevents the protein from leaving the ER, extends its half-life, and enhances its #Spike modifying capacity by more than 35 times!
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19 Apr 2023
Finally, we show that #viruses produced by Long-ZDHHC20-expressing cells have enhanced infectivity. More details in the manuscript!
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VDG Lab @ EPFL retweeted
1 Nov 2022
Is there more than transcriptional programs to drive cell identity? Here with @GioeleLaManno we discuss the lipotype hypothesis nature.com/articles/s41580-0…
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VDG Lab @ EPFL retweeted
28 Sep 2022
ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains cell.com/developmental-cell/…
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VDG Lab @ EPFL retweeted
28 Sep 2022
This was really a nice journey … thank you @MUmairanwar1 , @oxyquips and @AbramiLaurence for taking us this far…
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VDG Lab @ EPFL retweeted
29 Sep 2022
Thanks to all involved, in particular @oxyquips @AbramiLaurence @gvdgoot @Gio_Dangel0.
@VDGLab we have to celebrate. 2/2
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VDG Lab @ EPFL retweeted
23 May 2022
How are membrane nanodomains formed? Delighted to share our preprint where we show that plasma membrane compartmentalization is controlled by rapid lipid composition remodeling at the ER-Golgi contact sites. (1/4)
biorxiv.org/content/10.1101/…
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7 Oct 2021
Our work is out! We are happy to share how #Palmitoylation controls #SARSCoV2 (#Covid19) #membrane #Cholesterol organization, and promotes #infection
cell.com/developmental-cell/…
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7 Oct 2021
Great team effort that characterizes the #viral #lipid composition and shows that host #lipidation is required for #SARS-CoV2 infectivity!
@Gio_Dangel0 @matteodp @labriataphd @Trono_Lab
@EnyaQing @FS_Mesquita @AbramiLaurence
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