@WackerLab profile picture
Daniel Wacker @WackerLab
Joined October 2017
  • Tweets 101
  • Following 98
  • Followers 458
2 Photos and videos
Our latest work: As it turns out different positive allosteric modulators bind to different sites at the mu opioid receptor. Find out more in our @biorxivpreprint. biorxiv.org/content/10.1101/…
7
14
1,733
A take on the current state of biased signaling in psychedelic action and psychedelic drug discovery by John McCorvy and I: Biased Signaling in Psychedelic Action | Annual Reviews - go.shr.lc/4lx1pLf

Biased Signaling in Psychedelic Action

Psychedelics show tremendous promise for treating psychiatric disorders and other illnesses, including pain and migraine. Despite decades of research, there is uncertainty which signaling mechanisms...

annualreviews.org
4
11
674
science.org/doi/10.1126/scia…

Structural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A

Structures reveal how a serotonin receptor binds different G proteins and how an antipsychotic selectively activates one pathway.

science.org
1
2
13
463
Job Alert! Open Postdoc position in membrane protein structural biology, molecular pharmacology @ drug discovery in New York. More info can be found here: wackerlab.com/
11
28
8,498
Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s41586-0… Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature

Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Nature - Detailed analyses of the serotonin receptor 5-HT1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling...

nature.com
7
32
88
10,108
Tetracyclic Antidepressants Activate Understudied Serotonin Receptors: science.org/doi/10.1126/scia… Congrats to @NeuroStruct, @Allyparp, and Audrey Warren for their study in @ScienceAdvances with help from @martafilizola, @NCCATinfo, and @GradSchoolSinai!

Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin...

Tetracyclic antidepressants unexpectedly activate understudied serotonin receptors, which may explain their antimigraine effects.

science.org
1
6
21
2,610
Typo on my end: The study was spearheaded by @NeuroStructure
3
431
Asenapine as a potent TAAR1 agonist nature.com/articles/s41467-0… Congrats @NeuroStructure

Molecular basis of human trace amine-associated receptor 1 activation

Nature Communications - hTA1 is a drug target for several neuropsychiatric disorders. Using cryo-EM and pharmacological assays, the authors illuminate hTA1’s similarity to neurotransmitter...

nature.com
5
11
39
3,617
Tetracyclic antidepressants potently activate serotonin receptors 5-HT1e and 5-HT1F, explaining some of their clinically observed effects. @NeuroStructure @martafilizola @biorxivpreprint @biorxiv_neursci biorxiv.org/content/10.1101/…

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin...

Serotonin (5-hydroxytryptamine, 5-HT) acts via 13 different receptors in humans. Of these receptor subtypes, all but 5-HT1eR have confirmed roles in native tissue and are validated drug targets....

biorxiv.org
8
31
4,114
Also, here is our @biorxivpreprint on the structure and pharmacological properties of human TAAR1 biorxiv.org/content/10.1101/…

Molecular Basis of Human Trace Amine-Associated Receptor 1 Activation

The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its...

biorxiv.org
3
16
1,262
Structural Studies and Drug Discovery of SLC4A1/AE1 with @SchlessingerLab published in @NatureSMB: nature.com/articles/s41594-0…

8
11
51
8,958
Also, the lab is looking for a Postdoc conducting the type of research described in the paper: CryoEM, membrane protein function and pharmacology, drug discovery.
2
7
1,127
Sharing our @bioRxivpreprint of “Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter”, in which we reveal how AE1 binds and transports substrates, and how different drugs inhibit the transporter.
3
19
76
Thanks to first author @CapperMichael and collaborators including @SchlessingerLab, we report 7 structures, uptake and computational assays. Our mechanistic work complements the beautiful AE1-erythrocyte complex architecture reported by @OliBClarke. biorxiv.org/content/10.1101/…

Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter

Anion Exchanger 1 (AE1, SLC4A1) is the primary bicarbonate (HCO3-) transporter expressed in erythrocyte membranes where it mediates transport of CO2 between lungs and other tissues via import/export...

biorxiv.org
6
25
Daniel Wacker retweeted
Marta Filizola@martafilizola
27 Oct 2019
Peer-reviewed version of ⁦@filizolalab1⁩’s ‘Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation’ is now available on @biophysJ - ScienceDirect sciencedirect.com/science/ar…

1
15
40
Daniel Wacker retweeted
Friedman Brain Institute@SinaiBrain
1 Oct 2019
EXCITING NEWS! Dr. Denise J. Cai receives prestigious @NIH Director’s New Innovator Award from the @NIH_CommonFund’s High-Risk, High-Reward Research program! A HUGE CONGRATULATIONS to @denisejcai on this great honor!🍾🎉🌟 PRESS RELEASE: ow.ly/tO5y50wycTn
7
13
70
I am currently looking for a motivated Postdoc to join our team to work on the structure and function of neurotransmitter receptors and transporters. Spread the word! More info on our lab webpage wackerlab.com
14
25
Daniel Wacker retweeted
Patrick Giguere@TheGiguerelab
5 Jun 2019
Graduate student position available in my lab for highly motivated student!
1
11
10
Daniel Wacker retweeted
Cell@CellCellPress
4 Jul 2019
Online now at Cell: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells zpr.io/gJjGU
19
56
Congratulations to my former colleague Justin English for his new paper in cell cell.com/cell/fulltext/S0092…

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells

The VEGAS system is a platform for directed evolution, a method for engineering DNA sequences, in mammalian cells. The system is highly mutagenic, facile, and self-contained, requiring no in vitro...

cell.com
1
2
16
Now someone give @JustinGEnglish a real job already!
1
6
Load more