Biotech. Interests: oncology, transcription factors, RNA, biomolecular condensates, RNA-binding proteins, neurodegeneration, aggregation, disordered proteins
Joined August 2015
- Tweets 18,043
- Following 5,408
- Followers 4,925
- Likes 16,371
460 Photos and videos
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Bede Portz retweeted
Jun 11
Our TEAD1 condensate paper is now online at Nature Cell Biology! TEAD1, despite being a transcription factor, forms condensates at the heterochromatin. We found that it actually served as depots to sequester excess TEAD1. Nature is full of surprises!
nature.com/articles/s41556-0…
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Bede Portz retweeted
Jun 11
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
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Bede Portz retweeted
At Tahoe, one of the reasons we are excited about perturbation prediction is to ultimately predict how patient samples will respond to any of the many drugs in our library
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Bede Portz retweeted
Jun 9
Today we release Rhaister, an elegant statistical model that predicts drug phenotypes in new contexts w/ accuracies comparable to experimental assays.
And dropping Emerald Bay, a 2M cell dataset measuring long time-course phenotypes across 1000s of drug-cell line interactions.
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Bede Portz retweeted
Excited to share the first pre-print from our lab!!
Check it out here! biorxiv.org/content/10.64898…
We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
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Jun 8
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Deep learning of functional perturbations from condensate morphology: Cell cell.com/cell/fulltext/S0092…
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Bede Portz retweeted
Jun 4
Deep learning of functional perturbations from condensate morphology: Cell cell.com/cell/fulltext/S0092…
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Bede Portz retweeted
Jun 6
I believe this next wave of Bio is going to be bigger than anyone can imagine.
Multiple $10T companies. Maybe even a 100 Trillion dollar company.
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Jun 6
Came across this really cool compendium of AI foundation models in life sciences curated by @neuromusic and had to share. bio.rodeo/
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Bede Portz retweeted
If there are big funders out there, would strongly recommend funding large scale data generation efforts with @fordycelab . They have incredible next generation tech to push the frontier on protein function.
Jun 3
Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)
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Bede Portz retweeted
May 31
Great interview & detailed explanation of going from a basic/foundational biological technology platform & pulling in some already established chemistry whose potential is highlighted by the platform, to accelerate into the clinic. $EIKN @EikonTX @bradloncar
May 31
𝐀𝐒𝐂𝐎 𝟐𝟎𝟐𝟔: Fresh off an IPO, @EikonTX's Chairman & CEO Roger Perlmutter describes the scientific idea behind the company, and walks us through the leading programs. $EIKN #ASCO26
Full video: biotechtv.com/post/eikon-the…
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Bede Portz retweeted
Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins
Effects of residue substitutions on the cellular abundance of proteins
doi.org/10.7554/eLife.103721…
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Bede Portz retweeted
May 28
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Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
biorxiv.org/content/10.64898…
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Bede Portz retweeted
May 26
ft. Katie Copley, Ashleigh Smirnov, Leland Mayne, @M_Linsenmeier, @JackRubien, @YSPTSPS, Bo Lim Lee, Hana Odeh, Longsheng Lai, @yiweichang Ben Black & @ShorterLab (@BB_UPenn) @ScienceMagazine science.org/doi/10.1126/scie…
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Bede Portz retweeted
May 26
Excited to share our collaborative work with the @TonyMustoe and @SuperSciJew labs, led by the fearless @RitwikaBose15.
In this study, we developed RAID-MAP, an approach to map RNA structure within biomolecular condensates in living cells.
biorxiv.org/content/10.64898…
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Bede Portz retweeted
May 25
Published a piece outlining our approaches at OpenADMET where we are trying to build the CASP for small molecule ADMET prediction w/ @fraser_lab @BioSteve @lnhandly @jchodera @Mark_Murcko @wpwalters
nature.com/articles/s41467-0…
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Bede Portz retweeted
May 21
Cool new video the Breakthrough Prize team put together featuring Tony @HymanLab and I describing the excitement and adventure of our discovery!
youtube.com/watch?v=3Exd2kcV…
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