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Yeeles Lab @Yeeles_Lab

We’re a lab based at @MRC_LMB in Cambridge using biochemistry and structural biology to understand how DNA replication works 🧬

Joined July 2022
  • Tweets 26
  • Following 179
  • Followers 845
Photos and videos
Yeeles Lab retweeted
Tom Deegan@TDDeego
5 Nov 2024
Great first day of EMBL DNA replication meeting in beautiful Heidelberg, including a hike to the Schloss with @Yeeles_Lab
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Yeeles Lab@Yeeles_Lab
10 Oct 2024
Amazing talk from @JohannJRoske at the #LMB lab talks! Thanks to @this_clockwork for bringing the replisome to life 🧬🧬🧬
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Yeeles Lab retweeted
Harry Orrin@HarryOrrin
10 Sep 2024
Excited for the first day of the UK DNA Replication Meeting 2024! First up: all things initiation. @BiochemSoc #BiochemEvent
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🚨📣 Excited to share our latest work investigating how the replisome responds to topoisomerase-DNA crosslinks 🧬🔬 cell.com/molecular-cell/full… Fantastic work from @rosewesthorpe and @JohannJRoske 🍄🍄🍄🍄

Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes

Using biochemical and structural approaches, Westhorpe et al. have characterized the response of the core DNA replication machinery to topoisomerase 1-DNA crosslinks. This work reveals that the...

cell.com
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We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬 Read @NatureSMB nature.com/articles/s41594-0…
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Yeeles Lab retweeted
Clockwork@this_clockwork
5 Aug 2024
Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels I used this to make my latest video: (youtu.be/lv89fSt5jBY) But now I want to do a quick works cited 🧵 (1/ ?)
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Yeeles Lab retweeted
Tom Deegan@TDDeego
23 Jul 2024
New paper from my group, in which we use the combined power of AlphaFold and biochemical reconstitution to determine how the Rrm3 helicase is targetted to the eukaryotic replisome embopress.org/doi/epdf/10.10…

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Yeeles Lab@Yeeles_Lab
23 Jul 2024
Brilliant to see our talented postdoc, Cristian, publish his work on CMG disassembly in @embojournal. The culmination of his PhD work in the Labib lab at @dundeeuni. @TDDeego embopress.org/doi/full/10.10…..

CMG helicase disassembly is essential and driven by two pathways in budding yeast

The EMBO Journal - The CMG helicase is the stable core of the eukaryotic replisome and is ubiquitylated and disassembled during DNA replication termination. Fungi and animals use different enzymes...

link.springer.com
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Yeeles Lab retweeted
Tom Deegan@TDDeego
19 Dec 2023
Join us next year for the 2nd edition of the UK DNA replication meeting in Cambridge. The first meeting was fantastic so be sure not to miss out! @Yeeles_Lab @AgaGambus @saponaro_m eventsforce.net/biochemsoc/f…

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Happy 30th Birthday to one of our favourite structural biologists @mljones1993 🥳🥳
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Having fun at Cold Spring Harbor! @mljones1993 #cshldnarep #renaissanceman #howdoyoueatlobster
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So excited to have arrived at @cshlmeetings Eukaryotic DNA Replication and Genome Maintenance!! Can’t wait to hear all of the amazing science and catch up with old and new friends 🧬 #cshl
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Yeeles Lab retweeted
John Diffley@DiffleyLab
24 Aug 2023
Hi all. Two fully funded four year postdoc positions to study DNA replication initiation using human proteins. Please check out the ad and contact me if you want more info. Closing 30 September. crick.ac.uk/careers-study/va… crick.ac.uk/careers-study/va…

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Yeeles Lab retweeted
Molecular Cell@MolecularCell
27 Jul 2023
Online Now: How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication dlvr.it/Ssq3qW

How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication

By determining cryo-EM structures of budding yeast and human replisomes containing the Pol α-primase complex, Jones et al. reveal a conserved mechanism for the coordination of nascent-strand priming...

cell.com
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Yeeles Lab@Yeeles_Lab
27 Jul 2023
Very happy and excited to share our latest work on Pol α-primase recruitment to the eukaryotic replisome! 🧬 ⬇️ #dnareplication #cryoEM #biochemistry
Morgan Jones@mljones1993
27 Jul 2023
🔬📚 Very excited to share our new paper titled "How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication"! 🧬 A #tweetorial below ⬇️ @MolecularCell @Yeeles_lab #ScienceTwitter #cryoEM #replication #DNA #polymerase #primase #MolecularBiology #replisome
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Yeeles Lab retweeted
Patrycja Kozik@patrycja_kozik
23 Jun 2023
Our work on perforin-2, a pore-forming protein expressed by #DendriticCells to deliver antigens into the cytosol during #CrossPresentation is now out in @ScienceMagazine science.org/doi/10.1126/scie…… Huge amount of work from Pablo, in collaboration with @laub_marco & @Pati_Krawczyk
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Come along to extract DNA from bananas with the Yeeles lab!
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Yeeles Lab retweeted
Zha Lab@zha_lab
16 Oct 2022
Our best wish to the continued success of our rising stars. Can not wait to hear more in the future! Dr. Joe Yeeles @Yeeles_Lab will tell us how his lab successfully reconstitutes the human replisome! Wow! Sign up at cancer.columbia.edu/research…
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