Graduated but still working on my thesis project… • NCSU ‘17 • JHU ‘19 • UPenn ‘24
Joined February 2020
- Tweets 207
- Following 206
- Followers 174
- Likes 1,051
5 Photos and videos
Ruchi Patel retweeted
Apr 13
Excited to share that my second paper from graduate school is out now at Nature Genetics. We show that Enhancer-Promoter interactions can form de novo in the absence of loop extrusion.
nature.com/articles/s41588-0…
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Ruchi Patel retweeted
24 Feb 2025
Exciting news: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models @Cancer_Cell @MarcoRuella @AlbertoCarturan @PuneethGuru_ @_ruchipatel @yunlin_zhang_ @guido_ghilardi and my stellar co-author Siena Nason
cell.com/cancer-cell/abstrac…
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Ruchi Patel retweeted
13 Jan 2025
Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.1101/…
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Ruchi Patel retweeted
24 Dec 2024
cell.com/molecular-cell/full…
Our paper is now online @MolecularCell. Architectural protein LDB1 drives enhancer connectivity independently of CTCF/cohesin!
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Ruchi Patel retweeted
10 Dec 2024
Wild experience to have seen our story shared at the #ASH24 Plenary in San Diego by my wonderful co-lead @Shan_Liu_ ! Looking forward to further proving that we can enhance cancer treatment by modulating readily-actionable patient lifestyle factors.
8 Dec 2024
A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_ spr.ly/6015QKswz
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Ruchi Patel retweeted
8 Dec 2024
Grateful to #ASH2024 for the chance to present our work on overcoming the absence of CD2:CD58 co-stimulation using an innovative PD1:iCD2 switch receptor. Thanks to my mentor @MarcoRuella and the @RuellaLab for their invaluable support. Excited to delve deeper into this approach!
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Ruchi Patel retweeted
3 Dec 2024
Learn more about the exciting advances in blood cancer and benign hematology research that Penn Medicine and @PennCancer experts will be presenting at the @ASH_hematology Annual Meeting this weekend. #ASH24 spr.ly/6015txypB
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Ruchi Patel retweeted
5 Dec 2024
#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine
ash.confex.com/ash/2024/webp…
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Ruchi Patel retweeted
8 Dec 2024
A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_ spr.ly/6015QKswz
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27 Nov 2024
Looking forward to discussing our latest work on CD5 next week! Register here to join: workcast.com/register?cpak=2…
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Ruchi Patel retweeted
3 Sep 2024
Very excited to share this work that could not have been done without the help of @RaisBahrami and @arnabguonc ! Big thank you to The Oncologist for this opportunity!
3 Sep 2024
High-sensitivity #ctDNA tests can be used to detect radiologically occult disease or minimal residual disease post-surgery & identify high-risk patients. This review summarizes current evidence, w/ focus on genitourinary tumors. @KartikPatel___
doi.org/10.1093/oncolo/oyae1…
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Ruchi Patel retweeted
25 Aug 2024
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin!
biorxiv.org/content/10.1101/…
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Ruchi Patel retweeted
5 Aug 2024
The effectiveness of #CARTCellTherapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, according to research led by @PennCancer's Dr. @MarcoRuella. spr.ly/6012YGdWi
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Ruchi Patel retweeted
2 Aug 2024
In a study published in @SciImmunology, @PennMedicine researchers identify #CD5 as an immune checkpoint protein & potential target of future cancer therapies ft. @MarcoRuella (@PennCancer) tinyurl.com/4nzzy3bs
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Ruchi Patel retweeted
26 Jul 2024
A discovery from PICI Investigators @Penn has revealed that deleting the CD5 gene in CAR T cells significantly enhances their antitumor activity across multiple cancer types, opening new avenues for more potent and effective immunotherapies. science.org/doi/10.1126/scii… (5/5)
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Patel et al. used the CRISPR-Cas9 system to ablate expression of the TCR-associated T cell inhibitory receptor CD5 from CAR T cells of several specificities and TCR-redirected T cells. bit.ly/4cnT9J7 @_ruchipatel @MarcoRuella @PennMedicine
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30 Jul 2024
Looking forward to joining @pillar_vc Frequency Bio's Cohort 10 next week! Excited to learn more about the biotech startup community.
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Ruchi Patel retweeted
23 Jul 2024
Genetic deletion of #CD5 in CAR T cells given to mice led to enhanced expansion, persistence, and anti-tumor effects against a range of preclinical solid and blood #cancer models.
Read more in Science #Immunology: scim.ag/7LE
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Ruchi Patel retweeted
23 Jul 2024
NEW -CD5 deletion enhances the antitumor activity of adoptive T cell therapies in vivo (liquid & solid cancer models) by enhancement of T signaling, cytotoxicity, and persistence. Stellar work by @_ruchipatel @MarcoRuella @PennMedicine @SciImmunology science.org/doi/10.1126/scii…
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Ruchi Patel retweeted
22 Jul 2024
A @PennCancer research team led by @MarcoRuella has found that CD5 knockout boosts #CARTcell anti-tumor efficacy, in a preclinical study published in @SciImmunology. spr.ly/6013ihrxL
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