.@coeff_giving directed over $1b in 2025, the most in our history.
I wrote a more personal annual letter this year, focusing on what a decade of grantmaking has taught me, how I'm thinking about AI, and how we're grappling with giving at this scale. đź§µ
Catching up on my Clinical Trials Abundance reading! Fascinating story from @RuxandraTeslo about the FDA unnecessarily tightening standards on CAR-T cancer therapies and almost derailing their commercialization clinicaltrialsabundance.blog…
A summary of the findings from our first release of the Canaries Dashboard.
1: Across workers of all ages, there is not large divergence in employment by a traditional measure of AI exposure (Eloundou et al.), But the most exposed group might be lagging slightly behind.
Is AI impacting early-career employment more than mid-career? And do we see a large contrast between the most- and least-AI exposed occupations? The Canaries Dashboard, a collaboration between ADP Research and the Lab, is available now. canaries.stanford.edu
New post!
@NikoMcCarty and I have been writing regular round ups for a little while now, but so much has happened recently that this month’s What's New in Biology post feels like it contains a year’s worth of breakthroughs.
worksinprogress.news/p/whats…
The most effective weight-loss drug so far, cancer breakthroughs, gene editing for cholesterol, ancestral CRISPR systems, a cure for some with hepatitis B, the first PROTAC drug, and more.
Read it here!
Thrilled to share that 10k new units benefited from AB 130, making it one of the most effective streamlining laws on the books.
July 2025 to May 2026:
· Total Projects: 68
· Total Housing Units: 10,378
· Affordable Units: 1,077 (10.38%)
· Market-Rate Units: 9,301 (89.62%)
/6
ALT Screenshot of a map of California showing where the lead agencies of AB 130 projects are located. Pink pinpoints span the map from Mendocino in the north to San Diego in the south. Most pins are clustered around the Bay Area and Los Angeles area.
ALT Screenshot of a map of the Bay Area in California showing where the lead agencies of AB 130 projects are located. Pink pinpoints show that many projects are clustered in this area, including San Jose, Hayward, Richmond, and San Rafael.
ALT Screenshot of a map of the Los Angeles in California showing where the lead agencies of AB 130 projects are located. Pink pinpoints show that many projects are clustered in this area, including Los Angeles, Glendale, Long Beach, Torrance, and Mission Viejo.
We have a new paper in @ScienceMagazine today on the air quality benefits of expanded use of prescribed fire, capably led by @ivanhigueram. Rx fire can lead to substantial net reductions in smoke, but effects will take years to be realized. Link/ deep dive in thread below
And then some good news: Baltimore's incredible decline in homicides was driven by intervening early with those at risk of committing a violent crime. Although that idea wasn't new, dedicated execution made the difference. nber.org/papers/w35292
Join my team! We’re looking for Senior *Cross-Cutting* Researchers to make sure we maintain research quality as GiveWell scales our grantmaking over the next few years 🧵
Very interesting post by @kroetscha about how little (adoption of) innovation there is in clinical trials in part due to risk aversion and steps the FDA could take to encourage best practices. Effects on costs could be surprisingly large! open.substack.com/pub/learni…
Malaria kills ~600,000 people a year.
GiveWell has directed $1B to malaria prevention—with our growing research team, we're expanding the work: funding new studies, increasing core program coverage, & exploring other prevention strategies.
Read more ⬇️ bit.ly/4apLgo4
To celebrate the debut of the @IFP@UChi_MSA Atlas of Innovation, a guide to funding innovation, a thread of my favorite Atlas illustrations (by R. Kikuo Johnson)!
First: “milestone payments” - get it?
(Atlas explainer: abundanceandgrowth.org/p/an-…)
NEW: Anthropic is walking back Claude Fable 5's policy to covertly degrade performance for competing AI researchers, after facing fierce backlash.
“We’re changing Fable 5’s safeguards for frontier LLM development to make them visible,” Anthropic tells WIRED. “We made the wrong tradeoff and we apologize for not getting the balance right.”
The ugly: The CFTC ties themselves in further knots to explain how an entity may have exposure on number of points a player scores in a game. These types of bets are gambling. If a state wants to legalize sports betting, fine. But they are not commodity markets under CFTC.
3/3
Today, the Stanford @DigEconLab launches the AI Economic Indicators, a new platform for tracking how AI is reshaping work, productivity, adoption, and the economy.
1/6
We are starting a new, nonprofit alignment organization, ⊢ Sequent Research, bringing together researchers previously on UK AISI’s Alignment Team, Timaeus, and elsewhere to research how to align superintelligence. We are hiring! 🧵
Does cleaning up drinking water save lives?
New paper: We link US federal drinking water investments to Medicare records and find they reduce mortality among older Americans, with benefit/cost ratio >20.
Thread on what we did...
w/ @DavidKeiserEcon Mazumder @_josephshapiro