Joined August 2009
- Tweets 77
- Following 3,400
- Followers 295
- Likes 2,383
Photos and videos
Nader retweeted
Mar 20
1/7 First of all, big shoutout to co-authors on modeling (@MKarimzade, @neal_ravindra, @RexMa9, @HAOTIANCUI1, @LeeTaliq), huge appreciation to data generation (Lexi, @alerasool, Adam) and bioinformatics team (@_annhuang), and leadership for vision and direction (@BoWang87, @inCiChu)!
Preprint is now live on bioRxiv: biorxiv.org/content/10.64898…
All models start from high-quality data.
Our X-cell is up at @biorxiv_bioinfo !
Read our full paper at biorxiv.org/content/10.64898…
Part of the data and the model weights will be shared soon. stay tuned!
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Nader retweeted
1 Oct 2024
Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/S0092…
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Nader retweeted
26 Jun 2024
Our latest work on developing a potent and specific tool for activating or repressing endogenous splicing events is out! authors.elsevier.com/c/1jJci…
24 Jun 2024
Graduate student Jack Li's work out in Molecular Cell now: By conducting a screen of 341 splicing factors, Jack identified RBM25 coupled to dCasRx as a superior tool to boost inclusion of endogenous exons /1
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Nader retweeted
24 Jun 2024
Graduate student Jack Li's work out in Molecular Cell now: By conducting a screen of 341 splicing factors, Jack identified RBM25 coupled to dCasRx as a superior tool to boost inclusion of endogenous exons /1
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Nader retweeted
24 Jun 2024
Check out our CRISPR genome-scale exon perturbation study @MolecularCell. We identified exons influencing cell fitness and uncovered a novel mechanism by which #splicing affects #transcription. @Michael_Aregger @dlarun88 @meisheng_xiao @NCIResearchCtr @NIH
doi.org/10.1016/j.molcel.202…
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Nader retweeted
20 Mar 2024
Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s41586-0… rdcu.be/dBUju
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Nader retweeted
1 Mar 2024
early winter @newlimit:
- >10X more reprogramming factor sets tested than ever before
- >2M cells profiled, 10TB of raw seq data
- 3 team members
- 2X speed up in reprogramming library build times
- 1 cell types on our Engine
- 1st rejuvenating hits
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Nader retweeted
22 Jan 2024
📜 Happy to share our recent preprint featuring ORFtag - a versatile, easy and cost-effective method for probing protein function at a proteome scale. This work is the result of a collaborative effort by the @stark_lab, @AmeresSL, @EllingUlrich and @juliusbrennecke labs. 1/2
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Nader retweeted
9 Jan 2024
2023 @newlimit:
- 50X more reprogramming factor sets tested than the field before us
- 20X factor demultiplexing performance (reading), 7X factor delivery (writing)
- 2X team size
- 3 functional assays for immunology program
- 2 in silico model metrics > SOTA
blog ⬇️
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Nader retweeted
4 Dec 2023
Induxion is looking for a Research Associate/Technician to support its platform activities - Located in Toronto. jobrxiv.org/job/induxion-the…
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Nader retweeted
13 Nov 2023
early autumn @newlimit:
- 6X'd the # of reprogramming factors we've tested
- >4X'd signal-to-noise for our core pooled screening assay
- shortened feedback cycles by 40%
- improved in silico reprog models >30%
all covered in our latest blog
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Nader retweeted
7 Sep 2023
Our latest preprint is out! In a fun collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/8
biorxiv.org/content/10.1101/…
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Nader retweeted
12 Jun 2023
Ever wondered if you could read 100s of metabolites and drugs in parallel using a @illumina or a @10X platform? But metabolites aren’t nucleic acids — how can that work? Check out our new preprint and read on for a thread:
biorxiv.org/content/10.1101/….
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We're excited to announce that we've raised our Series A from @_DimensionCap, @foundersfund, & @kleinerperkins
blog.newlimit.com/p/newlimit…
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Nader retweeted
15 May 2023
New preprint! 🗞️ We used pooled protein screens to develop compact human transcriptional effectors that work across diverse biological contexts to activate or silence gene expression
biorxiv.org/content/10.1101/…
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Nader retweeted
5 May 2023
last month @newlimit:
- 1st reprogramming screens in primary cells
- Immunology team 3X'd
- 1st model-driven hypotheses
this month:
- improving screen efficiency: more exps/{$, time}
- multi-modal in silico reprogramming models
all this & more in our April update ⬇️
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Nader retweeted
20 Mar 2023
Our paper on 14-3-3 proteins and their role in protein aggregation and phase separation is out! This paper represents the main PhD thesis work by my student Dmitri Segal. 1/ cell.com/molecular-cell/full…
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Nader retweeted
14 Mar 2023
last month @newlimit:
- largest partial reprogramming screen yet
- 50% more TFs to test
- first in silico reprogramming models
this month:
- screens in old donor cells
- library rebuild -- 10X manufacturing efficiency
- automating screen analysis to shorten DBTL loops
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Nader retweeted
26 Jan 2023
A universal deep-learning model for zinc finger design enables transcription factor reprogramming go.nature.com/3HBtUH5
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