Selpercatinib in RET Fusion–Positive Non–Small Cell Lung Cancer
#NSCLC 🫁 : Final Safety and Efficacy, Including Overall Survival, From the LIBRETTO-001 Phase I/II Trial
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This phase I/II study evaluating selpercatinib in RET fusion-positive non–small cell
#Lungancer (NSCLC) saw Final results with durable efficacy, an objective response rate (ORR) of 62% in patients who had prior platinum-based chemotherapy and 83% in treatment-naïve patients. The duration of response (DoR) was 31.6 months and 20.3 months, respectively, and progression-free survival (PFS) was 26.2 months for pretreated and 22.0 months for treatment-naïve patients. At 3 years, 57% of pretreated and 66% of treatment-naïve patients were alive. Selpercatinib also demonstrated an 85% ORR in patients with CNS metastases.
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