I’ll be giving an oral talk on this TenK10K multiome project at #ESHG2026 at 11:45am, Jun 14 in Room F1-3 (session C17.6). Join me if you’re interested in caQTL/eQTL mapping, GWAS "missing regulation", multiomics integration & our TenK10K cohort! Happy to chat 1-on-1, plz DM me.

This new paper is probably the most prominent example to date of how linking genetic variation to cell-level, rather than tissue-level, gene expression can transform the interpretation of GWAS signals. The study generates a single-cell eQTL resource from intestinal biopsies and blood samples from 421 individuals, including 125 with inflammatory bowel disease (IBD)👇

🧬New from Yazar et al! 📄The impact of sex on the immune system explored at the single-cell level cell.com/ajhg/fulltext/S0002…

SMR just got a major efficiency upgrade.⚡️Check out the new release here: yanglab.westlake.edu.cn/soft…

Announcing "Fast Biology Bounties." I'm giving away $10,000 for ideas to speed up or reduce costs for wet-lab experiments. I'm looking for ideas that are highly original and technically tractable. A couple paragraphs will suffice. Supported by Astera Institute. Details below.

Join us at Cell Symposia: Single-Cell Biology in the Era of AI (Dec 2–4, 2026, Munich) 🇩🇪 From multi-omics to AI-driven models of cellular dynamics — an exciting lineup across experimental & computational biology. Hope to see you there! 🔗 cell-symposia.com/single-cel…

Human pluripotent stem cells allow scientists to model human tissues and organs without using animals, but labeling cell types and states accurately can be tricky. In this perspective, @twatkeson and colleagues propose a “stem cell-relevant manifold”—a large reference map combining human tissue and stem cell-derived data. This could improve cell annotation, make lab-grown cells more physiologically accurate, and speed insights into development, disease, and potential therapies. Read in @stemcellreports: cell.com/stem-cell-reports/f… 👥 @Elias_RuizMor, @roserventotormo, @drneavin, @drjosephpowell, et al. 🏛️ @GarvanInstitute, @reNEW_Global, @sangerinstitute, @SCICambridge, @CellularFutures 💰 @nhmrc, @reNEW_Global, @wellcometrust

Amplifying for Trainees attending #ASHG25

A new, tour de force review on the future approaches to treat and potentially cure Type 1 diabetes @TheLancet thelancet.com/journals/lance…

⭐ Congratulations to Dr Albert Henry from Prof Joseph Powell’s lab on being awarded the NSW Health Cardiovascular Research Elite Postdoctoral Researcher Grant. His work combines data science with cardiovascular genetics to identify new therapeutic targets for heart disease.

Did a brief interview with @FLGenomics on sctrends.org and our views on what works in single-cell/spatial 'omics! Write up here: hubs.la/Q03qCBPQ0

📢 Up to 10 fully funded PhD scholarships at Human Technopole through @semm_it ! Join our international community & do cutting-edge research in Systems Medicine. Apply by 9 June 👉 humantechnopole.it/en/news/1… #phdlife #phdcareers

Please check out our new manuscript extending the GREML methodology to quantify assortative mating and other forms of trait-associated genetic structures. Thanks to all our co-authors and the study participants! Here: nature.com/articles/s41588-0…

Oz Single Cell Conference is here & we have much to talk about - @ST_Omics – High-res spatial transcriptomics @MGI_Technology – Sequencing for precision diagnostics @ParseBio – High-throughput single-cell profiling #Genomics #SingleCell #OzSingleCell #EnablingDiscovery

Check out our scPrediXcan paper cell.com/cell-genomics/fullt… Led by talented @Charles_Zhou12, supervised by @MengjieChen6 and me, with thanks to many contributors scPrediXcan integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework.

Heading to Oz Single Cell Sydney @ozsinglecells? Meet Element Biosciences & explore AVITI24™, the first intelligent #multiomics platform. Don’t miss Matthew Kellinger, PhD presentation: "High Dimensional Biology: #SingleCell & Spatial Multiomics Powered by #AVITI24". bit.ly/4m6OZLs #ozsinglecell25

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply below. Please repost!

Reminder: Early bird registration closes tomorrow! eventbrite.com.au/e/oz-singl…

🚨 Our latest GWAS of heart failure subtypes is now out in Nature Genetics! rdcu.be/eb9O0 A massive global collaboration from HERMES Consortium involving >40 studies with >150,000 heart failure cases. @HERMESgenetics @tomlumbers 🧵 highlighting key findings 1/

Dig further into #gwas data on the NEW Open Targets platform! Congrats to the @OpenTargets team on the new release!