In cisplatin-ineligible patients with muscle-invasive bladder cancer, enfortumab vedotin–pembrolizumab plus surgery led to better event-free survival (74.7%, vs. 39.4%) and overall survival (79.7%, vs. 63.1%) than surgery alone at 2 years. Full phase 3 KEYNOTE-905 trial results and Research Summary:
nejm.org/doi/full/10.1056/NE…
ALT The New England Journal of Medicine
Perioperative Enfortumab Vedotin–Pembrolizumab in Bladder Cancer
A Research Summary based on Vulsteke C et al. | 10.1056/NEJMoa2511674 | Published on February 18, 2026
Visual representations of the patients in the trial and the treatments they were assigned.
Read the full Research Summary at NEJM.org.